Treatment of “En Coupe De Sabre “ Linear Scleroderma. Soft Tissue Augmentation and Regeneration by Autologous Fat Transfer

American Journal of Surgical Research and Reviews ◽

10.28933/ajsrr-2021-07-0103 ◽

2021 ◽

pp. 30

Author(s):

◽

Keyword(s):

Stem Cells ◽

Soft Tissue ◽

Fat Grafting ◽

Soft Tissue Augmentation ◽

Congenital Deformity ◽

Autologous Fat Grafting ◽

Fat Transfer ◽

Autologous Fat ◽

Autologous Fat Transfer ◽

Linear Scleroderma

Aim: Frontal linear scleroderma, also known as ‘‘en coup de sabre,’’ is a congenital deformity characterized by atrophy and furrowing of the skin of the front parietal area above the level of the eyebrows. In most cases it occurs as a single paramedian line that may be associated with hypoplasia of underlying structures and facial hemiatrophy. In case of a wide lesion many reconstructive strategies have been proposed. The modern approach is aimed at augmentation of the tissue deficiency by using lipostructure and tissue regeneration. Autologous fat transfer (AFT) seems to be an effective strategy to restore the normal volume and contour of the face while providing a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. Methods: In this report, we present a rare case of linear scleroderma en coupe de sabre which was successfully managed with three stages of autologous fat grafting. Conclusion: The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need to cooperate in informing clinicians about what practices are based on evidence and to encourage support of additional research. There is increasing interest in a possible therapeutic effect of ADSCs from processed lipoaspirate for a wide spectrum of clinical applications in the facial and craniofacial area. AFT can be used in any facial area where soft tissue is lacking or where there is scarring, producing natural and long-lasting results. Mesenchymal stem cells represent a great tool in regenerative medicine. However, more definitive studies are needed to answer specific questions regarding the best technique to be used and the role of ADSCs. Autologous fat grafting provides a safe and easy approach for the treatment of linear scleroderma en coup de sabre, long-term clinically satisfactory results can be obtained.

Download Full-text

Autologous Fat Transfer and Cell-Based Strategies for Soft Tissue Reconstruction

Current Tissue Engineering ◽

10.2174/2211542002999140109150722 ◽

2014 ◽

Vol 3 (1) ◽

pp. 62-69

Author(s):

Kshemendra Senarath-Yapa ◽

Rebecca Garza ◽

Adrian McArdle ◽

Graham Walmsley ◽

Michael Hu ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissue Reconstruction ◽

Fat Transfer ◽

Autologous Fat ◽

Autologous Fat Transfer ◽

Tissue Reconstruction

Download Full-text

Treatment of linear scleroderma “En coup de Sabre” with single‐stage autologous fat grafting: A case report and review of the literature

Journal of Cosmetic Dermatology ◽

10.1111/jocd.13490 ◽

2020 ◽

Vol 20 (1) ◽

pp. 285-289 ◽

Cited By ~ 1

Author(s):

Rita Ayoub ◽

Salim C. Saba

Keyword(s):

Case Report ◽

Fat Grafting ◽

Single Stage ◽

Review Of The Literature ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Linear Scleroderma

Download Full-text

Principles and Applications of Fat Grafting in Plastic Surgery

Seminars in Plastic Surgery ◽

10.1055/s-0039-1693438 ◽

2019 ◽

Vol 33 (03) ◽

pp. 147-154 ◽

Cited By ~ 2

Author(s):

Amjed Abu-Ghname ◽

Aurelia Trisliana Perdanasari ◽

Edward M. Reece

Keyword(s):

Plastic Surgery ◽

Clinical Applications ◽

Fat Grafting ◽

Soft Tissue Augmentation ◽

Fat Transplantation ◽

Basic Principles ◽

Autologous Fat ◽

Autologous Fat Transfer ◽

Autologous Fat Transplantation ◽

Injection Techniques

AbstractAutologous fat transplantation has become increasingly popular in recent years. Its biocompatable properties and availability made it a widely used treatment modality for soft tissue augmentation and volume replacement in both reconstructive and aesthetic plastic surgery. Multiple protocols and clinical applications have been described in the literature, with wide variations in the harvesting, processing, and injection techniques. In this review, the authors will discuss the basic principles and clinical applications of fat grafting in plastic and reconstructive surgery. The article will then conclude with a discussion of fat grafting limitations as well as potential future applications, giving the reader a well-rounded understanding of autologous fat transfer.

