Optical Coherence Tomography: its role in the non-invasive structural examination and conservation of cultural heritage objects—a review

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

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Non-invasive characterization of microstructured optical fibers using Fourier domain optical coherence tomography

Optics Express ◽

10.1364/opex.13.001228 ◽

2005 ◽

Vol 13 (4) ◽

pp. 1228 ◽

Cited By ~ 5

Author(s):

J. C. Jasapara

Keyword(s):

Optical Coherence Tomography ◽

Optical Fibers ◽

Fourier Domain ◽

Optical Coherence ◽

Non Invasive ◽

Microstructured Optical Fibers

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Line‐field confocal optical coherence tomography for non‐invasive diagnosis of lichenoid dermatoses of the childhood: A case series

Skin Research and Technology ◽

10.1111/srt.13075 ◽

2021 ◽

Author(s):

Linda Tognetti ◽

Andrea. Carraro ◽

Elisa Cinotti ◽

Mariano Suppa ◽

Veronique Marmol ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Case Series ◽

Optical Coherence ◽

Line Field ◽

Non Invasive

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Results of the project «Optimization of the process of obtaining the service OCT “ (project implementation period 20.06.2019–08.10.2019)

Medsestra (Nurse) ◽

10.33920/med-05-2109-03 ◽

2021 ◽

pp. 29-37

Author(s):

Irina Aleksandrovna Rakitina ◽

Alfiya Gumyarovna Iskhakova ◽

Evgeny Andreevich Zamytsky ◽

Marina Vladimirovna Makolina ◽

Farida Sagitovna Goleeva ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Contact Method ◽

Optical Coherence ◽

Non Invasive ◽

Risk Of Injury ◽

Eye Tissues ◽

Implementation Period ◽

Project Optimization ◽

Theoretical Foundations

Optical Coherence Tomography (OCT) is a modern, highly accurate, non-invasive study of various eye structures. OCT is a non-contact method that allows a specialist to visualize eye tissue with a very high resolution (1–15 microns), the accuracy of which is comparable to microscopic examination. The theoretical foundations of the OCT method were developed in 1995 by the American ophthalmologist K. Pulafito, and already in 1996–1997 Carl Zeiss Meditec introduced the first device for optical coherence tomography into clinical practice. Today, OCT devices are used to diagnose various diseases of the fundus and anterior segment of the eye. Due to the maximum accuracy, the method of light scanning greatly simplifies the diagnosis of pathologies of the organs of vision, regardless of the cause of their occurrence and the stage of the course. In terms of information content, the technique is not inferior to histology, but the advantage of OCT is the absence of the risk of injury to the eye tissues [1, 2].

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