Relationship between therapeutic time intervals and intermediate term left ventricular systolic function in patients treated with facilitated percutaneous coronary intervention for acute myocardial infarction

2006 ◽  
Vol 96 (2) ◽  
pp. 94-102 ◽  
Author(s):  
Philipp Meyborg ◽  
Mohamed Abdel-Wahab ◽  
Gunhild Herrmann ◽  
Volker Geist ◽  
Ahmed A. Khattab ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Ventricular Systolic Function ◽  
Time Intervals ◽  
Percutaneous Coronary

Abstract 499: Lower Diastolic Wall Strain Is Associated With Percutaneous Coronary Intervention in Patients With Normal Left Ventricular Systolic Function

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Min-Kyung Kang ◽  
Soo Ho Kim ◽  
Jaehuk Choi ◽  
Hee-Sun Mun ◽  
Seonghoon Choi ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Ventricular Systolic Function ◽  
Normal Left Ventricular ◽  
Diastolic Wall Strain ◽  
Percutaneous Coronary ◽  
Echocardiographic Parameters

Background: Left ventricular (LV) diastolic dysfunction occurs before LV systolic dysfunction and electrocardiographic changes in ischemic cascade. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to defined the relationship between DWS and percutaneous coronary intervention (PCI) and see other echocardiographic parameters in patients who undergoing coronary angiography (CAG). Methods: 254 patients (mean age: 61 ± 10, 136 (54%) men) undergoing CAG and normal left ventricular systolic function without regional wall motion abnormalities were enrolled, and among them, 68 (27%) patients performed PCI. All patients performed echocardiography before CAG and DWS defined using posterior wall thickness (PWT) measurements from standard echocardiographic images (DWS =[PWT(systole)-PWTdiastole)]/PWT(systole)). Results: Patients who performed PCI showed significantly lower DWS (0.27 ± 0.09 vs. 0.39 ± 0.08, p < 0.001). Age did not differ between the two groups (61.6 ± 10.6 vs. 60.9 ± 10.4, p = 0.623), and LV ejection fraction was also similar (62.8 ± 4.6 vs. 63.5 ± 5.2%, p = 0.380). Other echocardiographic parameters did not show significance differences but E/E’ ratio was slightly but significantly elevated in patients performed PCI (10.9 ± 4.8 vs 9.2 ± 3.3, p = 0.011). In multiple regression analysis, lower DWS was an independent predictor for PCI (Cut-off value: 0.34, sensitivity: 89%, AUC: 0.870, SE: 0.025, p < 0.001). Conclusion: DWS, a simple parameter that can be calculated from routine 2D echocardiography, is inversely associated with presence of coronary artery disease and PCI.

scholarly journals Association between Peak Neutrophil Count, Clopidogrel Loading Dose, and Left Ventricular Systolic Function in Patients with Primary Percutaneous Coronary Intervention

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xinyu Wang ◽  
Haiyi Yu ◽  
Zhaoping Li ◽  
Liuning Li ◽  
Youyi Zhang ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Neutrophil Count ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Loading Dose ◽  
Ventricular Systolic Function ◽  
Percutaneous Coronary

Inflammation plays an important role in plaque development and left ventricular remodeling during acute myocardial infarction (AMI). Clopidogrel may exhibit some anti-inflammatory properties and high loading dose of clopidogrel results in improved clinical outcomes in patients with AMI. 357 patients who received successful primary percutaneous coronary intervention from January 2008 to March 2011 in Peking University Third Hospital were included in this study. Different loading dose of clopidogrel (300 mg, 450 mg, or 600 mg) was given at the discretion of the clinician. Neutrophils reached their peak values on the first day after AMI. Higher levels of peak neutrophil and lower left ventricular ejection fraction (LVEF) were found in patients of low clopidogrel loading dose group (300 mg or 450 mg). After adjusting for the related confounders, a logistic regression model showed that low clopidogrel loading dose remained an independent predictor of low LVEF (LVEF ≤ 50%) [OR: 1.97, 95% CI: 1.03–3.79,P= 0.04]. Low clopidogrel loading dose was associated with higher peak neutrophil count and poor left ventricular systolic function, suggesting an important role of clopidogrel loading dose in the improvement of left ventricular function and high loading dose may exhibit better anti-inflammatory properties.

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