scholarly journals Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer

2018 ◽  
Vol 68 (1) ◽  
pp. 109-120 ◽  
Author(s):  
Aliyah M. Weinstein ◽  
Nicolas A. Giraldo ◽  
Florent Petitprez ◽  
Catherine Julie ◽  
Laetitia Lacroix ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Colorectal Cancer ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

The maturation stage of tumoral tertiary lymphoid structures to predict recurrence risk in localized colorectal cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15083-e15083
Author(s):  
Florian Posch ◽  
Karina Silina ◽  
Ulf Petrausch ◽  
Sebastian Leibl ◽  
Axel Muendlein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Structural Equation ◽  
Critical Role ◽  
Multivariable Analysis ◽  
Recurrence Risk ◽  
Maturation Stage ◽  
Maturation Stages ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

e15083 Background: The tumor immune infiltrate and organized lymphocytic aggregates within the tumor microenvironment, known as tertiary lymphoid structures (TLS), play a critical role in cancer. We hypothesize that the maturation stage of TLS harbors prognostic information on recurrence risk in patients (pts) with non-metastatic colorectal cancer (nmCRC). Methods: In a comprehensive immunofluorescence and clinical analysis of 111 pts with UICC stage II & III nmCRC (median age: 65 yrs; female: n = 53 (48%); stage III: n = 69 (62%)), we quantified the number and maturation status of tumor-associated TLS in baseline surgical specimens:[1] Early TLS (E-TLS, composed of dense lymphocytic aggregates without follicular dendritic cells (FDCs), [2] Primary follicle-like TLS (PFL-TLS, having FDCs but no germinal center (GC) reaction), and [3] Secondary follicle-like TLS (SFL-TLS, having an active GC reaction). The 3-year incidence of recurrence was the primary endpoint of this study, which occurred in 19 pts (3-year recurrence risk = 18.3%). Results: Most TLS formed in tissue adjacent to the tumor. The median number of TLS/mm of tumor perimeter was 1.0 [25th-75th percentile: 0.5-1.7]. The average proportions of different TLS maturation stages were 56% of E-TLS [40-78], 20% of PFL-TLS [6-37], and 16% of SFL-TLS [0-32]. A structural equation model was fitted to summarize the TLS counts and maturation stages into a TLS maturation immunoscore for predicting recurrence. 3-year recurrence risks were 31.7% (95%CI: 17.2-47.3), 15.9% (5.7-30.5), and 9.4% (2.4-22.4) in pts in the 1st, 2nd, and 3rd tertile of the score (Gray’s test p = 0.05). A higher score was significantly associated with a lower recurrence risk (Hazard ratio (HR) for 10 units increase = 0.76, 95%CI: 0.59-0.97, p = 0.03), and this association prevailed in multivariable analysis adjusting for age, ECOG performance status, stage, and adjuvant chemotherapy (Adjusted HR = 0.73, 0.54-0.99, p = 0.05). Conclusions: Tumors of nmCRC pts with a very low risk of recurrence are characterized by an increased fraction of mature TLS comprising FDCs and GCs. If confirmed prospectively, adjuvant chemotherapy may be avoided in nmCRC pts with a high TLS maturation score.

PS3-05 The chemokine network in the formation of tertiary lymphoid structures in colorectal cancer

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 83
Author(s):  
F. Marchesi ◽  
A.P. Martin ◽  
G.C. Furtado ◽  
P. Allavena ◽  
S.A. Lira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

scholarly journals Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

2020 ◽  
Vol 8 (6) ◽  
pp. 724-731 ◽  
Author(s):  
Atsuyo Ikeda ◽  
Takayuki Ogino ◽  
Hisako Kayama ◽  
Daisuke Okuzaki ◽  
Junichi Nishimura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Tertiary Lymphoid Structures ◽  
Group 3 ◽  
Lymphoid Structures

Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Immunity ◽  
2021 ◽  
Author(s):  
Abigail E. Overacre-Delgoffe ◽  
Hannah J. Bumgarner ◽  
Anthony R. Cillo ◽  
Ansen H.P. Burr ◽  
Justin T. Tometich ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Immunity ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

scholarly journals Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

2021 ◽  
Author(s):  
Abigail E. Overacre-Delgoffe ◽  
Anthony R. Cillo ◽  
Hannah J. Bumgarner ◽  
Ansen H.P. Burr ◽  
Justin T. Tometich ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Tumor Immunity ◽  
T Cell Response ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures ◽  
And Control

SummaryColorectal cancer (CRC) is a common and deadly disease, and patients with metastatic tumors often fail to respond to therapy. While select members of the microbiome are associated with improved anti-tumor immunity, mechanistic understanding of how the microbiome provides a benefit is lacking. We show that modification of the CRC-associated microbiome with a single immunogenic commensal bacteria can alter T cell differentiation, inhibit tumor growth, and increase survival. Microbiome-driven control of CRC required the formation of colonic tertiary lymphoid structures (TLS) and increased infiltration of the tumor with cytotoxic immune cells. In the context of CRC, CD4+ T cells specific to the newly introduced commensals differentiated into T follicular helper cells and were necessary for the formation of TLS, immune infiltration of the tumor, and control over CRC. Thus, modification of the intestinal T cell response by the microbiome can be used to augment anti-tumor immunity in colorectal cancer.

scholarly journals Tumor-infiltrating lymphocyte subsets and tertiary lymphoid structures in pulmonary metastases from colorectal cancer

2016 ◽  
Vol 33 (7) ◽  
pp. 727-739 ◽  
Author(s):  
Thomas Schweiger ◽  
Anna Sophie Berghoff ◽  
Christoph Glogner ◽  
Olaf Glueck ◽  
Orsolya Rajky ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymphocyte Subsets ◽  
Pulmonary Metastases ◽  
Tumor Infiltrating Lymphocyte ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

scholarly journals Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer

2020 ◽  
Vol 9 (1) ◽  
pp. 1724763 ◽  
Author(s):  
Kyoko Yamaguchi ◽  
Mamoru Ito ◽  
Hirofumi Ohmura ◽  
Fumiyasu Hanamura ◽  
Michitaka Nakano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Advanced Colorectal Cancer ◽  
Disease Relapse ◽  
Helper T Cell ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures

scholarly journals Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

2017 ◽  
Vol 7 (2) ◽  
pp. e1378844 ◽  
Author(s):  
Florian Posch ◽  
Karina Silina ◽  
Sebastian Leibl ◽  
Axel Mündlein ◽  
Holger Moch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stage Ii ◽  
Tertiary Lymphoid Structures ◽  
Lymphoid Structures
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