scholarly journals Respiratory anomalies associated with gadoxetate disodium and gadoterate meglumine: compressed sensing MRI revealing physiologic phenomena during the entire injection cycle

2021 ◽  
Author(s):  
Carl Guillaume Glessgen ◽  
Hanns-Christian Breit ◽  
Tobias Kai Block ◽  
Elmar Max Merkle ◽  
Tobias Heye ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Temporal Correlation ◽  
Arterial Phase ◽  
Phase Imaging ◽  
Gadoxetate Disodium ◽  
Respiratory Events ◽  
Cardiac Ventricle ◽  
Gadoterate Meglumine ◽  
Time Changes ◽  
The Right

Abstract Objectives The goal of this study was to investigate the precise timeline of respiratory events occurring after the administration of two gadolinium-based contrast agents, gadoxetate disodium and gadoterate meglumine. Materials and methods This retrospective study examined 497 patients subject to hepatobiliary imaging using the GRASP MRI technique (TR/TE = 4/2 ms; ST = 2.5 mm; 384 × 384 mm). Imaging was performed after administration of gadoxetate (N = 338) and gadoterate (N = 159). All GRASP datasets were reconstructed using a temporal resolution of 1 s. Four regions-of-interest (ROIs) were placed in the liver dome, the right and left cardiac ventricle, and abdominal aorta detecting liver displacement and increasing vascular signal intensities over time. Changes in hepatic intensity reflected respiratory dynamics in temporal correlation to the vascular contrast bolus. Results In total, 216 (67%) and 41 (28%) patients presented with transient respiratory motion after administration of gadoxetate and gadoterate, respectively. The mean duration from start to acme of the respiratory episode was similar (p = 0.4) between gadoxetate (6.0 s) and gadoterate (5.6 s). Its mean onset in reference to contrast arrival in the right ventricle differed significantly (p < 0.001) between gadoxetate (15.3s) and gadoterate (1.8 s), analogously to peak inspiration timepoint in reference to the aortic enhancement arrival (gadoxetate: 0.9s after, gadoterate: 11.2 s before aortic enhancement, p < 0.001). Conclusions The timepoint of occurrence of transient respiratory anomalies associated with gadoxetate disodium and gadoterate meglumine differs significantly between both contrast agents while the duration of the event remains similar. Key Points • Transient respiratory anomalies following the administration of gadoterate meglumine occurred during a time period usually not acquired in MR imaging. • Transient respiratory anomalies following the administration of gadoxetate disodium occurred around the initiation of arterial phase imaging. • The estimated duration of respiratory events was similar between both contrast agents.

Artifacts during the arterial phase of gadoxetate disodium-enhanced MRI: Multiple arterial phases using view-sharing from two different vendors versus single arterial phase imaging

2018 ◽  
Vol 28 (8) ◽  
pp. 3335-3346 ◽  
Author(s):  
Ji Hye Min ◽  
Young Kon Kim ◽  
Tae Wook Kang ◽  
Woo Kyoung Jeong ◽  
Won Jae Lee ◽  
...  
Keyword(s):  
Arterial Phase ◽  
Phase Imaging ◽  
Gadoxetate Disodium ◽  
View Sharing ◽  
Enhanced Mri

scholarly journals Uterine Intravenous Leiomyomatosis with Cardiac Extension: Radiologic Assessment with Surgical and Pathologic Correlation

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Go Nakai ◽  
Kazuya Maeda ◽  
Kazuhiro Yamamoto ◽  
Takashi Yamada ◽  
Yoshinobu Hirose ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Vena Cava ◽  
Mass Range ◽  
Arterial Phase ◽  
Phase Imaging ◽  
Ovarian Vein ◽  
Pathologic Correlation ◽  
Contrast Enhanced Ct ◽  
Cardiac Extension ◽  
The Right

