Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies

2019 ◽  
Vol 39 (10) ◽  
pp. 1777-1781 ◽  
Author(s):  
Adam Maundrell ◽  
Susanna Proudman ◽  
Vidya Limaye
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller ◽  
Adam Schiffenbauer
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller ◽  
Adam Schiffenbauer
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

Idiopathic Inflammatory Myopathies

2015 ◽  
Author(s):  
Frederick W Miller
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Clinical Laboratory ◽  
Connective Tissue Diseases ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Pathologic Evaluation

The idiopathic inflammatory myopathies (IIMs), also known as myositis syndromes, are a collection of heterogeneous disorders that share the common feature of chronic muscle inflammation of unknown cause. These disorders may occur in adults or children and are sometimes associated with other connective tissue disorders and a variety of cancers. A combined clinical, laboratory, and pathologic evaluation is needed to establish the diagnosis of these acquired systemic connective tissue diseases to rule out the many disorders that mimic IIMs. This module reviews the classification of IIMs, including polymyositis, dermatomyositis, inclusion body myositis, myositis associated with other connective tissue diseases and cancer, and antisynthetase syndrome. The epidemiology; etiology, genetics, and environmental factors; pathophysiology and pathogenesis; diagnosis; differential diagnosis; treatment; and prognosis of IIMs are discussed. Tables describe the criteria for polymyositis, dermatomyositis, and inclusion body myositis; well-characterized subgroups of the IIMs in adults and children; presentation of polymyositis; differential diagnosis of muscle weakness or pain; features that assist in discriminating IIMs from other myopathies; goals for managing IIMs; and key factors for achieving adequate corticosteroid response in IIMs. Figures demonstrate skin findings in IIMs, muscle pathology of IIMs, magnetic resonance imaging of three patients with different IIMs, and treatment approaches to the management of myositis patients. This review contains 4 highly rendered figures, 8 tables, and 80 references.

scholarly journals The Influence of Dietary Intervention in Connective Tissue Diseases: Evidence from Randomized Clinical Trials

Rheumato ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 5-16
Author(s):  
Francesca Oliviero ◽  
Paola Galozzi ◽  
Elisabetta Zanatta ◽  
Mariele Gatto ◽  
Paolo Spinella ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Randomized Clinical Trials ◽  
Dietary Intervention ◽  
Connective Tissue Diseases ◽  
Short Chain Fatty Acids ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Systemic Lupus

The aim of this review is to identify and discuss randomized clinical trials conducted in patients with connective tissue diseases, including systemic lupus erythematosus, idiopathic inflammatory myopathies, vasculitis, Sjögren’s syndrome, and systemic sclerosis. Although limited, the results obtained with bioactive compounds, namely n-3 polyunsaturated and short-chain fatty acids, demonstrate that dietary intervention and nutritional counseling might have an important role as adjuvant therapy in patients with connective tissue diseases, particularly in the light of the comorbidities which characterize these conditions.

scholarly journals Update on Malignancy in Myositis—Well-Established Association with Unmet Needs

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 111
Author(s):  
Aleksandra H. Opinc ◽  
Joanna S. Makowska
Keyword(s):  
Cancer Screening ◽  
Connective Tissue ◽  
Potential Risk ◽  
Unmet Needs ◽  
Connective Tissue Diseases ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Current State ◽  
Pubmed Database ◽  
Increased Risk

Idiopathic inflammatory myopathies are a group of rare connective tissue diseases with a well-documented association with malignancy. The mechanisms underlying the increased risk of neoplasms in the course of myositis are not fully understood. The Pubmed database has been thoroughly screened for articles concerning cancer-associated myositis (CAM). The article summarizes the current state of knowledge on the epidemiology and pathogenesis of CAM. Furthermore, it analyses potential risk and protective factors for developing CAM, with particular emphasis on the association with distinct serological profiles. The review summarizes recommendations proposed so far for the management of CAM and presents a novel scheme for cancer screening proposed by the authors. Moreover, promising areas requiring further research were indicated.

Inflammatory myopathies

2020 ◽  
pp. 4537-4546
Author(s):  
Ingrid E. Lundberg ◽  
Hector Chinoy ◽  
Robert Cooper
Keyword(s):  
Gastrointestinal Tract ◽  
Connective Tissue ◽  
Muscle Fibre ◽  
Inclusion Body Myositis ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Necrotizing Myopathy ◽  
Immune Mediated ◽  
Heterogenous Group ◽  
Muscle Biopsies

The idiopathic inflammatory myopathies are a heterogenous group of disorders characterized by muscle weakness, inflammation in muscle tissue, and with frequent extramuscular involvement. Autoantibodies are common, supporting the notion of these disorders being autoimmune. Typically, inflammatory cell infiltrates are found in muscle biopsies. Other organs are frequently involved such as skin, lungs, joints, gastrointestinal tract, and the heart. These heterogenous disorders can be subclassified based on clinical and histopathological features, or by autoantibody specificities. The idiopathic inflammatory myopathies have traditionally comprised polymyositis (PM), dermatomyositis (DM), juvenile DM, PM/DM overlapping with another connective tissue disease, and inclusion body myositis. More recently a subgroup with similar clinical features but with no or scarce inflammation and with pronounced muscle fibre necrosis has been identified and termed immune-mediated necrotizing myopathy.

scholarly journals The Correlation of Muscle Biopsy Scores with the Clinical Variables in Idiopathic Inflammatory Myopathies

2016 ◽  
Vol 10 (1) ◽  
pp. 141-149 ◽  
Author(s):  
Suparaporn Wangkaew ◽  
Songkiet Suwansirikul ◽  
Kantawut Aroonrungwichian ◽  
Nuntana Kasitanon ◽  
Worawit Louthrenoo
Keyword(s):  
Connective Tissue ◽  
Muscle Biopsy ◽  
Muscle Power ◽  
Demographic Data ◽  
Muscle Pathology ◽  
Idiopathic Inflammatory Myopathies ◽  
Muscle Degeneration ◽  
Inflammatory Myopathies ◽  
Muscle Biopsies ◽  
Modest Correlation

Objectives: To compare the muscle pathology findings among subgroups of idiopathic inflammatory myopathies (IIM) patients, and to determine the correlations of muscle biopsy scores with muscle power and creatine kinase (CK). Methods: The medical records of IIM patients consisting of the demographic data, clinical parameters and laboratory conducted were retrospectively reviewed. Their initial muscle biopsies were reviewed, and four domains were scored: inflammation, vascular, muscle, and connective tissue. Results: Ninety-five IIM patients (28 patients with idiopathic polymyositis (PM) 9 idiopathic dermatomyositis (DM), 5 DM associated with malignancy, and 53 PM/DM associated with connective tissue disease) with median (IQR: Q1, Q3) disease duration of 1.2 (0.5, 3.1) months were included. No significant differences in initial muscle pathology findings and muscle pathology score among the subgroups were found. Muscle degeneration and endomysial fibrosis scores were negatively correlated with muscle power (r=-0.23 and-0.24, respectively, p<0.05) and positively correlated with CK (r=0.27 and 0.39, respectively, p<0.01). No significant correlation was detected either inflammation or vasculitis scores with muscle power and CK levels. Conclusion: In this study, muscle biopsy cannot be used to differentiate among subgroups of IIM patients. In addition, we found only modest correlation of muscle biopsy scores with muscle power and CK. Further study is necessary to confirm our findings.

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