Utilizing Muscle-Derived Stem Cells to Enhance Long-Term Retention and Aesthetic Outcome of Autologous Fat Grafting: Pilot Study in Mice

2011 ◽  
Vol 36 (1) ◽  
pp. 186-192 ◽  
Author(s):  
Zhiqiang Ma ◽  
Duanyang Han ◽  
Peipei Zhang ◽  
Jenny F. Yang ◽  
Yiqiang Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pilot Study ◽  
Fat Grafting ◽  
Aesthetic Outcome ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Term Retention ◽  
Long Term Retention

Muscle derived stem cell contains the potential to enhance long term retention as well as an aesthetic outcome of autologous fat grafting

2011 ◽  
Vol 76 (6) ◽  
pp. 805-808 ◽  
Author(s):  
Duanyang Han ◽  
Zhiqiang Ma ◽  
Peipei Zhang ◽  
Jenny F. Yang ◽  
Yingbo Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Fat Grafting ◽  
Aesthetic Outcome ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Term Retention ◽  
Long Term Retention

scholarly journals Treatment of “En Coupe De Sabre “ Linear Scleroderma. Soft Tissue Augmentation and Regeneration by Autologous Fat Transfer

2021 ◽  
pp. 30
Author(s):  
◽  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Fat Grafting ◽  
Soft Tissue Augmentation ◽  
Congenital Deformity ◽  
Autologous Fat Grafting ◽  
Fat Transfer ◽  
Autologous Fat ◽  
Autologous Fat Transfer ◽  
Linear Scleroderma

Aim: Frontal linear scleroderma, also known as ‘‘en coup de sabre,’’ is a congenital deformity characterized by atrophy and furrowing of the skin of the front parietal area above the level of the eyebrows. In most cases it occurs as a single paramedian line that may be associated with hypoplasia of underlying structures and facial hemiatrophy. In case of a wide lesion many reconstructive strategies have been proposed. The modern approach is aimed at augmentation of the tissue deficiency by using lipostructure and tissue regeneration. Autologous fat transfer (AFT) seems to be an effective strategy to restore the normal volume and contour of the face while providing a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. Methods: In this report, we present a rare case of linear scleroderma en coupe de sabre which was successfully managed with three stages of autologous fat grafting. Conclusion: The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need to cooperate in informing clinicians about what practices are based on evidence and to encourage support of additional research. There is increasing interest in a possible therapeutic effect of ADSCs from processed lipoaspirate for a wide spectrum of clinical applications in the facial and craniofacial area. AFT can be used in any facial area where soft tissue is lacking or where there is scarring, producing natural and long-lasting results. Mesenchymal stem cells represent a great tool in regenerative medicine. However, more definitive studies are needed to answer specific questions regarding the best technique to be used and the role of ADSCs. Autologous fat grafting provides a safe and easy approach for the treatment of linear scleroderma en coup de sabre, long-term clinically satisfactory results can be obtained.

Allogeneic Adipose-Derived Stem Cells Protect Fat Grafts at the Early Stage and Improve Long-Term Retention in Immunocompetent Rats

2015 ◽  
Vol 39 (4) ◽  
pp. 625-634 ◽  
Author(s):  
Jun Zhang ◽  
Yunchuan Wang ◽  
Bin Zhao ◽  
Lei Fan ◽  
Xiaozhi Bai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Early Stage ◽  
Adipose Derived Stem Cells ◽  
Fat Grafts ◽  
Term Retention ◽  
Long Term Retention

Autologous Fat Grafting for Oncologic Patients: A Literature Review

2021 ◽  
Vol 41 (Supplement_1) ◽  
pp. S61-S68
Author(s):  
Allison J Seitz ◽  
Malke Asaad ◽  
Summer E Hanson ◽  
Charles E Butler ◽  
Rene D Largo
Keyword(s):  
Stem Cells ◽  
Animal Models ◽  
Cancer Patients ◽  
Tissue Regeneration ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Reconstructive Procedures ◽  
Autologous Fat ◽  
Increased Risk ◽  
Oncologic Patients

Abstract Autologous fat grafting (AFG) serves as an effective method to address volume defects, contour irregularities, and asymmetry in both aesthetic and reconstructive procedures. In recent years, there has been growing concern about the potential of cancer recurrence and interference with cancer surveillance in oncologic patients receiving AFG. The adipose tissue contains adipose-derived stem cells (ASCs), a specific type of mesenchymal stem cells, that facilitate secretion of numerous growth factors which in turn stimulate tissue regeneration and angiogenesis. As such, it has been theorized that ASCs may also have the potential to stimulate cancer cell proliferation and growth when used in oncologic patients. Multiple research studies have demonstrated the ability of ACSs to facilitate tumor proliferation in animal models. However, clinical research in oncologic patients has yielded contradictory findings. Although the literature pertaining to oncologic safety in head and neck, as well as sarcoma, cancer patients remains limited, studies demonstrate no increased risk of tumor recurrence in these patient populations receiving AFG. Similarly, both the efficacy and safety of AFG have been well established in breast cancer patients through numerous clinical studies. More recently, preclinical research in animal models has shown that AFG has the potential to facilitate tissue regeneration and improve joint contracture following irradiation. Ultimately, further research is needed to elucidate the safety of AFG in a variety of oncologic patients, as well as explore its use in tissue regeneration, particularly in the setting of radiotherapy. Level of Evidence: 4

scholarly journals A Prospective Pilot Study Comparing Rate of Processing Techniques in Autologous Fat Grafting

2018 ◽  
Vol 39 (3) ◽  
pp. 331-337 ◽  
Author(s):  
Summer E Hanson ◽  
Patrick B Garvey ◽  
Edward I Chang ◽  
Gregory Reece ◽  
Jun Liu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Prospective Pilot Study ◽  
Processing Techniques
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