Autologous Fat Transfer
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Burns ◽  
2021 ◽  
Ahmed M. Abouzaid ◽  
Mohamed E. El Mokadem ◽  
Ahmed K. Aboubakr ◽  
Mohamed A. Kassem ◽  
Ahmed K. Al Shora ◽  

2021 ◽  
Vol 506 (1-2) ◽  
Vu Ngoc Lam ◽  
Le Thi Thu Hai ◽  
Nguyen Phuong Tien

Autologous fat grafting is a technique that has been used for a long time in the field of plastic surgery. Besides many advantages, the complications, which can range from mild such as hematoma, infection, calcification, necrosis... even death is a big problem.  The article presents a case of using autologous fat taken from the abdomen to graft onto the facial area with complications of severe infection in both the receiving and donor sites, causing necrosis of fat and skin in both areas. The treatment takes a long time with different procedures, but the consequences for the patient are still very serious both in terms of aesthetics and function. The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour.

2021 ◽  
Vol 9 (8) ◽  
pp. e3734
Shigeki Sakai ◽  
Naohiro Ishii ◽  
Yukie Nakamura ◽  
Kyoichi Matsuzaki ◽  
Shigemi Sakai ◽  

Johannes Eschborn ◽  
Philipp Kruppa ◽  
Iakovos Georgiou ◽  
Manfred Infanger ◽  
Mojtaba Ghods

Autologous fat transfer may offer a simple and effective treatment option for chronic wound patients, delivering adipose-derived stem cells, with potent regenerative attributes. Nevertheless, the clinical benefit has not yet been sufficiently demonstrated. A total of 39 wound patients were treated with autologous fat transfer (AFT) and matched with a control group, according to the identified confounding variables “gender” and “method of defect closure.” All data were acquired retrospectively. Primary outcome was “wound closure” and “reduction of wound size.” After a follow-up of 48 weeks, there was no significant difference in primary outcome (wound closure P = .54) between both groups. The relative wound reduction after fat transfer was 69.9% ± 42.7% compared to 53.4% ± 106.8% in the control group ( P = .91). Subgroup analysis of all patients, healed by secondary intention, revealed an increased wound size reduction ( P  = .03) and wound closure rate ( P = .20) in the case group after 12 weeks. No adverse events were recorded. Fat grafting can reduce the wound size if left to secondary healing and may be considered individually for reconstructive purposes. A repeated application of autologous fat might be beneficial due to a temporary effect.

2021 ◽  
Vol Publish Ahead of Print ◽  
Natalie A. Homer ◽  
Anika S. Patel ◽  
Aliza Epstein ◽  
Vikram D. Durairaj ◽  
Tanuj Nakra


Aim: Frontal linear scleroderma, also known as ‘‘en coup de sabre,’’ is a congenital deformity characterized by atrophy and furrowing of the skin of the front parietal area above the level of the eyebrows. In most cases it occurs as a single paramedian line that may be associated with hypoplasia of underlying structures and facial hemiatrophy. In case of a wide lesion many reconstructive strategies have been proposed. The modern approach is aimed at augmentation of the tissue deficiency by using lipostructure and tissue regeneration. Autologous fat transfer (AFT) seems to be an effective strategy to restore the normal volume and contour of the face while providing a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. Methods: In this report, we present a rare case of linear scleroderma en coupe de sabre which was successfully managed with three stages of autologous fat grafting. Conclusion: The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need to cooperate in informing clinicians about what practices are based on evidence and to encourage support of additional research. There is increasing interest in a possible therapeutic effect of ADSCs from processed lipoaspirate for a wide spectrum of clinical applications in the facial and craniofacial area. AFT can be used in any facial area where soft tissue is lacking or where there is scarring, producing natural and long-lasting results. Mesenchymal stem cells represent a great tool in regenerative medicine. However, more definitive studies are needed to answer specific questions regarding the best technique to be used and the role of ADSCs. Autologous fat grafting provides a safe and easy approach for the treatment of linear scleroderma en coup de sabre, long-term clinically satisfactory results can be obtained.


Aim: Autologous fat transfer (AFT) for the correction of maxillofacial defects was first reported at the end of the 19th century. AFT was introduced as a way of improving facial esthetics and in the last few years has expanded into applications in craniomaxillofacial reconstructive surgery and regenerative therapy. This protocol is part of translational medicine. The aim of translational medicine, or translational science, is to combine disciplines, resources, expertise, and techniques based on three main pillars: bench, bedside, and community. The primary goals to coalesce assets of various natures to significantly improve the global healthcare system. AFT is thus part of translational medicine in tissue healing, regeneration and augmentation. Methods: Several techniques have been suggested for harvesting and grafting the fat. The Authors follow Coleman’s technique with centrifugation and infiltration using different types and sizes of cannulas. Conclusion: This review provides a fairly comprehensive summary of the many exciting possibilities that exist in the field of facial fat grafting. Five clinical cases are presented and discussed. Translational medicine is the basis of this new reconstructive and regenerative field of science and research.

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