Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene

2000 ◽  
Vol 18 (2) ◽  
pp. 125-129 ◽  
Author(s):  
Moshe Shalev ◽  
Brian J. Miles ◽  
Timothy C. Thompson ◽  
Gustavo Ayala ◽  
Edward B. Butler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Thymidine Kinase ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Thymidine Kinase Gene ◽  
Kinase Gene

Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene

Surgery ◽  
1998 ◽  
Vol 123 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Héléna Nagy ◽  
Yves Panis ◽  
Monique Fabre ◽  
Hubert Perrin ◽  
David Klatzmann ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Experimental Study ◽  
Thymidine Kinase ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Good Target

scholarly journals The war against cancer: Suicide gene therapy

2016 ◽  
Vol 2 (3) ◽  
pp. 139
Author(s):  
Muzeyyen Izmirli ◽  
Dilara Sonmez ◽  
Bulent Gogebakan
Keyword(s):  
Gene Therapy ◽  
Cytochrome P450 ◽  
Side Effects ◽  
Cancer Cells ◽  
Thymidine Kinase ◽  
Viral Vectors ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Kinase Gene ◽  
Cancer Society

<p>The National Cancer Institute and the American Cancer Society announced that 1.6 million new cancer cases are projected to occur in the USA in 2016. One of the most innovative approaches against cancer is suicide gene therapy, in which suicide-inducing transgenes are introduced into cancer cells. When cancer treatments target the total elimination of tumor cells, there will be no side effects for normal cells. Cancer tissues are targeted through various targeted transport methods, followed by tissue-specific enzymes converting a systemically suitable prodrug into an active drug in the tumor. Suicidal genes are delivered by transporters, such as viral and non-viral vectors, into cancer cells. Suicide gene therapeutic strategies currently pursued are herpes simplex virus thymidine kinase gene with prodrug ganciclovir, cytosine deaminase gene, carboxyl esterase/irinotecan, varicella zoster virus thymidine kinase/6-methoxypurine arabinonucleoside, nitroreductase Nfsb/5-(aziridin-1-yl)-2,4-dinitrobenzamide, carboxypeptidase G2/4-[(2-chloroethyl)(2- mesyloxyethyl)amino]benzoyl-L-glutamic acid, cytochrome p450-isofosfamide, and cytochrome p450-cyclophosphamide. The goal of this review is to summarize the different suicide gene systems and gene delivery vectors addressed to cancer cells, with a particular emphasis on recently developed systems. Finally, we briefly describe the advantageous clinical applications and potential side effects of suicide gene therapy. </p>

Potent Bystander Effect in Suicide Gene Therapy Using Neural Stem Cells Transduced with Herpes Simplex Virus Thymidine Kinase Gene

Oncology ◽  
2005 ◽  
Vol 69 (6) ◽  
pp. 503-508 ◽  
Author(s):  
Shaoyi Li ◽  
Tsutomu Tokuyama ◽  
Junkoh Yamamoto ◽  
Masayo Koide ◽  
Naoki Yokota ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Simplex Virus

Optimizing Prostate Cancer Suicide Gene Therapy Using Herpes Simplex Virus Thymidine Kinase Active Site Variants

2002 ◽  
Vol 13 (7) ◽  
pp. 777-789 ◽  
Author(s):  
Allan J. Pantuck ◽  
Jamie Matherly ◽  
Amnon Zisman ◽  
David Nguyen ◽  
Frank Berger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Active Site ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Simplex Virus
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