scholarly journals DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes

2001 ◽  
Vol 12 (6) ◽  
pp. 456-461 ◽  
Author(s):  
Weizhen Ji ◽  
Feng Chen ◽  
Trang Do ◽  
Anh Do ◽  
Bruce A. Roe ◽  
...  

1999 ◽  
Vol 10 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Anthony G. Brickner ◽  
Ben F. Koop ◽  
Bruce J. Aronow ◽  
Dan A. Wiginton


Genomics ◽  
1995 ◽  
Vol 25 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Jane E. Lamerdin ◽  
Mishelle A. Montgomery ◽  
Stephanie A. Stilwagen ◽  
Lisa K. Scheidecker ◽  
Robert S. Tebbs ◽  
...  


Development ◽  
2002 ◽  
Vol 129 (5) ◽  
pp. 1205-1213
Author(s):  
Robert A. Drewell ◽  
Katharine L. Arney ◽  
Takahiro Arima ◽  
Sheila C. Barton ◽  
James D. Brenton ◽  
...  

The reciprocally imprinted H19 and Igf2 genes form a co-ordinately regulated 130 kb unit in the mouse controlled by widely dispersed enhancers, epigenetically modified silencers and an imprinting control region (ICR). Comparative human and mouse genomic sequencing between H19 and Igf2 revealed two novel regions of strong homology upstream of the ICR termed H19 upstream conserved regions (HUCs). Mouse HUC1 and HUC2 act as potent enhancers capable of driving expression of an H19 reporter gene in a range of mesodermal tissues. Intriguingly, the HUC sequences are also transcribed bi-allelically in mouse and human, but their expression pattern in neural and endodermal tissues in day 13.5 embryos is distinct from their enhancer function. The location of the HUC mesodermal enhancers upstream of the ICR and H19, and their capacity for interaction with both H19 and Igf2 requires critical re-evaluation of the cis-regulation of imprinted gene expression of H19 and Igf2 in a range of mesodermal tissues. We propose that these novel sequences interact with the ICR at H19 and the epigenetically regulated silencer at differentially methylated region 1 (DMR1) of Igf2.



Nature ◽  
10.1038/16495 ◽  
1999 ◽  
Vol 397 (6715) ◽  
pp. 176-180 ◽  
Author(s):  
Richard A. Alm ◽  
Lo-See L. Ling ◽  
Donald T. Moir ◽  
Benjamin L. King ◽  
Eric D. Brown ◽  
...  


1999 ◽  
Vol 105 (1-2) ◽  
pp. 17-27 ◽  
Author(s):  
F. von Deimling ◽  
J.M. Scharf ◽  
T. Liehr ◽  
M. Rothe ◽  
A.-R. Kelter ◽  
...  




1991 ◽  
Vol 66 (03) ◽  
pp. 315-320 ◽  
Author(s):  
Aruna Pawashe ◽  
Michael Ezekowitz ◽  
Tsung-Chung Lin ◽  
Renata Horton ◽  
Ronald Bach ◽  
...  

SummaryTissue factor (TF) is a membrane anchored glycoprotein that initiates blood coagulation by forming a complex with circulating factor VII or VIIa. TF has been identified in atherosclerotic plaques and may possibly trigger thrombosis after spontaneous plaque rupture as seen in acute myocardial infarction or angioplasty. We have previously developed an atherosclerotic rabbit model for study of the acute and chronic outcomes following angioplasty. As a first step in developing inhibitors of TF, we have isolated and characterized a rabbit cDNA coding for the mature TF. The sequence comparison of rabbit TF cDNA with those of human and mouse TFs show considerable similarity at both the nucleotide and amino acid levels. The TF cDNA when expressed in E. coli demonstrates a procoagulant activity comparable to that of native rabbit brain TF. The TF activity can be blocked by a polyclonal antibody against rabbit TF.



2011 ◽  
Vol 21 (3) ◽  
pp. 487-493 ◽  
Author(s):  
S. M. Kielbasa ◽  
R. Wan ◽  
K. Sato ◽  
P. Horton ◽  
M. C. Frith


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