Erratum to: The prognostic factors of stage IV colorectal cancer and assessment of proper treatment according to the patient’s status

Abstract Background: This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC).Methods: Subjects were 996 patients with stage IV CRC who were referred to the National Cancer Center Hospital between 2001 and 2015. We retrospectively investigated correlations between OS and CONUT score, PNI, and mGPS. Multivariate analyses were performed using Cox proportional hazards regression models.Results: After adjusting for known factors (age, gender, BMI, ECOG performance status, location of primary tumor, CEA levels, histological type, M category, and prior surgical treatment), all three measures were found to be independent prognostic factors for OS in patients with stage IV CRC (CONUT score, p<0.001; PNI, p<0.001; mGPS, p<0.001). Significant differences in OS were found between low CONUT score (0/1) (n=614; 61%) and intermediate CONUT score (2/3) (n=276; 28%) (hazard ratio (HR)=1.20, 95% confidence interval (CI): 1.02-1.42, p=0.032), and intermediate CONUT score and high CONUT score (≥4) (n=106; 11%) (HR=1.30, 95% CI: 1.01-1.67, p=0.045). Significant differences in OS were found between mGPS=0 (n=633; 64%) and mGPS=1 (n=234; 23%) (HR=1.84, 95% CI: 1.54-2.19, p<0.001), but not between mGPS=1 and mGPS=2 (n=129; 13%) (HR=1.12, 95% CI: 0.88-1.41, p=0.349). Patients with low PNI (<48.0) (n=443; 44%) showed a significantly lower OS rate than those with high PNI (≥48.0) (n=553; 56%) (HR=1.39, 95% CI: 1.19-1.62, p<0.001).Conclusions: CONUT score, PNI, and mGPS were found to be independent prognostic factors for OS in patients with stage IV CRC, suggesting that nutritional and inflammatory status is a useful host-related prognostic indicator in stage IV CRC.

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Systematic Review of Prognostic Factors Related to Overall Survival in Patients with Stage IV Colorectal Cancer and Unresectable Metastases

World Journal of Surgery ◽

10.1007/s00268-010-0891-8 ◽

2010 ◽

Vol 35 (3) ◽

pp. 684-692 ◽

Cited By ~ 54

Author(s):

Andrew P. Stillwell ◽

Yik-Hong Ho ◽

Craig Veitch

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Overall Survival ◽

Prognostic Factors ◽

Stage Iv ◽

Stage Iv Colorectal Cancer ◽

Unresectable Metastases

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Nomogram for predicting overall survival in colorectal cancer with distant metastasis

BMC Gastroenterology ◽

10.1186/s12876-021-01692-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zheng Liu ◽

Yao Xu ◽

Guijun Xu ◽

Vladimir P. Baklaushev ◽

Vladimir P. Chekhonin ◽

...

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Prognostic Factors ◽

Cancer Patients ◽

Distant Metastasis ◽

Primary Tumour ◽

Stage Iv ◽

Cox Proportional Hazards ◽

Stage Iv Colorectal Cancer ◽

Colorectal Cancer Patients

Abstract Background Colorectal cancer (CRC) is a major cancer burden, and prognosis is determined by many demographic and clinicopathologic factors. The present study aimed to construct a prognostic nomogram for colorectal cancer patients with distant metastasis. Methods Colorectal cancer patients with distant metastasis diagnosed between 2010 and 2016 were selected from the Surveillance, Epidemiology, and End Results database. Cox proportional hazards regression was used to identify independent prognostic factors. A nomogram was constructed to predict survival, and validation was performed. Results A total of 7099 stage IV colorectal cancer patients were enrolled in the construction cohort. The median overall survival was 20.0 (95% CI 19.3–20.7) months. Age at diagnosis, marital status, race, primary tumour site, tumour grade, CEA level, T stage, N stage, presence of bone, brain, liver and lung metastasis, surgery for primary site and performance of chemotherapy were independent prognostic factors. The nomogram was constructed and the calibration curve showed satisfactory agreement. The C-index was 0.742 (95% CI 0.726–0.758). In the validation cohort (7098 patients), the nomogram showed satisfactory discrimination and calibration with a C-index of 0.746 (95% CI 0.730–0.762). Conclusion A series of factors associated with the survival of CRC patients with distant metastasis were found. Based on the identified factors, a nomogram was generated to predict the survival of stage IV colorectal cancer patients. The predictive model showed satisfactory discrimination and calibration, which can provide a reference for survival estimation and individualized treatment decisions.

