Polyhedral oligomeric silsesquioxane-capped poly(N-vinyl pyrrolidone) amphiphiles: synthesis, self-assembly, and use as porogen of nanoporous poly(vinylidene fluoride)

2018 ◽  
Vol 297 (1) ◽  
pp. 141-153 ◽  
Author(s):  
Yanhao Zhang ◽  
Bingjie Zhao ◽  
Lei Li ◽  
Kangming Nie ◽  
Sixun Zheng
Keyword(s):  
Self Assembly ◽  
Vinylidene Fluoride ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Vinyl Pyrrolidone ◽  
Poly Vinylidene Fluoride ◽  
Oligomeric Silsesquioxane

scholarly journals Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane–Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 184 ◽  
Author(s):  
Hyo-Geun Jeong ◽  
Yoon-Soo Han ◽  
Kyung-Hye Jung ◽  
Young-Jin Kim
Keyword(s):  
Composite Nanofibers ◽  
Vinylidene Fluoride ◽  
Epigallocatechin Gallate ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Bone Tissue Regeneration ◽  
Β Phase ◽  
Poly Vinylidene Fluoride ◽  
Anti Inflammatory ◽  
Oligomeric Silsesquioxane

To provide adequate conditions for the regeneration of damaged bone, it is necessary to develop piezoelectric porous membranes with antioxidant and anti-inflammatory activities. In this study, composite nanofibers comprising poly(vinylidene fluoride) (PVDF) and a polyhedral oligomeric silsesquioxane–epigallocatechin gallate (POSS–EGCG) conjugate were fabricated by electrospinning methods. The resulting composite nanofibers showed three-dimensionally interconnected porous structures. Their average diameters, ranging from 936 ± 223 nm to 1094 ± 394 nm, were hardly affected by the addition of the POSS–EGCG conjugate. On the other hand, the piezoelectric β-phase increased significantly from 77.4% to 88.1% after adding the POSS–EGCG conjugate. The mechanical strength of the composite nanofibers was ameliorated by the addition of the POSS–EGCG conjugate. The results of in vitro bioactivity tests exhibited that the proliferation and differentiation of osteoblasts (MC3T3-E1) on the nanofibers increased with the content of POSS–EGCG conjugate because of the improved piezoelectricity and antioxidant and anti-inflammatory properties of the nanofibers. All results could suggest that the PVDF composite nanofibers were effective for guided bone regeneration.

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