Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-011-1681-1 ◽

2011 ◽

Vol 69 (1) ◽

pp. 173-183 ◽

Author(s):

Dongchun Wang ◽

Feng Tang ◽

Sen Wang ◽

Zhenzhou Jiang ◽

Luyong Zhang

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Anti Tumor Activity ◽

Tyrosine Kinases Inhibitor

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53LBA A phase I/IIa study of icotinib hydrochloride (BPI-2009H), an oral epidermal growth factor receptor tyrosine kinases inhibitor, in patients with advanced non-small-cell lung cancer and other solid tumors

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(09)72088-9 ◽

2009 ◽

Vol 7 (3) ◽

pp. 22

Author(s):

Q. Zhao ◽

J. Zhou ◽

J. Shentu ◽

L. Wu ◽

N. Xu ◽

...

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Small Cell Lung ◽

Epidermal Growth ◽

Tyrosine Kinases Inhibitor

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148 BAY 57-9352: an inhibitor of VEGFR-2 and PDGFR receptor tyrosine kinases that demonstrates broad anti-tumor activity as a single agent in preclinical models

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(04)80156-3 ◽

2004 ◽

Vol 2 (8) ◽

pp. 47 ◽

Author(s):

Y. Chang ◽

C. Cortes ◽

C. Brink ◽

B. Polony ◽

P. Vincent ◽

...

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Single Agent ◽

Preclinical Models ◽

Anti Tumor Activity

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The anti-angiogenic and anti-tumor activity of synthetic phenylpropenone derivatives is mediated through the inhibition of receptor tyrosine kinases

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.12.012 ◽

2012 ◽

Vol 677 (1-3) ◽

pp. 22-30 ◽

Author(s):

Jong-Suk Lee ◽

Youra Kang ◽

Jong Tae Kim ◽

Dinesh Thapa ◽

Eung-Seok Lee ◽

...

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Anti Tumor Activity

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Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

10.18632/oncotarget.6547 ◽

2015 ◽

Vol 7 (4) ◽

pp. 4093-4109 ◽

Author(s):

Parag P. Patwardhan ◽

Kathryn S. Ivy ◽

Elgilda Musi ◽

Elisa de Stanchina ◽

Gary K. Schwartz

Keyword(s):

Small Molecule ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Small Molecule Inhibitor ◽

Preclinical Models ◽

Molecule Inhibitor ◽

Anti Tumor Activity ◽

Multiple Receptor

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762: Differential Regulation of EPHB4 and EPHB2 Receptor Tyrosine Kinases in Normal Bladder and Bladder Transitional Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)31002-4 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 256-256

Author(s):

Wesley W. Choi ◽

Jeff S. Scehnet ◽

S. Ram Kumar ◽

Charlotte C. Lee ◽

Anne Schuckman ◽

...

Keyword(s):

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Transitional Cell ◽

Differential Regulation ◽

Bladder Transitional Cell Carcinoma ◽

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Increasing PARP inhibitor efficacy in ovarian cancer by targeting receptor tyrosine kinases

10.1055/s-0040-1718153 ◽

2020 ◽

Author(s):

D.M Klotz ◽

J.D Kuhlmann ◽

P Wimberger

Keyword(s):

Ovarian Cancer ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

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Faculty Opinions recommendation of Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001498.201400 ◽

2003 ◽

Author(s):

Guoping Feng

Keyword(s):

Dendritic Spines ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

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Faculty Opinions recommendation of E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1018427.208497 ◽

2004 ◽

Author(s):

Kathleen J Green

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

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Faculty Opinions recommendation of Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13355984.14726088 ◽

2011 ◽

Author(s):

John Maris ◽

David Teachey

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Diffuse Intrinsic Pontine Glioma ◽

Regulatory Genes ◽

Pontine Glioma ◽

Genome Wide ◽

Cell Cycle Regulatory Genes

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Faculty Opinions recommendation of Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726472311.793521055 ◽

2016 ◽

Author(s):

Xiayang Qiu ◽

Ye Che

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Allosteric Inhibition

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