Download Full-text

Breast Augmentation by Water-Jet Assisted Autologous Fat Grafting: A Report of 300 Operations

The Surgery Journal ◽

10.1055/s-0036-1584165 ◽

2016 ◽

Vol 02 (02) ◽

pp. e19-e30 ◽

Cited By ~ 5

Author(s):

Daniel Muench

Keyword(s):

Breast Augmentation ◽

Fat Grafting ◽

Water Jet ◽

Fat Cell ◽

Volume Increase ◽

Fat Transfer ◽

Autologous Fat ◽

Autologous Fat Transfer ◽

Fat Deposits ◽

Moderate Volume

Background The BEAULI -method (Breast Augmentation by Lipotransfer) is available for extraction and processing of large transplantable fat quantities. The aim of this work is to describe the surgical technique precisely and reproducibly and to provide an overview of the autologous fat transfer based on surgical experience. Method The author performed 300 autologous fat transplantations on 254 women between September 3, 2010, and May 13, 2015. Patients desiring moderate volume increase, fuller and firmer breasts, as well as an optimization of the silhouette, ideally with the concurrent desire of the correction of unwanted fat deposits, were selected. The fat was extracted via water-jet assisted liposuction (Body-jet, Human Med AG, Schwerin, Germany), and the fat cells were subsequently separated with the Lipocollector® (Human Med AG, Schwerin, Germany). Results The results were assessed with a control exam and photo comparison and were based on the responses on a questionnaire. Overall, 35.9% of the patients defined the result as very good, 38.6% as good, 22.4% as satisfactory, and 3.1% as poor. Conclusion This study shows that the autologous fat cell transplantation into the female breast via water-jet assisted liposuction achieves a moderate and harmoniously appearing breast volume enlargement as well as contour improvement. Further studies with more cases and longer observation periods over several years could contribute to improving the method of the autologous fat transfer regarding the grow-in rate, efficiency, and safety.

Download Full-text

Treatment of Soft Tissue Contour Defects by a Combination of Surgical Subcision with a Beaver Tympanoplasty Blade and Autologous Fat Grafting

Aesthetic Plastic Surgery ◽

10.1007/s00266-009-9442-9 ◽

2009 ◽

Vol 34 (3) ◽

pp. 406-407 ◽

Cited By ~ 5

Author(s):

Y. S. Lau ◽

G. J. Offer

Keyword(s):

Soft Tissue ◽

Fat Grafting ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Contour Defects

Download Full-text

Autologous Fat Grafting for Oncologic Patients: A Literature Review

Aesthetic Surgery Journal ◽

10.1093/asj/sjab126 ◽

2021 ◽

Vol 41 (Supplement_1) ◽

pp. S61-S68

Author(s):

Allison J Seitz ◽

Malke Asaad ◽

Summer E Hanson ◽

Charles E Butler ◽

Rene D Largo

Keyword(s):

Stem Cells ◽

Animal Models ◽

Cancer Patients ◽

Tissue Regeneration ◽

Fat Grafting ◽

Autologous Fat Grafting ◽

Reconstructive Procedures ◽

Autologous Fat ◽

Increased Risk ◽

Oncologic Patients

Abstract Autologous fat grafting (AFG) serves as an effective method to address volume defects, contour irregularities, and asymmetry in both aesthetic and reconstructive procedures. In recent years, there has been growing concern about the potential of cancer recurrence and interference with cancer surveillance in oncologic patients receiving AFG. The adipose tissue contains adipose-derived stem cells (ASCs), a specific type of mesenchymal stem cells, that facilitate secretion of numerous growth factors which in turn stimulate tissue regeneration and angiogenesis. As such, it has been theorized that ASCs may also have the potential to stimulate cancer cell proliferation and growth when used in oncologic patients. Multiple research studies have demonstrated the ability of ACSs to facilitate tumor proliferation in animal models. However, clinical research in oncologic patients has yielded contradictory findings. Although the literature pertaining to oncologic safety in head and neck, as well as sarcoma, cancer patients remains limited, studies demonstrate no increased risk of tumor recurrence in these patient populations receiving AFG. Similarly, both the efficacy and safety of AFG have been well established in breast cancer patients through numerous clinical studies. More recently, preclinical research in animal models has shown that AFG has the potential to facilitate tissue regeneration and improve joint contracture following irradiation. Ultimately, further research is needed to elucidate the safety of AFG in a variety of oncologic patients, as well as explore its use in tissue regeneration, particularly in the setting of radiotherapy. Level of Evidence: 4

