hydrogel formulation
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Agriculture ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 117
Author(s):  
Marcelo A. Guancha-Chalapud ◽  
Liliana Serna-Cock ◽  
Diego F. Tirado

Colombia is the world’s largest producer of fique fibers (Furcraea bedinghausii), with a net production of 30,000 tons per year. This work proposes to revalue waste from the Colombian fique agroindustry. For this purpose, cellulose nanofibers were obtained from fique and used as reinforcement material to create acrylic superabsorbent hydrogels. Unreinforced acrylic hydrogels (AHR0) and acrylic hydrogels reinforced with fique nanofibers at 3% w/w (AHR3), 5% w/w (AHR5), and 10 % w/w (AHR10) were synthesized using the solution polymerization method. The best hydrogel formulation for agricultural purposes was chosen by comparing their swelling behavior, mechanical properties, and using scanning electron microscopy (SEM). By raising the nanofiber concentration to 3% (AHR3), the best-chosen formulation, the interaction between the nanofibers and the polymer matrix increased, which favored the network stability. However, beyond AHR3, there was a higher viscosity of the reactive system, which caused a reduction in the mobility of the polymer chains, thus disfavoring the swelling capacity. The reinforced hydrogel proposed in this study (AHR3) could represent a contribution to overcoming the problems of land dryness present in Colombia, an issue that will worsen in the coming years due to the climate emergency.


Author(s):  
RAMACHANDRAN AM ◽  
SENTHIL PRABHU S ◽  
DEVAKUMAR J ◽  
RENGARAMANUJAM J ◽  
KARTHIK SUNDARAM S ◽  
...  

Objective: The objective of present study was to develop hydrogel formulations loaded with Calotropis gigantea leaves extract. Methods: The prepared hydrogel formulations were compliance with their color, odor, homogeneity, pH, and spreadability. Results: As all the formulations were complies with the all parameters and it can be suggest as a Good antibacterial gel. It is evident that, ethanolic extract of Calotropis gigantea showed a maximum inhibitory zone against bacteria associated with foot ulcer. Conclusions: The In vitro studies showed a quantity dependent increase in antibacterial activity against foot ulcer causing bacteria, a contraction which is higher than that produced by the control groups. These contractions were statistically significant (p<0.05), during the study with leave extract against foot ulcer causing bacteria in diabetes.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1381
Author(s):  
Agnieszka Kostrzębska ◽  
Adrianna Złocińska ◽  
Witold Musiał

Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPRD as well as SEM and macroscopic observations were involved in the study. The TC concentration decreased within ca. two months from 9.37 µg/mL to 4.41 µg/mL in the case of the photoprotected TC solution stored at 23 °C, whereas the decrease in storage temperature did not improve the final level of TC. In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca. 1 µg/mL. Application of a polyacrylic acid derivative enabled conservation of the TC level through the ca. two months. Thus, the use of alcoholamine in the preparation of the TC hydrogel may result in the development of a therapeutic product with a dual action against acne, including antimicrobial activity and saponification of free fatty acids deposited in the follicles.


2021 ◽  
Vol 11 (2) ◽  
pp. 65-71
Author(s):  
PANKAJ KUMAR PANDEY ◽  
◽  
ASHISH KUMAR PARASHAR ◽  

This work aimed to prepare and evaluate the topical liposomal hydrogel to treat antibiotic-resistant propionic bacterium acne. Nadifloxacin-loaded liposomes were prepared by thin-film hydration technique. Nadifloxacin, soya lecithin, cholesterol were dissolved in a mixture of chloroform and taken in different levels, and liposomes were prepared. The prepared liposomes were evaluated for in-vitro drug release. Formulation F2 was the highest percentage entrapment of 71±1.50% and released 58.12±1.2% of the drug in 6hrs. Minocycline hydrochloride-based hydrogel was prepared using the methylcellulose gelling agent, and the drug concentration was kept constant at 0.25%. The concentration of propylene glycol and methylparaben was kept constant at 15% and 0.3%. The hydrogel formulation was evaluated for various physicochemical parameters like percentage drug content, spreadability, and drug release. Formulation H9 was the highest drug content, 98.23 ± 0.031%, and the drug released 90.96±2.6% of the drug in 6hr. Out of these formulations, F2 from liposomes and H9 from hydrogel formula was selected to prepare the final liposomal hydrogel formulation. Developed liposomal hydrogel(F2H9) were evaluated like size, drug content and drug entrapment spreadability, homogeneity, washability, pH, etc. In-vitro drug release from liposomal hydrogel in Nadifloxacin release 54.86±3.1% and Minocycline hydrochloride 91.24±1.82% in 6hr. Developed liposomal hydrogel formulation can better treat acne due to high drug retention and permeation in skin layers. KEYWORDS: Acne, antibiotics, liposomes, hydrogel, Nadifloxacin, Minocycline hydrochloride


Author(s):  
Akhilesh Shewale ◽  
Sneha Pur ◽  
Rashmi Bele ◽  
Mahvash Fatema

Background and Aim: The present study aims to formulate a hydrogel containing Tulsi (O. sanctum) and honey, to obtain a pharmaceutical topical preparation having desirable healing effects and antibacterial properties of both the ingredients. Material and Method: Topical honey hydrogel formulation were prepared using 75%honey and 10% Occimum sanctum (Tulsi) with polymer carbopol 934. The prepared formulation was assessed for its pH, spreadability, swelling index and in-vitro release Result: The pH and spreadability were in the range of 4.74 ± 0.02 and 7.75 ± 0.04 cm respectively. Carbopol based Honey –Tulsi Formulation showed a concentration-dependent increase in the amount of honey and O. sanctum diffused through dialysis method. Conclusion: Within the limitations of the study, the results of our present study suggest that the studied Honey –Tulsi based hydrogel could be an economic indigenous substitute which is non-toxic, natural and efficient for clinical application.


2021 ◽  
Vol 3 (2) ◽  
pp. 55-70
Author(s):  
Noval Noval ◽  
◽  
Yenny Harliantika ◽  

Hydrogel is a topical preparation by applying it to the skin. Agarwood leaf extract is proven to contain flavonoid compounds which play a role in helping the wound healing process. The combination of carbopol and HPMC intend to cover the deficiency of carbopol when used at high concentrations and to provide an acidic ph. Know the influence combination of carbopol base 940 and HPMC K4M and the results of the evaluation of the optimal stability of the hydrogel extract of agarwood leaves. The method used is experimental with true-experimental design. The sample used is agarwood leaves in Tanah Bumbu Regency. Determination, preparation, extraction, hydrogel production and evaluation. Data were analyzed with ANOVA and Kruskal-Wallis statistics. Hydrogel formulation with a combination of carbopol base 940 and HPMC K4M gives an influence on the hydrogel formulation of agarwood leaf extract by evaluating the stability of organoleptic evaluation, homogeneity, pH, viscosity, spreadability and adhesion. The result of the formulation that can maintain the stability of evaluation during storage for 28 days at room temperature is F2. Statistical test results of pH, viscosity, spreadability and adhesion <0.05, p-value <0.05 showed a significant difference in each formula. The influence of a combination of carbopol base 940 and HPMC K4M to the hydrogel formulation of agarwood leaf extract and a good formulation is found in F2.


2021 ◽  
pp. 105636
Author(s):  
Abdoh Taleb ◽  
Ya-Ping Zhou ◽  
Ling-Tong Meng ◽  
Ming-Yi Zhu ◽  
Qiao Zhang ◽  
...  
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