scholarly journals Automated assessment of FDG-PET for differential diagnosis in patients with neurodegenerative disorders

2018 ◽  
Vol 45 (9) ◽  
pp. 1557-1566 ◽  
Author(s):  
Flavio Nobili ◽  
◽  
Cristina Festari ◽  
Daniele Altomare ◽  
Federica Agosta ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Neurodegenerative Disorders ◽  
Fdg Pet ◽  
Automated Assessment

scholarly journals Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Minyoung Oh ◽  
Narae Lee ◽  
Chanwoo Kim ◽  
Hye Joo Son ◽  
Changhwan Sung ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Diagnosis ◽  
Fdg Pet ◽  
Brain Activity ◽  
Visual Assessment ◽  
Dual Phase ◽  
Regional Brain ◽  
Parkinsonian Disorders ◽  
Regional Brain Activity ◽  
Delayed Phase

AbstractDelayed phase 18F-FP-CIT PET (dCIT) can assess the striatal dopamine transporter binding to detect degenerative parkinsonism (DP). Early phase 18F-FP-CIT (eCIT) can assess the regional brain activity for differential diagnosis among parkinsonism similar with 18F-FDG PET. We evaluated the diagnostic performance of dual phase 18F-FP-CIT PET (dual CIT) and 18F-FDG PET compared with clinical diagnosis in 141 subjects [36 with idiopathic Parkinson’s disease (IPD), 77 with multiple system atrophy (MSA), 18 with progressive supranuclear palsy (PSP), and 10 with non-DP)]. Visual assessment of eCIT, dCIT, dual CIT, 18F-FDG and 18F-FDG PET with dCIT was in agreement with the clinical diagnosis in 61.7%, 69.5%, 95.7%, 81.6%, and 97.2% of cases, respectively. ECIT showed about 90% concordance with non-DP and MSA, and 8.3% and 27.8% with IPD and PSP, respectively. DCIT showed ≥ 88% concordance with non-DP, IPD, and PSP, and 49.4% concordance with MSA. Dual CIT showed ≥ 90% concordance in all groups. 18F-FDG PET showed ≥ 90% concordance with non-DP, MSA, and PSP, but only 33.3% concordance with IPD. The combination of 18F-FDG and dCIT yielded ≥ 90% concordance in all groups. Dual CIT may represent a powerful alternative to the combination of 18F-FDG PET and dCIT for differential diagnosis of parkinsonian disorders.

scholarly journals Differential Diagnosis of Neurodegenerative Dementias Using Metabolic Phenotypes on F-18 FDG PET/CT

2014 ◽  
Vol 27 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Madhavi Tripathi ◽  
Manjari Tripathi ◽  
Nishikant Damle ◽  
Suman Kushwaha ◽  
Abhinav Jaimini ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fdg Pet ◽  
Metabolic Phenotypes ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Neurodegenerative Dementias

scholarly journals Pulmonary aspergilloma: A rare differential diagnosis to lung cancer after positive FDG PET scan

2014 ◽  
Vol 12 ◽  
pp. 1-3
Author(s):  
Franziska Spycher ◽  
Gregor J. Kocher ◽  
Mathias Gugger ◽  
Thomas Geiser ◽  
Sebastian R. Ott
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Fdg Pet ◽  
Pet Scan ◽  
Rare Differential Diagnosis ◽  
Fdg Pet Scan ◽  
Pulmonary Aspergilloma

Is 18F-FDG PET/CT capable of differential diagnosis from tuberculous pleurisy from malignant mesothelioma?

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Özlem Özmen ◽  
Ebru Tatci ◽  
Ş. Mustafa Demiröz ◽  
Zuhal Tazeler ◽  
Funda Demirağ
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Fdg Pet ◽  
Pet Ct ◽  
Tuberculous Pleurisy ◽  
18F Fdg ◽  
Fdg Pet Ct

FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses

2003 ◽  
Vol 32 (3) ◽  
pp. 133-138 ◽  
Author(s):  
J. Aoki ◽  
H. Watanabe ◽  
T. Shinozaki ◽  
K. Takagishi ◽  
M. Tokunaga ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Fdg Pet ◽  
Soft Tissue Masses ◽  
Malignant Soft Tissue

scholarly journals Differential diagnosis of parkinsonism: a head-to-head comparison of FDG PET and MIBG scintigraphy

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Joachim Brumberg ◽  
Nils Schröter ◽  
Ganna Blazhenets ◽  
Lars Frings ◽  
Jens Volkmann ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fdg Pet ◽  
Statistical Significance ◽  
Lewy Bodies ◽  
Area Under The Curve ◽  
Mibg Scintigraphy ◽  
Imaging Results ◽  
Case Vignettes ◽  
Heart To Mediastinum Ratio

Abstract[18F]fluorodeoxyglucose (FDG) PET and [123I]metaiodobenzylguanidine (MIBG) scintigraphy may contribute to the differential diagnosis of neurodegenerative parkinsonism. To identify the superior method, we retrospectively evaluated 54 patients with suspected neurodegenerative parkinsonism, who were referred for FDG PET and MIBG scintigraphy. Two investigators visually assessed FDG PET scans using an ordinal 6-step score for disease-specific patterns of Lewy body diseases (LBD) or atypical parkinsonism (APS) and assigned the latter to the subgroups multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal syndrome. Regions-of-interest analysis on anterior planar MIBG images served to calculate the heart-to-mediastinum ratio. Movement disorder specialists blinded to imaging results established clinical follow-up diagnosis by means of guideline-derived case vignettes. Clinical follow-up (1.7 ± 2.3 years) revealed the following diagnoses: n = 19 LBD (n = 17 Parkinson’s disease [PD], n = 1 PD dementia, and n = 1 dementia with Lewy bodies), n = 31 APS (n = 28 MSA, n = 3 PSP), n = 3 non-neurodegenerative parkinsonism; n = 1 patient could not be diagnosed and was excluded. Receiver operating characteristic analyses for discriminating LBD vs. non-LBD revealed a larger area under the curve for FDG PET than for MIBG scintigraphy at statistical trend level for consensus rating (0.82 vs. 0.69, p = 0.06; significant for investigator #1: 0.83 vs. 0.69, p = 0.04). The analysis of PD vs. MSA showed a similar difference (0.82 vs. 0.69, p = 0.11; rater #1: 0.83 vs. 0.69, p = 0.07). Albeit the notable differences in diagnostic performance did not attain statistical significance, the authors consider this finding clinically relevant and suggest that FDG PET, which also allows for subgrouping of APS, should be preferred.

Sign in / Sign up

Export Citation Format

Share Document