Download Full-text

Autologous Fat Grafting in Management of Patients with Progressive Hemifacial Atrophy

Journal of Advanced Plastic Surgery Research ◽

10.31907/2414-2093.2016.02.10 ◽

2016 ◽

Vol 2 (1) ◽

pp. 66-70

Author(s):

Jainath Reddappa ◽

Keyword(s):

Soft Tissue ◽

Face Mask ◽

Fat Grafting ◽

Fat Absorption ◽

Autologous Fat Grafting ◽

Hemifacial Atrophy ◽

Autologous Fat ◽

Progressive Hemifacial Atrophy ◽

Grade 3 ◽

Approximate Amount

Background: Progressive hemi facial atrophy or Romberg disease is a rare neurocutaneous syndrome characterized by slow progressive atrophy on one side of face involving skin, subcutaneous and connective tissue. Various methods have been described for soft tissue augmentation in patients with progressive hemi facial atrophy. Autologous fat, dermofat, fascial grafts have been used for grade 1,2 and 3 atrophy. Free flaps, cartilage and bone grafts are described for grade 3 and 4 atrophy. Aims and objectives: To study efficacy of autologous fat graft in patients with grade 1, 2 and 3 hemi facial atrophy. Strategies to reduce fat absorption and to calculate approximate amount of fat required required by facial mask template. Observations: It is a prospective study conducted in Department of plastic surgery, Bangalore Medical college and Research Institute, Bangalore in 10 patients with grade 2 and 3 Progressive hemi facial atrophy. All patients with stable non-progressive atrophy were graded for severity of disease and face-mask templates were prepared by pro-sthodontists to know approximate amount of fat required for injection. Fat was aspirated by low-pressure small suction cannulas manually and infiltrated at multiple points and in multiple planes after sedimentation and separation of fat. Five of the patients with grade 2 and 3 of patients with grade 3 atrophy were satisfied with symmetric face and with emotional betterment. Two patients needed repeat fat grafting after 2 years of follow-up. Conclusion: Autologous fat grafting is a simple and safe method for augmentation of soft tissue in patients with grade 1, 2 and 3 Progressive hemi facial atrophy. Aspiration of fat with low-pressure small cannulas and infiltrating in multiple planes improves fat survival. Preparing face-mask templates gives an idea of approximate volume of fat required. Keywords: Progressive hemifacial atrophy, Autologous fat grafting, Face-mask templates, Strategies for decreased fat absorption.

Download Full-text

Autologous Fat Grafting in the Treatment of Facial Scleroderma

Dermatology Research and Practice ◽

10.1155/2018/6568016 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Mehdi Gheisari ◽

Arman Ahmadzadeh ◽

Nilofar Nobari ◽

Behzad Iranmanesh ◽

Nikoo Mozafari

Keyword(s):

Systemic Sclerosis ◽

Treatment Options ◽

Mouth Opening ◽

Fat Grafting ◽

Systemic Autoimmune Disease ◽

P Value ◽

Fat Injection ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Autologous Fat Transfer

Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT), volumizing and aesthetic effects based on pre- and posttreatment photographs, possible side effects, and global patient satisfaction. Clinical assessment showed autologous fat transfer significantly improved mouth opening capacity and the MHISS and Rodnan score of patients with facial scleroderma (p value <.001). The aesthetic and/or functional results of fat injection were satisfying to about 80% of the patients. The changes in CRRT values were not significant. Our findings support the possible therapeutic role of autologous fat grafting in improving facial scleroderma both in aesthetic and in functional aspects. This trial is registered with IRCT20180209038677N1.

Download Full-text