scholarly journals Differential Diagnosis of Neurodegenerative Dementias Using Metabolic Phenotypes on F-18 FDG PET/CT

2014 ◽  
Vol 27 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Madhavi Tripathi ◽  
Manjari Tripathi ◽  
Nishikant Damle ◽  
Suman Kushwaha ◽  
Abhinav Jaimini ◽  
...  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Özlem Özmen ◽  
Ebru Tatci ◽  
Ş. Mustafa Demiröz ◽  
Zuhal Tazeler ◽  
Funda Demirağ

2015 ◽  
Vol 40 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Jeong Won Lee ◽  
Jae-Hoon Lee ◽  
Arthur Cho ◽  
Mijin Yun ◽  
Jong Doo Lee ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Guanyun Wang ◽  
Haodan Dang ◽  
Peng Yu ◽  
Honghong Liu ◽  
Yue Wu ◽  
...  

Purpose. To evaluate multiparametric analysis in differential diagnosis between pancreatic serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) as well as the differentiation of the benign and malignant MCNs with 18F-FDG (18-fluorodeoxyglucose) PET/CT (positron emission tomography). Methods. Forty patients with total of 41 lesions (SCNs: 27/41; MCNs: 14/41), who were preoperatively examined with 18F-FDG PET/CT, were retrospectively analyzed. Multiple quantitative parameters using conventional and texture features were included. The combined model was established with complementary PET/MR parameters. The differential diagnostic efficacy of each independent parameter and the combined model were evaluated with receiver operating characteristic (ROC) analysis. Integrated discriminatory improvement (IDI) and net reclassification improvement (NRI) were used to evaluate improvement of diagnostic efficacy by using combination of multiple parameters. Results. Among all independent parameters, the percentile 5th (0.88 ± 0.38 vs 0.47 ± 0.23, P < 0.001 ) showed the highest discriminative diagnostic value. The combination of multiple parameters can improve the differential diagnostic efficacy of SCNs and MCNs (sensitivity = 71.4%, specificity = 77.8%, and AUC = 0.788), and the addition of texture parameters to the conventional parameters allowed a significant reclassification with IDI = 0.236 (95% CI: 0.095–0.377) and categorical NRI = 0.434 (95% CI: 0.030–0.838). SURmax (tumor to normal pancreas ratio, T/P) and SURmax (tumor to aorta ratio, T/A) both showed the highest discriminative diagnostic value (sensitivity = 100.0%, specificity = 70.0%, AUC = 0.900, and Youden index = 0.700) in the differential diagnosis of benign and malignant MCNs, with the cutoff values of 0.84 and 0.90, respectively. Conclusion.Combination of multiple parameters using 18F-FDG PET/CT could further improve differentiation between pancreatic SCNs and MCNs. SURmax (T/P) and SURmax (T/A) could improve differential diagnosis of benign and malignant MCNs.


2013 ◽  
Vol 86 (1028) ◽  
pp. 20130190 ◽  
Author(s):  
J Y Kim ◽  
S H Kim ◽  
H J Lee ◽  
M J Kim ◽  
Y H Kim ◽  
...  

2015 ◽  
Vol 45 ◽  
pp. 1149-1158
Author(s):  
Esra ARSLAN ◽  
Özgül EKMEKÇİOĞLU ◽  
Fatma Arzu GÖRTAN ◽  
Zeynep Funda ENGİN AKCAN ◽  
Melih Engin ERKAN ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
pp. 75-82
Author(s):  
Pavel B. Gelezhe ◽  
Dmitriy V. Bulanov

This paper presents two clinical cases of eosinophilic granuloma of bone diagnosed by CT, MRI, and 18F-FDG PET/CT. In both cases the patients were admitted to the clinic with suspected primary malignant bone tumor and the diagnosis of a solitary eosinophilic granuloma was made based on the results of comprehensive radiological diagnostic examination and histological verification. Solitary eosinophilic granuloma of bone is an infrequent condition, occurring in less than 1% of cases of skeletal tumor masses. The most common eosinophilic granuloma is found in the parietal and frontal bones of the skull and is an osteolytic volumetric mass that gradually increases in size. Although most bone tumors can be detected by radiography, computed tomography is preferred, primarily because of its superior ability to detect cortical bone destruction. The diagnostic accuracy of computed tomography and magnetic resonance imaging may be different. The combined use of radiological and radionuclide methods allows us to narrow the spectrum of differential diagnosis. Unfortunately, relatively low specificity of existing radiological diagnostic studies in most cases does not allow to establish a precise diagnosis, and biopsy with subsequent pathological examination remains the method of choice. These clinical observations demonstrate the need to include eosinophilic granuloma in the differential diagnosis when a solitary osteolytic focus is detected.


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