Synthesis of xanthan gum/trimethyl chitosan interpolyelectrolyte complex as pH-sensitive protein carrier

2021 ◽  
Author(s):  
Mahmoud H. Abu Elella ◽  
Demiana H. Hanna ◽  
Riham R. Mohamed ◽  
Magdy W. Sabaa
Keyword(s):  
Xanthan Gum ◽  
Ph Sensitive ◽  
Interpolyelectrolyte Complex ◽  
Protein Carrier ◽  
Trimethyl Chitosan

Antimicrobial pH-sensitive protein carrier based on modified xanthan gum

2020 ◽  
Vol 57 ◽  
pp. 101673
Author(s):  
Mahmoud H. Abu Elella ◽  
MagdyW. Sabaa ◽  
Demiana H. Hanna ◽  
Marwa M. Abdel-Aziz ◽  
Riham R. Mohamed
Keyword(s):  
Xanthan Gum ◽  
Ph Sensitive ◽  
Protein Carrier

Preparation and characterization of folate conjugatedN-trimethyl chitosan nanoparticles as protein carrier targeting folate receptor:in vitrostudies

2009 ◽  
Vol 17 (4) ◽  
pp. 294-303 ◽  
Author(s):  
Yu Zheng ◽  
Zheng Cai ◽  
Xiangrong Song ◽  
Qiuhong Chen ◽  
Yueqi Bi ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Protein Carrier ◽  
Trimethyl Chitosan

scholarly journals Colon Specific Delivery of Indomethacin: Effect of Incorporating pH Sensitive Polymers in Xanthan Gum Matrix Bases

2009 ◽  
Vol 10 (2) ◽  
pp. 418-429 ◽  
Author(s):  
Laila F. A. Asghar ◽  
Chetan B. Chure ◽  
Sajeev Chandran
Keyword(s):  
Xanthan Gum ◽  
Ph Sensitive

scholarly journals INVESTIGATING THE EFFECT OF DIFFERENT GRADES AND CONCENTRATIONS OF PH‑SENSITIVE POLYMER ON PREPARATION AND CHARACTERIZATION OF LIDOCAINE HYDROCHLORIDE AS IN SITU GEL BUCCAL SPRAY

2018 ◽  
Vol 11 (11) ◽  
pp. 401
Author(s):  
Halah Talal Sulaiman ◽  
Saba Abdulhadi Jabir ◽  
Khalid Kadhem Al-kinani
Keyword(s):  
Xanthan Gum ◽  
Buccal Cavity ◽  
Ph Sensitive ◽  
Spray Angle ◽  
Lidocaine Hydrochloride ◽  
In Situ Gel ◽  
Anesthetic Effect ◽  
Spray Solution ◽  
Lidocaine Hcl

Objective: The present study was aimed to develop a pH-triggered in situ gel for local release of lidocaine hydrochloride (lidocaine HCL) in the buccal cavity to improve the anesthetic effect of this amino amide drug which has very high water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration.Methods: In this work, two grades of carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing lidocaine HCl 5% were prepared by mixing different concentrations of carbopol with xanthan gum. Eight formulations were investigated and evaluated for gelation capacity, spray angle, volume of solution delivered per each actuation, rheological properties, and release kinetic model. Similarity factor (f2) was used for the comparison of dissolution profiles.Results: The prepared formulations undergo gelation after it had been actuated to the buccal cavity as a spray solution. The results showed that, as the concentration of polymer was increased, the release of drug decreased and the viscosity increased for both grades. The spray angle and volume of solution delivered per each actuation varied according to the composition of each formulation. The in situ gel containing 0.3% carbopol 934 and 0.2% xanthan gum regarded as a better candidate which had a good gelation and release property compared to other formulations. Drug release from optimized in situ gel spray followed Korsmeyer–Peppas model and was mediated by Fickian diffusion mechanism.Conclusion: Lidocaine HCl-loaded pH-sensitive in situ gel was successfully developed using carbopol 934 as polymer to be applied to the buccal cavity as spray solution for more effective anesthetic effect and painless treatment.

scholarly journals Diphtheria toxoid and N -trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice

2017 ◽  
Vol 262 ◽  
pp. 28-36 ◽  
Author(s):  
Pim Schipper ◽  
Koen van der Maaden ◽  
Vincent Groeneveld ◽  
Mitchel Ruigrok ◽  
Stefan Romeijn ◽  
...  
Keyword(s):  
Immune Responses ◽  
Ph Sensitive ◽  
Diphtheria Toxoid ◽  
Layer By Layer ◽  
Trimethyl Chitosan

Evaluation of pH-Sensitive Poly(β-amino ester)-graft-poly(ethylene glycol) and its Usefulness as a pH-Sensor and Protein Carrier

2011 ◽  
Vol 11 (7) ◽  
pp. 946-951 ◽  
Author(s):  
Min Sang Kim ◽  
Guang Hui Gao ◽  
Seong Woo Kang ◽  
Doo Sung Lee
Keyword(s):  
Ethylene Glycol ◽  
Ph Sensor ◽  
Ph Sensitive ◽  
Amino Ester ◽  
Poly Ethylene Glycol ◽  
Protein Carrier ◽  
Poly Ethylene

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

Langmuir ◽  
2015 ◽  
Vol 31 (31) ◽  
pp. 8654-8660 ◽  
Author(s):  
Koen van der Maaden ◽  
Emine Sekerdag ◽  
Pim Schipper ◽  
Gideon Kersten ◽  
Wim Jiskoot ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Layer By Layer ◽  
Trimethyl Chitosan ◽  
Layer By Layer Assembly ◽  
Layer Assembly

N-Trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery

2009 ◽  
pp. 090526005142032-9 ◽  
Author(s):  
Jinna Cao ◽  
Jukui Sun ◽  
Xiaoyu Wang ◽  
Xinran Li ◽  
Yingjie Deng
Keyword(s):  
Oral Delivery ◽  
Trimethyl Chitosan

Toxicological evaluation of xanthan gum based hydrogel formulation in Wistar rats using single dose study

2020 ◽  
Vol 77 (2) ◽  
pp. 353-360
Author(s):  
Nadia Malik ◽  
Mahmood Ahmad ◽  
Muhammad Minhas ◽  
Ruqia Tulain ◽  
Ikrima Khalid ◽  
...  
Keyword(s):  
Single Dose ◽  
Xanthan Gum ◽  
Wistar Rats ◽  
Toxicological Evaluation ◽  
Single Dose Study ◽  
Dose Study ◽  
Hydrogel Formulation
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