Vasa vasorum of the human great saphenous vein

2002 ◽  
Vol 24 (6) ◽  
pp. 376-380 ◽  
Author(s):  
D. Kachlík ◽  
A. Lametschwandtner ◽  
J. Rejmontová ◽  
J. Stingl ◽  
I. Vaněk
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Vasa Vasorum

Fibrinolytic Activity of Human Veins in Arms and Legs

1968 ◽  
Vol 20 (01/02) ◽  
pp. 247-256 ◽  
Author(s):  
M Pandolfi ◽  
B Robertson ◽  
S Isacson ◽  
Inga Marie Nilsson
Keyword(s):  
Saphenous Vein ◽  
Fibrinolytic Activity ◽  
Great Saphenous Vein ◽  
Normal Subjects ◽  
Vasa Vasorum ◽  
Tissue Sections ◽  
Below The Knee ◽  
The Media

SummaryA modification of the fibrin slide method of Todd permitting a semiquantitative estimation of the fibrinolytic activity in tissue sections is described. By means of this technique, the authors have studied the fibrinolytic activity of the great saphenous vein and of superficial veins of the arm and leg in patients suffering from varices and in normal subjects. It was found that:1. Fibrinolytic activity is localized, in these vessels, mainly to the vasa vasorum of the adventitia. The media is moderately active. Intimal cells are active only when detached.2. The great saphenous vein is more active above than below the knee.3. The veins of the arm are definitely more active than the veins of the leg.4. The activator of plasminogen demonstrated in the sections by the fibrin slide method is a fairly stable enzyme still active after exposure to 60° C and resistent to moderate variations of pH.

scholarly journals Exploring the Microangioarchitecture of the Vasa Vasorum of the Human Great Saphenous Vein by SEM and 3D Morphometry of Vascular Corrosion Casts

2013 ◽  
Vol 19 (S2) ◽  
pp. 244-245
Author(s):  
K.M. Erlbacher ◽  
M. Herbst ◽  
B. Minnich
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Vasa Vasorum ◽  
Corrosion Casts ◽  
Vascular Corrosion Casts

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

Morphological features of vasa vasorum in pathologically changed human great saphenous vein and its tributaries

VASA ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 127-136 ◽  
Author(s):  
Kachlík ◽  
Stingl ◽  
Sosna ◽  
Straka ◽  
Lametschwandtner ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Bypass Surgery ◽  
Great Saphenous Vein ◽  
Coronary Bypass ◽  
Vasa Vasorum ◽  
Nutritional Conditions ◽  
India Ink ◽  
Metabolic Conditions ◽  
Medial Hyperplasia ◽  
Venous Wall

Background: The question whether the primary increase of vasa vasorum (VV) of venous wall (i) plays an initial role in varicogenesis or (ii) is an expression of impairment of the nutritional conditions in superficial veins of lower extremities is not unambiguously solved yet. The aim of the study was to describe the arrangement of the VV within the wall of the human great saphenous vein (GSV) qualitatively, and of its tributaries at different stages of varicosis and in other pathological states like thrombophlebitis or phlebosclerosis. Material and methods: 22 patients deserving an aorto-coronary bypass surgery or GSV surgery were subdivided into three groups according to the staging of their varices and other pathology. The harvested GSV were prepared for light and scanning electron microscopy. One cadaverous specimen of GSV was injected with India ink. Results: In specimens from reticular and primary large varices local intimal hyperplasia was regularly found, partially accompanied with a mild increase of VV. Tortuosities and irregular dilations of adventitial veins were also found. In patients with recurrent primary varices or thrombophlebitis severe intimal and medial hyperplasia, thrombosis and a striking increase of VV were found. The intima remained avascular in all cases. Conclusions: Remarkable increase of VV accompanies the most severe forms of varices as well as all cases of the extreme grades of phlebosclerosis, medial hyperplasia and thrombosis. We hypothesize that this increase in VV is rather a secondary vascular reaction to the impaired metabolic conditions within the venous wall than a primary varicogenic factor.