We present the computed tomography (CT) and magnetic resonance (MR) imaging findings of a 71-year-old woman with a cardiac extension of intravenous leiomyoma (IVL) that arose from the uterus, extended to the inferior vena cava (IVC), and reached the right ventricle through the right ovarian vein. Radiologic-pathologic correlation showed that the intravascular cord-like mass originating from the IVC and extending to the right ventricle was composed of degenerated smooth muscle cells with a number of large vessels that were regarded as arteries; moreover, the arteries within the cord-like mass appeared to be looping internally. Given the disappearance of the right ovarian venous wall around the IVL pathologically, extracting the tumor from the ovarian vein during an operation is considered to be impossible retrospectively. Also it was difficult to identify even the intravenous extension of the uterine leiomyoma histopathologically. Therefore, contrast-enhanced CT, in particular arterial phase imaging, provided important information that revealed the mass, range, and path of the lesion, ensuring that an appropriate operative plan could be drawn up and the tumor completely excised.

scholarly journals Analytical Interference by Contrast Agents in Biochemical Assays

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Sigrid Otnes ◽  
Niels Fogh-Andersen ◽  
Janne Rømsing ◽  
Henrik S. Thomsen
Keyword(s):  
Lactate Dehydrogenase ◽  
Contrast Agents ◽  
Blood Test ◽  
Test Results ◽  
Gadoxetate Disodium ◽  
Negative Interference ◽  
Analytical Interference ◽  
Biochemical Assays ◽  
Gadoterate Meglumine ◽  
Positive Interference

Objective.To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements.Materials and Methods.The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0.5 mM and 12 mg iodine/mL, respectively. Subsequently, 12 assays were reexamined using1/2and1/4of these CA concentrations. The results were assessed statistically by a paired Student’st-test.Results.Iodixanol produced a negative interference on the bicarbonate (p=0.011), lactate dehydrogenase (p<0.0001), and zinc (p=0.0034) assays and a positive interference on the albumin (p=0.0062), calcium (p<0.0001), ionized calcium (p=0.0086), iron (p<0.0001), and potassium (p=0.0003) assays. Iomeprol produced a negative interference on the bicarbonate (p=0.0057) and magnesium (p=0.0001) assays and a positive interference on the calcium (p<0.0001) and potassium (p=0.0012) assays. Gadoxetate disodium produced a negative interference on the iron (p<0.0001) and zinc (p<0.0001) assays and a positive interference on the sodium (p=0.032) assay.Conclusion.CAs cause analytical interference. Attention should be given to the above-mentioned analyte-CA combinations when assessing laboratory blood test results obtained after CA administration.

scholarly journals Primary Gastrointestinal Stromal Tumor of the Liver with Cystic Changes

2019 ◽  
Vol 13 (1) ◽  
pp. 58-65
Author(s):  
Takashi Tashiro ◽  
Fumihiro Uwamori ◽  
Yukiomi Nakade ◽  
Tadahisa Inoue ◽  
Yuji Kobayashi ◽  
...  
Keyword(s):  
Liver Tumors ◽  
Past History ◽  
Brain Infarction ◽  
Arterial Phase ◽  
First Case ◽  
Positron Emission ◽  
Cystic Changes ◽  
Multiple Bone Metastases ◽  
The Right ◽  
Cells Of Cajal

Gastrointestinal stromal tumors (GISTs) are known to originate specifically from the intestinal cells of Cajal located in the gastrointestinal mesenchyme. GISTs developing outside of the digestive tract have barely been reported. We encountered a first case of large primary GISTs in the liver with cystic changes. A 63-year-old man with a past history of brain infarction visited our hospital. The computed tomography (CT) revealed a 6-cm and a 10-cm mass in the right and the caudal lobe of the liver, respectively. These tumors have marginal enhancement in the arterial phase; however, they presented as hypodense in the internal tumor sites. Both liver tumors had cystic changes. Gastrointestinal examinations using endoscopy revealed no other gastrointestinal tumors, and [18F]-fluoro-2-deoxy-D-glucose positron emission tomography/CT revealed multiple bone metastases in addition to the liver tumors. The liver tumor specimens were composed of spindle cells, and the immunohistochemical staining for c-Kit and for DOG1, as discovered on GIST, was positive. The patient was diagnosed with primary hepatic GIST with cystic changes.

scholarly journals 346. Head to Toe Imaging of Complications and Sequelae of COVID- 19 and COVID-19 Vaccination

