The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

2005 ◽  
Vol 21 (3) ◽  
pp. 201-208 ◽  
Author(s):  
M. Davies ◽  
S. Gupta ◽  
G. Goldspink ◽  
M. Winslet
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Experimental Evidence ◽  
Insulin Like Growth Factor ◽  
Factor System

scholarly journals Isolated Isoflavones Do Not Affect the Circulating Insulin-Like Growth Factor System in Men at Increased Colorectal Cancer Risk

2007 ◽  
Vol 137 (2) ◽  
pp. 379-383 ◽  
Author(s):  
Alina Vrieling ◽  
Matti A. Rookus ◽  
Ellen Kampman ◽  
Johannes M. G. Bonfrer ◽  
Catharina M. Korse ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Factor System

scholarly journals No Effect of Red Clover-Derived Isoflavone Intervention on the Insulin-Like Growth Factor System in Women at Increased Risk of Colorectal Cancer

2008 ◽  
Vol 17 (10) ◽  
pp. 2585-2593 ◽  
Author(s):  
A. Vrieling ◽  
M. A. Rookus ◽  
E. Kampman ◽  
J. M.G. Bonfrer ◽  
A. Bosma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Red Clover ◽  
Insulin Like Growth Factor ◽  
Increased Risk ◽  
Factor System

The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge

2005 ◽  
Vol 20 (3) ◽  
pp. 203-220 ◽  
Author(s):  
Rajaraman Durai ◽  
Wenxuan Yang ◽  
Sharmila Gupta ◽  
Alexander M. Seifalian ◽  
Marc C. Winslet
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Current Knowledge ◽  
Insulin Like Growth Factor ◽  
Cancer Review ◽  
Factor System

scholarly journals The insulin-like growth factor system: A target for endocrine disruptors?

2021 ◽  
Vol 147 ◽  
pp. 106311
Author(s):  
Chiara Talia ◽  
Lisa Connolly ◽  
Paul A. Fowler
Keyword(s):  
Growth Factor ◽  
Endocrine Disruptors ◽  
Insulin Like Growth Factor ◽  
System A ◽  
Factor System

scholarly journals IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Chenyang Qiao ◽  
Wenjie Huang ◽  
Jie Chen ◽  
Weibo Feng ◽  
Tongyue Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Cancer Metastasis ◽  
Combined Treatment ◽  
Insulin Like Growth Factor ◽  
Atp Citrate Lyase ◽  
Citrate Lyase ◽  
Elevated Expression ◽  
Igf1r Inhibitor ◽  
Colorectal Cancer Metastasis

AbstractMetastasis is the major reason for the high mortality of colorectal cancer (CRC) patients and its molecular mechanism remains unclear. Here, we report a novel role of Homeobox A13 (HOXA13), a member of the Homeobox (HOX) family, in promoting CRC metastasis. The elevated expression of HOXA13 was positively correlated with distant metastasis, higher AJCC stage, and poor prognosis in two independent CRC cohorts. Overexpression of HOXA13 promoted CRC metastasis whereas downregulation of HOXA13 suppressed CRC metastasis. Mechanistically, HOXA13 facilitated CRC metastasis by transactivating ATP-citrate lyase (ACLY) and insulin-like growth factor 1 receptor (IGF1R). Knockdown of ACLY and IGFIR inhibited HOXA13-medicated CRC metastasis, whereas ectopic overexpression of ACLY and IGFIR rescued the decreased CRC metastasis induced by HOXA13 knockdown. Furthermore, Insulin-like growth factor 1 (IGF1), the ligand of IGF1R, upregulated HOXA13 expression through the PI3K/AKT/HIF1α pathway. Knockdown of HOXA13 decreased IGF1-mediated CRC metastasis. In addition, the combined treatment of ACLY inhibitor ETC-1002 and IGF1R inhibitor Linsitinib dramatically suppressed HOXA13-mediated CRC metastasis. In conclusion, HOXA13 is a prognostic biomarker in CRC patients. Targeting the IGF1-HOXA13-IGF1R positive feedback loop may provide a potential therapeutic strategy for the treatment of HOXA13-driven CRC metastasis.

scholarly journals Vitamin D and the insulin‐like growth factor system: Implications for colorectal neoplasia

2020 ◽  
Vol 50 (9) ◽  
Author(s):  
George Ciulei ◽  
Olga Hilda Orasan ◽  
Sorina Cezara Coste ◽  
Angela Cozma ◽  
Vasile Negrean ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Colorectal Neoplasia ◽  
Insulin Like Growth Factor ◽  
Factor System
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