Genomic sequence comparison of the human and mouse adenosine deaminase gene regions

1999 ◽  
Vol 10 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Anthony G. Brickner ◽  
Ben F. Koop ◽  
Bruce J. Aronow ◽  
Dan A. Wiginton
Keyword(s):  
Adenosine Deaminase ◽  
Sequence Comparison ◽  
Genomic Sequence ◽  
Human And Mouse

scholarly journals DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes

2001 ◽  
Vol 12 (6) ◽  
pp. 456-461 ◽  
Author(s):  
Weizhen Ji ◽  
Feng Chen ◽  
Trang Do ◽  
Anh Do ◽  
Bruce A. Roe ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Sequence Comparison ◽  
Genomic Sequence ◽  
Dependent Atpase ◽  
Human And Mouse

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions

Genomics ◽  
1995 ◽  
Vol 25 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Jane E. Lamerdin ◽  
Mishelle A. Montgomery ◽  
Stephanie A. Stilwagen ◽  
Lisa K. Scheidecker ◽  
Robert S. Tebbs ◽  
...  
Keyword(s):  
Dna Repair ◽  
Sequence Comparison ◽  
Genomic Sequence ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Human And Mouse

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

Nature ◽  
10.1038/16495 ◽  
1999 ◽  
Vol 397 (6715) ◽  
pp. 176-180 ◽  
Author(s):  
Richard A. Alm ◽  
Lo-See L. Ling ◽  
Donald T. Moir ◽  
Benjamin L. King ◽  
Eric D. Brown ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Sequence Comparison ◽  
Genomic Sequence ◽  
Gastric Pathogen

DNA sequence comparison of human and mouse retinitis pigmentosa GTPase regulator (RPGR) identifies tissue-specific exons and putative regulatory elements

2001 ◽  
Vol 109 (3) ◽  
pp. 271-278 ◽  
Author(s):  
Renate Kirschner ◽  
Deniz Erturk ◽  
Christina Zeitz ◽  
Selen Sahin ◽  
Juliane Ramser ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Dna Sequence ◽  
Sequence Comparison ◽  
Regulatory Elements ◽  
Tissue Specific ◽  
Retinitis Pigmentosa Gtpase Regulator ◽  
Human And Mouse ◽  
Dna Sequence Comparison

Molecular Cloning, Characterization and Expression of cDNA for Rabbit Brain Tissue Factor

1991 ◽  
Vol 66 (03) ◽  
pp. 315-320 ◽  
Author(s):  
Aruna Pawashe ◽  
Michael Ezekowitz ◽  
Tsung-Chung Lin ◽  
Renata Horton ◽  
Ronald Bach ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Sequence Comparison ◽  
Plaque Rupture ◽  
Rabbit Model ◽  
Factor Vii ◽  
Rabbit Brain ◽  
Atherosclerotic Plaques ◽  
E Coli ◽  
Amino Acid Levels ◽  
Human And Mouse

SummaryTissue factor (TF) is a membrane anchored glycoprotein that initiates blood coagulation by forming a complex with circulating factor VII or VIIa. TF has been identified in atherosclerotic plaques and may possibly trigger thrombosis after spontaneous plaque rupture as seen in acute myocardial infarction or angioplasty. We have previously developed an atherosclerotic rabbit model for study of the acute and chronic outcomes following angioplasty. As a first step in developing inhibitors of TF, we have isolated and characterized a rabbit cDNA coding for the mature TF. The sequence comparison of rabbit TF cDNA with those of human and mouse TFs show considerable similarity at both the nucleotide and amino acid levels. The TF cDNA when expressed in E. coli demonstrates a procoagulant activity comparable to that of native rabbit brain TF. The TF activity can be blocked by a polyclonal antibody against rabbit TF.

scholarly journals Adaptive seeds tame genomic sequence comparison

2011 ◽  
Vol 21 (3) ◽  
pp. 487-493 ◽  
Author(s):  
S. M. Kielbasa ◽  
R. Wan ◽  
K. Sato ◽  
P. Horton ◽  
M. C. Frith
Keyword(s):  
Sequence Comparison ◽  
Genomic Sequence

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification

Blood ◽  
2004 ◽  
Vol 104 (10) ◽  
pp. 3106-3116 ◽  
Author(s):  
Veronica Valverde-Garduno ◽  
Boris Guyot ◽  
Eduardo Anguita ◽  
Isla Hamlett ◽  
Catherine Porcher ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Sequence Comparison ◽  
Regulatory Element ◽  
Cis Elements ◽  
Enhancer Activity ◽  
Cis Element ◽  
Human Sequence ◽  
Human And Mouse

Abstract Cis-element identification is a prerequisite to understand transcriptional regulation of gene loci. From analysis of a limited number of conserved gene loci, sequence comparison has proved a robust and efficient way to locate cis-elements. Human and mouse GATA1 genes encode a critical hematopoietic transcription factor conserved in expression and function. Proper control of GATA1 transcription is critical in regulating myeloid lineage specification and maturation. Here, we compared sequence and systematically mapped position of DNase I hypersensitive sites, acetylation status of histone H3/H4, and in vivo binding of transcription factors over approximately 120 kilobases flanking the human GATA1 gene and the corresponding region in mice. Despite lying in approximately 10 megabase (Mb) conserved syntenic segment, the chromatin structures of the 2 homologous loci are strikingly different. The 2 previously unidentified hematopoietic cis-elements, one in each species, are not conserved in position and sequence and have enhancer activity in erythroid cells. In vivo, they both bind the transcription factors GATA1, SCL, LMO2, and Ldb1. More broadly, there are both species- and regulatory element–specific patterns of transcription factor binding. These findings suggest that some cis-elements regulating human and mouse GATA1 genes differ. More generally, mouse human sequence comparison may fail to identify all cis-elements.

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