Syndrome of inappropriate secretion of ADH after administration of intrathecal chemotherapy in acute promyelocytic leukemia with empty sella of pituitary gland

2006 ◽  
Vol 86 (2) ◽  
pp. 149-150 ◽  
Author(s):  
Yutaka Tsutsumi ◽  
Takahito Kawamura ◽  
Souichi Shiratori ◽  
Shinobu Mashiko ◽  
Makoto Ibata ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Acute Promyelocytic Leukemia ◽  
Intrathecal Chemotherapy ◽  
Empty Sella ◽  
Promyelocytic Leukemia ◽  
Inappropriate Secretion

scholarly journals High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Benjamin Powers ◽  
Diane Persons ◽  
Deepthi Rao ◽  
Janet Woodroof ◽  
Tara L. Lin
Keyword(s):  
Complete Remission ◽  
Acute Promyelocytic Leukemia ◽  
Chromosomal Translocation ◽  
Signs And Symptoms ◽  
Intrathecal Chemotherapy ◽  
Promyelocytic Leukemia ◽  
Chromosomal Translocations ◽  
Molecular Testing ◽  
Blood Cell Count ◽  
Central Nervous System Prophylaxis

Acute promyelocytic leukemia (APL) is classically characterized by chromosomal translocation (15;17), resulting in the PML-RARA fusion protein leading to disease. Here, we present a case of a 50-year-old man who presented with signs and symptoms of acute leukemia with concern for APL. Therapy was immediately initiated with all-transretinoic acid. The morphology of his leukemic blasts was consistent with the hypogranular variant of APL. Subsequent FISH and cytogenetic analysis revealed a unique translocation involving five chromosomal regions: 9q34, 17q21, 15q24, 12q13, and 15q26.1. Molecular testing demonstrated PML/RARA fusion transcripts. Treatment with conventional chemotherapy was added and he went into a complete remission. Given his elevated white blood cell count at presentation, intrathecal chemotherapy for central nervous system prophylaxis was also given. The patient remains on maintenance therapy and remains in remission. This is the first such report of a 5-way chromosomal translocation leading to APL. Similar to APL with chromosomal translocations other than classical t(15;17) which result in the typical PML-RARA fusion, our patient responded promptly to an ATRA-containing regimen and remains in complete remission.

Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy

Blood ◽  
2008 ◽  
Vol 112 (9) ◽  
pp. 3587-3590 ◽  
Author(s):  
Wing-Yan Au ◽  
Sidney Tam ◽  
Bonnie M. Fong ◽  
Yok-Lam Kwong
Keyword(s):  
Cerebrospinal Fluid ◽  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Arsenic Concentration ◽  
Intrathecal Chemotherapy ◽  
Promyelocytic Leukemia ◽  
Significant Determinant ◽  
Chemotherapy Treatment ◽  
The Central Nervous System ◽  
Elemental Arsenic

The extent of and factors controlling arsenic penetration into the central nervous system (CNS) remain unclear. Elemental arsenic levels in 67 paired cerebrospinal fluid (CSF) and plasma samples from 9 patients with acute promyelocytic leukemia (APL) on oral arsenic trioxide (As2O3), obtained during intrathecal chemotherapy (treatment of CNS APL, n = 6; prophylaxis, n = 3) were measured. Median arsenic levels of CSF and plasma were 95.8 nmol/L (range, 3.5-318.9 nmol/L) and 498.9 nmol/L (range, 36.3-1892.8 nmol/L). As a group, CSF and plasma arsenic was linearly correlated (P < .001), with CSF at 17.7% the plasma level. The CSF/plasma arsenic ratio, which reflected the arsenic CSF penetration efficiency, varied significantly in individual patients (P < .001). Repeated intrathecal chemotherapy and presence of blasts in CSF did not affect the CSF/plasma arsenic ratio. Plasma arsenic was the only significant determinant of CSF arsenic levels. CSF arsenic was present at therapeutically meaningful levels, implying that As2O3 therapy might be beneficial in CNS APL.

Acute promyelocytic leukemia with a PLZF-RAR[alpha ] fusion protein

2001 ◽  
Vol 38 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Joop H. Jansen ◽  
Bob L[ouml ]wenberg
Keyword(s):  
Fusion Protein ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia

Acute promyelocytic leukemia: Clinical and morphologic features and prognostic factors

2001 ◽  
Vol 38 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Giuseppe Avvisati ◽  
Francesco Lo Coco ◽  
Franco Mandelli
Keyword(s):  
Prognostic Factors ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia

A Case of Therapy-related Myeloid Neoplasm after Successful Treatment of Acute Promyelocytic Leukemia

2011 ◽  
Vol 1 (4) ◽  
pp. 227 ◽  
Author(s):  
Aerin Kwon ◽  
Ji-Young Park ◽  
Jung Hye Kwon ◽  
Hun Ho Song ◽  
Kyu Sung Shin ◽  
...  
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Successful Treatment ◽  
Promyelocytic Leukemia ◽  
Myeloid Neoplasm
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