The aim of the study is to study the structure and dynamics of changes in the labor motivation of medical workers at the stages of professional activity and to suggest ways to improve the labor motivation management system in a medical organization. Results. Based on the theoretical conclusions and the research conducted, recommendations were developed to improve the system for managing the labor motivation of the personnel of a medical organization, which, on the one hand, take into account the features of the motivational complex specific to each group of medical workers, and on the other hand, changes in the structure of motivation that occur as the acquisition of professional experience by specialists. Conclusion. The study showed that as medical workers accumulate work experience, their motivational spectrum shifts towards external motives, thus, their internal motivation decreases.