Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival?

2005 ◽  
Vol 55 (8) ◽  
pp. 891-899 ◽  
Author(s):  
N. Ramnath ◽  
D. Tan ◽  
Q. Li ◽  
B. L. Hylander ◽  
P. Bogner ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Mhc Class I ◽  
Cell Lung Cancer ◽  
Antigen Expression ◽  
Small Cell ◽  
Class I ◽  
Prolonged Survival ◽  
Small Cell Lung ◽  
Mhc Class I Antigen

scholarly journals Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer.

1985 ◽  
Vol 161 (5) ◽  
pp. 1135-1151 ◽  
Author(s):  
A Doyle ◽  
W J Martin ◽  
K Funa ◽  
A Gazdar ◽  
D Carney ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Antigen Expression ◽  
Small Cell ◽  
Class I ◽  
Small Cell Lung ◽  
Histocompatibility Antigens ◽  
Beta 2 Microglobulin ◽  
Almost All

We have found markedly deficient expression of the class I major histocompatibility antigens HLA-A,B,C and beta 2m on human small-cell lung cancer (SCLC) lines and fresh tumor samples. The deficit of HLA-A,B,C and beta 2-microglobulin (beta 2m) antigen expression was demonstrated with both radiobinding assays and indirect immunofluorescence assays. Immunoprecipitation of metabolically labeled cells with antibodies to class I antigens showed most SCLC lines to have synthesized almost no beta 2m and HLA-A,B,C proteins. Northern blot analysis, using human HLA-A,B, and beta 2m cDNA probes, showed that almost all SCLC lines tested had markedly decreased amounts of HLA and beta 2m mRNA, but both gene products could be induced with interferon treatment of SCLC lines. We conclude that human SCLC, in contrast to other lung cancer types, is characterized by greatly reduced transcription of HLA-A,B,C and beta 2m genes, which suggests the existence of a mechanism for evading the host immune response to the tumor and of an E1a-like product in this type of tumor cell.

Lewis Y antigen expression and postoperative survival in non–small cell lung cancer

1998 ◽  
Vol 66 (5) ◽  
pp. 1745-1750 ◽  
Author(s):  
Fumihiro Tanaka ◽  
Ryo Miyahara ◽  
Yohsuke Ohtake ◽  
Kazuhiro Yanagihara ◽  
Tatsuo Fukuse ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Antigen Expression ◽  
Small Cell ◽  
Postoperative Survival ◽  
Small Cell Lung ◽  
Lewis Y Antigen ◽  
Lewis Y

scholarly journals Prolonged Survival of Patients With Non–Small-Cell Lung Cancer With Leptomeningeal Carcinomatosis in the Modern Treatment Era

2014 ◽  
Vol 15 (3) ◽  
pp. 202-206 ◽  
Author(s):  
Jonathan W. Riess ◽  
Seema Nagpal ◽  
Michael Iv ◽  
Michael Zeineh ◽  
Matthew A. Gubens ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Leptomeningeal Carcinomatosis ◽  
Small Cell ◽  
Prolonged Survival ◽  
Small Cell Lung ◽  
Modern Treatment

Prognostic Influence of Loss of Blood Group A Antigen Expression in Pathologic Stage I Non-Small-Cell Lung Cancer

2012 ◽  
Vol 48 (2) ◽  
pp. 49-54 ◽  
Author(s):  
Pablo León-Atance ◽  
Nicolás Moreno-Mata ◽  
Federico González-Aragoneses ◽  
Miguel Ángel Cañizares-Carretero ◽  
Enrique Poblet-Martínez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Blood Group ◽  
Cell Lung Cancer ◽  
Antigen Expression ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Blood Group A ◽  
Group A
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