d-Gluconic acid–based methotrexate prodrug–loaded mixed micelles composed of MDR reversing copolymer: in vitro and in vivo results

2018 ◽  
Vol 296 (12) ◽  
pp. 1971-1981 ◽  
Author(s):  
Popat S. Kumbhar ◽  
Swapnil Birange ◽  
Mahesh Atavale ◽  
John I. Disouza ◽  
Arehalli S. Manjappa
Keyword(s):  
Gluconic Acid ◽  
Mixed Micelles

Mixed Micelles as Nano Polymer Therapeutics of Docetaxel: Increased In vitro Cytotoxicity and Decreased In vivo Toxicity

2018 ◽  
Vol 15 (4) ◽  
pp. 564-575 ◽  
Author(s):  
Arehalli S. Manjappa ◽  
Popat S. Kumbhar ◽  
Prajakta S. Khopade ◽  
Ajit B. Patil ◽  
John I. Disouza
Keyword(s):  
Mixed Micelles ◽  
In Vitro Cytotoxicity ◽  
Polymer Therapeutics ◽  
In Vivo Toxicity

Development and evaluation of a novel drug delivery: Soluplus®/TPGS mixed micelles loaded with piperine in vitro and in vivo

2018 ◽  
Vol 44 (9) ◽  
pp. 1409-1416 ◽  
Author(s):  
Yingying Ding ◽  
Changyuan Wang ◽  
Yutong Wang ◽  
Youwei Xu ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mixed Micelles ◽  
Novel Drug

scholarly journals Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery

2018 ◽  
Vol 82 (2) ◽  
pp. 238-246 ◽  
Author(s):  
Zhen Lu ◽  
Cuiping Bu ◽  
Weicheng Hu ◽  
Hui Zhang ◽  
Mengrui Liu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Mixed Micelles ◽  
In Vivo Evaluation

scholarly journals Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation

2013 ◽  
pp. 1463 ◽  
Author(s):  
Xiaoling Fang ◽  
Chen ◽  
Xianyi Sha ◽  
Zhang ◽  
Zhong ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Mixed Micelles ◽  
In Vivo Evaluation

Influence of taurocholate, taurochenodeoxycholate, and taurodehydrocholate on sulfobromophthalein transport into bile.

1979 ◽  
Vol 236 (1) ◽  
pp. E10
Author(s):  
S Binet ◽  
Y Delage ◽  
S Erlinger
Keyword(s):  
Bile Salts ◽  
Mixed Micelle ◽  
Mixed Micelles ◽  
Important Determinant ◽  
Micelle Formation ◽  
Similar Increase ◽  
Mixed Micelle Formation ◽  
Series Of Experiments

To test the hypothesis that incorporation of sulfobromophthalein (BSP) into mixed micelles could account for the increase in its biliary transport maximum (Tmax) by bile salts, we have compared in hamsters the influence on BSP Tmax of taurocholate and taurochenodeoxycholate (two micelle-forming physiological bile salts) to that of taurodehydrocholate, a bile salt which, in vitro, does not form micelles. In a first series of experiments, it was observed that taurocholate and taurochenodeoxycholate increased the secretion of phospholipid (40 and 53%, respectively), and cholesterol (50 and 110%, respectively), whereas taurodehydrocholate decreased the secretion of phospholipid (-31%) and cholesterol (-43%). This result suggests that, in vivo, taurodehydrocholate or its metabolites do not form mixed micelles. In a second series of experiments, it was seen that the three bile salts induced a similar increase in BSP Tmax (63% with taurocholate, 52% with taurochenodeoxycholate, and 51% with taurodehydrocholate). These results provide circumstantial evidence for the hypothesis that mixed micelle formation is not an important determinant of maximal BSP secretion into bile.

scholarly journals Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation

Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 1369-1377
Author(s):  
Xiaojing Xia ◽  
Jin Tao ◽  
Zhuwa Ji ◽  
Chencheng Long ◽  
Ying Hu ◽  
...  
Keyword(s):  
Mixed Micelles ◽  
Antitumor Efficacy ◽  
Ginsenoside Rh2 ◽  
In Vitro Evaluation

scholarly journals Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 546 ◽  
Author(s):  
Shuichi Setoguchi ◽  
Ryoji Hidaka ◽  
Nami Nagata-Akaho ◽  
Daisuke Watase ◽  
Mitsuhisa Koga ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Mixed Micelles ◽  
Active Form ◽  
Liver Microsomes ◽  
Micelle Solution ◽  
20 Nm ◽  
Ubiquinone 10 ◽  
Derivatives Of

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine ester derivatives of UqH-10, including a 1-monoester (UqH-1-DMG), 4-monoester (UqH-4-DMG), and 1,4-bis-ester (UqH-DMG), and assessed their physicochemical properties in vitro and in vivo. UqH-DMG spontaneously formed an aqueous micelle solution comprising 20 nm particles at 36.5 °C. Cationic UqH-DMG formed nano-sized (5 nm) mixed-micelles with taurocholic acid. Reconversion of the derivatives to UqH-10 was accelerated in human liver microsomes. The oral bioavailability of UqH-10 after administration of UqH-derivatives or Uq-10 was determined in fasted and postprandial rats secreting normal and high levels of bile, respectively. In fasted rats, plasma UqH-10 after UqH-derivatives administration reached Cmax at 2–3 h and after Uq-10 administration, it remained low. The AUC0-24h of UqH-10 after UqH-derivatives administration was 2–3-fold higher than that after Uq-10 administration. In postprandial rats, the Tmax of UqH-10 after UqH-derivatives administration was an hour earlier than after Uq-10 administration. In conclusion, cationic UqH-derivatives are convenient prodrugs that enhance UqH-10 bioavailability by forming nanosized mixed-micelles with intestinal bile acids.

In Vitro and in Vivo Characterization of Hydroxyapatite/Chitosan-Gluconic Acid Conjugate Scaffolds

2017 ◽  
Vol 50 (7) ◽  
pp. 577-582 ◽  
Author(s):  
Takayuki Takei ◽  
Kohei Fukumoto ◽  
So Danjo ◽  
Takuma Yoshinaga ◽  
Hiroto Nishimata ◽  
...  
Keyword(s):  
Gluconic Acid ◽  
Acid Conjugate

Mixed Micelles Formulation for Carvedilol Delivery: in-vitro Characterization and in-vivo Evaluation

2021 ◽  
pp. 121294
Author(s):  
Kıvılcım Öztürk ◽  
Fatma Betül Arslan ◽  
Süleyman Can Öztürk ◽  
Sema Çalış
Keyword(s):  
Mixed Micelles ◽  
In Vivo Evaluation ◽  
In Vitro Characterization
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