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S277-S278
Author(s):  
Deepti H Vijayakumar ◽  
Deepali Saxena ◽  
Rajesh V Helavar ◽  
Raghavendra Tirupathi
Keyword(s):  
Neurological Complications ◽  
Hypercoagulable State ◽  
Ground Glass ◽  
Arterial Phase ◽  
Cardiac Complications ◽  
Fungal Sinusitis ◽  
Gastrointestinal Complications ◽  
Secondary Infections ◽  
The Right ◽  
Lung Window

Abstract Background COVID 19 is associated with a hypercoagulable state with cytokine storm syndrome and thrombocytopenia leading to complications across various systems. COVID-19 infection, its treatment, resultant immunosuppression, and pre-existing comorbidities have made patients vulnerable to secondary infections Methods We systematically reviewed COVID-19 cases between Jan to May 2021 for pulmonary and extrapulmonary complications. Patients with recent COVID-19 vaccination and neurological symptoms were also included. Figure 1. “Black turbinate” sign of mucormycosis Contrast enhanced coronal T1 FS images of paranasal sinuses shows necrotic non-enhancing right superior and middle turbinates (*) with extension into the right orbital fat. FIGURE 2 - A composite image of Coronal CT of upper abdomen in arterial phase and lung bases in lung window showing wedge showing right renal infarcts (line arrow) due to inferior polar artery thrombosis and ground glass opacities (solid arrow) in lung bases. Results Neurological complications: Neurological complications include ischemic and haemorrhagic strokes. Other complications are encephalopathy, encephalitis, Guillain-Barré syndrome, acute hemorrhagic necrotizing encephalopathy. Demyelination and radiculopathies are seen as post vaccination complications. Mucormycosis: Unprecedented high rate of invasive fungal sinusitis in association with COVID -19 is reported from the Indian subcontinent. This has a propensity for intra orbital and intracranial extension. COVID -19 associated coagulopathy: COVID -19 is a pro-inflammatory hypercoagulable state. Pulmonary thromboembolism, deep venous thrombosis and catheter related thrombosis are well documented. Cardiac complications: Cardiac manifestations include Myocardial Injury with non-obstructed coronary arteries (MINOCA), myocarditis, myocardial ischemia, cardiomyopathy. Pulmonary complications and sequelae of COVID -19: Progression of lung injury to ARDS during the initial phase and fibrosis of parenchyma in the recovery phase. Spontaneous pneumomediastinum, pneumatoceles and pneumothorax and secondary infections are identified in our study. COVID- 19 associated gastrointestinal complications: Patients evaluated for renal colic, pancreatitis, cholecystitis showed, ground glass opacities or subpleural bands in typical Covid-19 distribution. COVID-19 may lead of acute kidney and bowel injury due to arterial thrombosis. COVID - 19 associated myonecrosis: Ischemia of the small caliber vessels may result in myonecrosis. FIGURE 3 - Coronal STIR image shows thickened and hyperintense trunks and divisions of the right brachial plexus suggestive of plexopathy in a COVID -19 patient with H/O recent COVID-19 vaccination. Figure 4. Axial CT chest section in lung window showing pneumothorax (white arrow) and pneumatocele ( grey arrow) with peripheral ground glass opacities and consolidations in both lungs. Conclusion Awareness of these unusual manifestations will facilitate an early diagnosis, improve management and help reduce morbidity and mortality Disclosures All Authors: No reported disclosures

Case 17.10

2014 ◽  
pp. 811-812
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Equilibrium Phase ◽  
Arterial Phase ◽  
Hepatic Lobe ◽  
The Right

54-year-old man with cirrhosis Axial precontrast 3D SPGR image (Figure 17.10.1A) demonstrates a nodular hepatic contour and moderate splenomegaly. Postgadolinium arterial (Figure 17.10.1B), portal venous (Figure 17.10.1C), and equilibrium phase (Figure 17.10.1D) images reveal a finger superimposing the left side of the abdomen (and pointing toward 2 arterial phase enhancing nodules in the periphery of the right hepatic lobe). Axial 2D SPGR image (...

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