Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging

1999 ◽  
Vol 26 (11) ◽  
pp. 1465-1574 ◽  
Author(s):  
Gerold Porenta ◽  
Simon Cherry ◽  
Johannes Czernin ◽  
Richard Brunken ◽  
William Kuhle ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Myocardial Blood Flow ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Normal Humans

Effect of alpha 1-adrenoceptor blockade on resting and hyperemic myocardial blood flow in normal humans

1996 ◽  
Vol 271 (4) ◽  
pp. H1302-H1306 ◽  
Author(s):  
R. Lorenzoni ◽  
S. D. Rosen ◽  
P. G. Camici
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Coronary Resistance ◽  
Coronary Vasoconstriction ◽  
Normal Volunteers ◽  
Positron Emission ◽  
Normal Humans

In the present study we aimed to assess the effect of alpha 1-adrenoceptor blockade on resting and hyperemic myocardial blood flow in normal humans. Myocardial blood flow, at baseline and after dipyridamole, was measured with positron emission tomography and 15O-labeled water in 11 normal volunteers at control and during alpha 1-blockade with doxazosin. Baseline myocardial blood flow during alpha 1-blockade was not different from control, whereas coronary resistance was significantly lower (73.48 +/- 18.31 vs. 89.84 +/- 27.96 mmHg.min.ml-1.g-1; P < 0.05). After dipyridamole, myocardial blood flow during alpha 1-blockade was significantly higher (3.50 +/- 0.75 vs. 2.58 +/- 0.54 ml.min-1.g-1; P < 0.01) and coronary resistance lower (25.30 +/- 7.37 vs. 33.89 +/- 7.04 mmHg.min.ml-1.g-1; P < 0.01) compared with control. In conclusion, in normal humans, dipyridamole-induced increase in myocardial blood flow is limited by alpha 1-mediated coronary vasoconstriction.

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