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Clinicopathological Study on the Prognostic Factors of stage IV Colorectal Cancer

The Japanese Journal of Gastroenterological Surgery ◽

10.5833/jjgs.39.529 ◽

2006 ◽

Vol 39 (5) ◽

pp. 529-535 ◽

Cited By ~ 1

Author(s):

Akihisa Matsuda ◽

Kiyonori Furukawa ◽

Hideaki Takasaki ◽

Hideyuki Suzuki ◽

Hayato Kan ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Stage Iv ◽

Stage Iv Colorectal Cancer ◽

Clinicopathological Study

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Prognostic Factors of Patients Who Underwent Primary Tumor Resection in Stage IV Colorectal Cancer with Non-resectable Synchronous Metastasis

Nippon Daicho Komonbyo Gakkai Zasshi ◽

10.3862/jcoloproctology.66.585 ◽

2013 ◽

Vol 66 (8) ◽

pp. 585-590

Author(s):

Yusuke Katayama ◽

Manabu Shiozawa ◽

Sho Sawazaki ◽

Koji Numata ◽

Masakatsu Numata ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Primary Tumor ◽

Tumor Resection ◽

Stage Iv ◽

Primary Tumor Resection ◽

Synchronous Metastasis ◽

Stage Iv Colorectal Cancer

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Nutritional and Inflammatory Measures Predict Survival of Patients with Stage IV Colorectal Cancer

10.21203/rs.3.rs-39821/v3 ◽

2020 ◽

Author(s):

Yasuyuki Takamizawa ◽

Dai Shida ◽

Narikazu Boku ◽

Yuya Nakamura ◽

Yuka Ahiko ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Prognostic Score ◽

Glasgow Prognostic Score ◽

Stage Iv ◽

Cancer Center ◽

Prognostic Impact ◽

Stage Iv Colorectal Cancer ◽

Inflammatory Status ◽

Conut Score

Abstract Background: This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS)) on overall survival (OS) in patients with stage IV colorectal cancer (CRC).Methods: Subjects were 996 patients with stage IV CRC who were referred to the National Cancer Center Hospital between 2001 and 2015. We retrospectively investigated correlations between OS and CONUT score, PNI, and mGPS. Multivariate analyses were performed using Cox proportional hazards regression models.Results: After adjusting for known factors (age, gender, BMI, ECOG performance status, location of primary tumor, CEA levels, histological type, M category, and prior surgical treatment), all three measures were found to be independent prognostic factors for OS in patients with stage IV CRC (CONUT score, p<0.001; PNI, p<0.001; mGPS, p<0.001). Significant differences in OS were found between low CONUT score (0/1) (n=614; 61%) and intermediate CONUT score (2/3) (n=276; 28%) (hazard ratio (HR)=1.20, 95% confidence interval (CI): 1.02-1.42, p=0.032), and intermediate CONUT score and high CONUT score (≥4) (n=106; 11%) (HR=1.30, 95% CI: 1.01-1.67, p=0.045). Significant differences in OS were found between mGPS=0 (n=633; 64%) and mGPS=1 (n=234; 23%) (HR=1.84, 95% CI: 1.54-2.19, p<0.001), but not between mGPS=1 and mGPS=2 (n=129; 13%) (HR=1.12, 95% CI: 0.88-1.41, p=0.349). Patients with low PNI (<48.0) (n=443; 44%) showed a significantly lower OS rate than those with high PNI (≥48.0) (n=553; 56%) (HR=1.39, 95% CI: 1.19-1.62, p<0.001).Conclusions: CONUT score, PNI, and mGPS were found to be independent prognostic factors for OS in patients with stage IV CRC, suggesting that nutritional and inflammatory status is a useful host-related prognostic indicator in stage IV CRC.

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