A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: results of the “MIMOSA” randomized clinical trial

2021 ◽  
Author(s):  
Michael Georgoulis ◽  
Nikos Yiannakouris ◽  
Roxane Tenta ◽  
Elizabeth Fragopoulou ◽  
Ioanna Kechribari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Clinical Trial ◽  
Mediterranean Diet ◽  
Lifestyle Intervention ◽  
Obstructive Sleep ◽  
And Oxidative Stress

scholarly journals Obstructive Sleep Apnea after Weight Loss: A Clinical Trial Comparing Gastric Bypass and Intensive Lifestyle Intervention

2013 ◽  
Vol 09 (05) ◽  
pp. 427-432 ◽  
Author(s):  
Jan Magnus Fredheim ◽  
Jan Rollheim ◽  
Rune Sandbu ◽  
Dag Hofsø ◽  
Torbjørn Omland ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Gastric Bypass ◽  
Sleep Apnea ◽  
Lifestyle Intervention ◽  
Intensive Lifestyle Intervention ◽  
Obstructive Sleep

scholarly journals Cardiometabolic Benefits of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in Patients with Obstructive Sleep Apnea: The “MIMOSA” Randomized Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1570 ◽  
Author(s):  
Michael Georgoulis ◽  
Nikos Yiannakouris ◽  
Ioanna Kechribari ◽  
Kallirroi Lamprou ◽  
Eleni Perraki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Relative Risk ◽  
Sleep Apnea ◽  
Mediterranean Diet ◽  
Lifestyle Intervention ◽  
Standard Care ◽  
Adjusted Relative Risk ◽  
Obstructive Sleep

Although continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA), its cardiometabolic benefits are questionable. Our aim was to explore whether the combination of a weight-loss Mediterranean diet/lifestyle intervention with OSA standard care leads to greater cardiometabolic improvements compared with standard care alone. We randomly assigned 187 adult, overweight, polysomnography-diagnosed moderate-to-severe OSA patients to a standard care group (SCG, n = 65), a Mediterranean diet group (MDG, n = 62) or a Mediterranean lifestyle group (MLG, n = 60). All three groups were prescribed with CPAP. Additionally, the SCG only received brief written healthy lifestyle advice, while intervention arms were subjected to a six-month weight-loss behavioral intervention based on the Mediterranean diet. The MLG also received guidance for improving physical activity and sleep habits. Glucose metabolism indices, blood lipids, liver enzymes and blood pressure improved only in intervention arms, and were significantly lower compared to the SCG post-intervention (all p < 0.05). The age-, sex-, baseline- and CPAP use-adjusted relative risk (95% confidence interval) of metabolic syndrome was 0.58 (0.34–0.99) for the MDG and 0.30 (0.17–0.52) for the MLG compared to the SCG. The MLG additionally presented a lower relative risk of metabolic syndrome compared to the MDG (0.52 (0.30–0.89)). After further adjustment for body-weight change, a lower relative risk of metabolic syndrome was still evident for the MLG compared to the SCG. In conclusion, although standard care alone does not improve OSA patients’ cardiometabolic profile, its combination with a weight-loss Mediterranean diet/lifestyle intervention leads to significant cardiometabolic benefits.

scholarly journals A Comparison of Uvulopalatopharyngoplasty and Modified Radiofrequency Tissue Ablation in Mild to Moderate Obstructive Sleep Apnea: A Randomized Clinical Trial

2017 ◽  
Vol 13 (09) ◽  
pp. 1089-1096 ◽  
Author(s):  
Amin Amali ◽  
Maziar Motiee-Langroudi ◽  
Babak Saedi ◽  
Sara Rahavi-Ezabadi ◽  
Ali Karimian ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Clinical Trial ◽  
Tissue Ablation ◽  
Obstructive Sleep
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