Real-time monitoring of radiofrequency ablation of liver tumors using thermal-dose calculation by MR temperature imaging: initial results in nine patients, including follow-up

Abstract Objectives The objectives of this study were to determine the primary technique effectiveness (PTE), to compare the complete response and local recurrence rates between conspicuous and inconspicuous tumors using single and switching electrodes of real-time virtual sonography (RVS)-assisted radiofrequency ablation (RFA) in conspicuous and inconspicuous hepatic tumors under conventional ultrasonography (US). Subjects and method We compared the complete ablation of inconspicuous tumors with and without anatomical landmark (N = 54) with conspicuous liver tumors (N = 272). Conventional US imaging was done initially, and then these images were fused with CT or MRI arterial-venous-wash-out cross-sectional studies and synchronized with real-time US images. Results RVS-assisted RFA was technically feasible in all patients. The PTE rate after the first ablation was 94% (245/261) for conspicuous tumors, 88% (7/8) in inconspicuous tumors with landmark, and 78% (36/46) in inconspicuous tumors without landmark. The complete response (p = 0.1912 vs. p = 0.4776) and local recurrence rate (p = 0.1557 vs. p = 0.7982) were comparable in conspicuous tumors of both HCC and liver metastasis group when single or multiple switching was used. The cumulative local recurrence in the conspicuous and inconspicuous tumors of the HCC group (p = 0.9999) was almost parallel after 12 (10% vs. 4%) and 24 (13% vs. 4%) months of follow-up. In the liver metastasis group, the cumulative local recurrence for conspicuous tumors (p = 0.9564) was nearly equal after 12 and 24 months of monitoring (24% vs. 27%) while no recurrence was incurred for the inconspicuous tumors. Conclusion RVS-assisted RFA is an effective tool for the treatment of conspicuous and inconspicuous HCC and hepatic metastasis.

Download Full-text

Real time monitoring of radiofrequency ablation based on MR thermometry and thermal dose in the pig liver in vivo

European Radiology ◽

10.1007/s00330-007-0761-4 ◽

2007 ◽

Vol 18 (2) ◽

pp. 408-416 ◽

Cited By ~ 43

Author(s):

Olivier Seror ◽

Matthieu Lepetit-Coiffé ◽

Brigitte Le Bail ◽

Baudouin Denis de Senneville ◽

Hervé Trillaud ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Real Time ◽

Thermal Dose ◽

Real Time Monitoring ◽

Mr Thermometry ◽

Pig Liver

Download Full-text

328 RADIOFREQUENCY ABLATION FOR KIDNEY TUMORS: A WAY OF A REAL-TIME MONITORING

European Urology Supplements ◽

10.1016/s1569-9056(09)60332-8 ◽

2009 ◽

Vol 8 (4) ◽

pp. 202

Author(s):

M. Salagierski ◽

M.S. Salagierski ◽

T. Konecki ◽

W. Różański

Keyword(s):

Radiofrequency Ablation ◽

Real Time ◽

Real Time Monitoring ◽

Kidney Tumors

Download Full-text

Microwave Versus Radiofrequency Ablation for the Treatment of Liver Malignancies: A Randomized Controlled Phase 2 Trial

10.21203/rs.3.rs-508761/v1 ◽

2021 ◽

Author(s):

Aleksandar Radosevic ◽

Rita Quesada ◽

Clara Serlavos ◽

Juan Sánchez ◽

Ander Zugazaga ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Liver Tumors ◽

Statistical Significance ◽

Phase 2 ◽

Liver Malignancies ◽

Phase 2 Trial ◽

Primary Endpoints ◽

Phase 2 Clinical Trial ◽

Ablative Techniques

Abstract Purpose: Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA in medium-sized liver tumors.Methods: HCC and MT patients with 1.5 to 4 cm tumors suitable for ablation were randomized into MWA or RFA Groups. The primary endpoints were primary technical success (TS) and local tumor progression (LTP) rate after a 2-year follow-up. Secondary endpoints were safety and overall survival. Results: Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, three patients were excluded. Median follow-up was 27 months (MWA group) and 23 months (RFA Group). The TS was achieved in 98% (46/47) and 90 % (45/50) (p=0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66-5.3], p=0.238) of tumors in the MWA and RFA Group, respectively. Major complications were found in 5 cases (11%) in the MWA Group vs. 2 cases (4%) in RFA, without statistical significance. MWA created larger ablation zones than RFA (p=0.036).Conclusion: MWA and RFA show similar effectiveness and safety in medium-sized liver tumors (1.5-4 cm).

Download Full-text

Study on Tracking in Interested Moving Objects

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.382.418 ◽

2011 ◽

Vol 382 ◽

pp. 418-421

Author(s):

Dong Yan Cui ◽

Zai Xing Xie

Keyword(s):

Computational Complexity ◽

Real Time ◽

Monitoring System ◽

Moving Objects ◽

Moving Object ◽

Experimental Results ◽

Real Time Monitoring ◽

Automatic Program ◽

Inter Frame

This paper presents an automatic program to track in moving objects, using segmentation algorithm quickly and efficiently after the division of a moving object, in the follow-up frame through the establishment of inter-frame vectors to track moving objects of interest. Experimental results show that the algorithm can accurately and effectively track moving objects of interest, and because the algorithm is simple, the computational complexity is small, can be well positioned to meet real-time monitoring system in the extraction of moving objects of interest and tracking needs.

Download Full-text