scholarly journals Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer

2011 ◽  
Vol 60 (11) ◽  
pp. 1639-1645 ◽  
Author(s):  
Riccardo Turrini ◽  
Anna Merlo ◽  
Riccardo Dolcetti ◽  
Paola Zanovello ◽  
Antonio Rosato
2005 ◽  
Vol 66 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Giulio Lelio Palmisano ◽  
Elisabetta Contardi ◽  
Anna Morabito ◽  
Vittoria Gargaglione ◽  
Giovanni Battista Ferrara ◽  
...  

1996 ◽  
Vol 50 (3) ◽  
pp. 149-154 ◽  
Author(s):  
Dharam P. Singal ◽  
Ming Ye ◽  
Jin Ni ◽  
Denis P. Snider

1991 ◽  
Vol 47 (S6) ◽  
pp. 123-130 ◽  
Author(s):  
Francisco Ruiz-Cabello ◽  
Millán Perez-Ayala ◽  
Ovidio Gomez ◽  
Maximino Redondo ◽  
Angel Concha ◽  
...  

2012 ◽  
Vol 188 (5) ◽  
pp. 431-437 ◽  
Author(s):  
A. Yaromina ◽  
S. Meyer ◽  
C. Fabian ◽  
K. Zaleska ◽  
U.G.A. Sattler ◽  
...  

1996 ◽  
Vol 106 (5) ◽  
pp. 1114-1118 ◽  
Author(s):  
Slawomir Majewski ◽  
Maria Marczak ◽  
Andrzej Szmurlo ◽  
Stefania Jablonska ◽  
Werner Bollag

1997 ◽  
Vol 60 (2) ◽  
pp. 210-215 ◽  
Author(s):  
E. Izbicka ◽  
C. R. Dunstan ◽  
D. Horn ◽  
M. Harris ◽  
S. Harris ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ricardo C. Calhelha ◽  
Soraia Falcão ◽  
Maria João R. P. Queiroz ◽  
Miguel Vilas-Boas ◽  
Isabel C. F. R. Ferreira

With a complex chemical composition rich in phenolic compounds, propolis (resinous substance collected byApis melliferafrom various tree buds) exhibits a broad spectrum of biological activities. Recently,in vitroandin vivodata suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7—breast adenocarcinoma, NCI-H460—non-small cell lung carcinoma, HCT15—colon carcinoma, HeLa—cervical carcinoma, and HepG2—hepatocellular carcinoma), and non-tumor primary cells (PLP2). The studied propolis presented high cytotoxic potential for human tumor cell lines, mostly for HCT15. Nevertheless, excluding HCT15 cell line, the extracts at the GI50obtained for tumor cell lines showed, in general, cytotoxicity for normal cells (PLP2). Propolis phenolic extracts comprise phytochemicals that should be further studied for their bioactive properties against human colon carcinoma. In the other cases, the proximity of thein vitrocytotoxic doses for tumor and normal cell lines should be confirmed byin vivotests and may highlight the need for selection of specific compounds within the propolis extract.


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