Architectonic Arrangement of the Vasa Vasorum of the Human Great Saphenous Vein

2007 ◽  
Vol 44 (2) ◽  
pp. 157-166 ◽  
Author(s):  
David Kachlik ◽  
Vaclav Baca ◽  
Josef Stingl ◽  
Bohumil Sosna ◽  
Alois Lametschwandtner ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Vasa Vasorum

Characterization of the Vasa Vasorum in the Human Great Saphenous Vein: A Scanning Electron Microscopy and 3D-Morphometry Study Using Vascular Corrosion Casts

2014 ◽  
Vol 20 (4) ◽  
pp. 1120-1133 ◽  
Author(s):  
Markus Herbst ◽  
Thomas Joachim Hölzenbein ◽  
Bernd Minnich
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Three Dimensional ◽  
Coronary Bypass ◽  
Vasa Vasorum ◽  
Corrosion Casts ◽  
Coronary Bypass Grafts ◽  
Scanning Electron

AbstractThe vasa vasorum (VV) of explanted segments of the human great saphenous vein (Vena saphena magna; HGSV), harvested during dissection for coronary bypass grafts or diseased vein segments from the “Salzburger Landesklinikum,” were studied by scanning electron microscopy and three-dimensional morphometry of microvascular corrosion casts. The main objective of this study was to examine the VV’s structural arrangement in order to find the most vital segments of the HGSV and in turn to improve the results of coronary bypass surgeries. The study presents a meticulous analysis of the whole microvascular system of the VV of the HGSV and its three-dimensional arrangement. It is one of the first studies yielding detailed quantitative data on geometry of the VV of the HGSV. A detailed insight into different vascular parameters such as vessel diameter, interbranching, intervascular distances, and branching angles at different levels of the VV’s angioarchitecture and in different parts of the HGSV in health and disease is given. Further, the geometry of bifurcations was examined in order to compute the physiological optimality principles of this delicate vascular system based on its construction, maintenance, and function.

scholarly journals Examination of the Vasa vasorum of the human great saphenous vein: a scanning electron microscopy and 3D-morphometry study of microvascular corrosion casts

2013 ◽  
Vol 19 (S2) ◽  
pp. 18-19
Author(s):  
M. Herbst ◽  
T. Hölzenbein ◽  
B. Minnich
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Vasa Vasorum ◽  
Corrosion Casts ◽  
Scanning Electron

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

scholarly journals The Active Isoforms of MGP Are Expressed in Healthy and Varicose Veins without Calcification

2021 ◽  
Vol 10 (24) ◽  
pp. 5896
Author(s):  
Simona R. Gheorghe ◽  
Cees Vermeer ◽  
Gabriel Olteanu ◽  
Ciprian N. Silaghi ◽  
Alexandra M. Crăciun
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Varicose Veins ◽  
Matrix Gla Protein ◽  
Vasa Vasorum ◽  
Control Group ◽  
Surgical Removal ◽  
Immunohistochemistry Staining ◽  
Before And After ◽  
Tunica Intima

Matrix Gla protein (MGP), a local inhibitor of tissue mineralization, is associated with vascular calcification. Depending on the carboxylation and phosphorylation status, MGP has active conformations, e.g., carboxylated MGP (cMGP) and phosphorylated MGP (pMGP), but also inactive conformations, e.g., uncarboxylated MGP (ucMGP) and dephosphorylated MGP (dpMGP). Our purpose was to assess the presence of all MGP conformations in healthy veins (HV) and varicose veins (VV), concurrently with the analysis of circulating total MGP (tMGP) before and after the surgical stripping of VV. We collected samples from the great saphenous vein, considered as control group, and tissue from VV, designated as VV group. Plasma levels of tMGP were significantly decreased after the surgical removal of the VV (before 59.5 ± 17.2 vs. after 38.1 ± 11.3, p < 0.001). By using immunohistochemistry staining, we identified local cMGP and pMGP in the control and VV groups, both without calcification, while ucMGP and dpMGP were absent. cMGP was observed in the nucleus and cytoplasm and pMGP in the nucleus of cells belonging to the tunica media, tunica intima and vasa vasorum. Therefore, the active conformations of MGP (cMGP and pMGP) are prevalent in HV and VV without calcification, affirming their anti-calcifying role in veins.

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