Circle of Willis atherosclerosis: association with Alzheimer’s disease, neuritic plaques and neurofibrillary tangles

2006 ◽  
Vol 113 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Thomas G. Beach ◽  
Jeffrey R. Wilson ◽  
Lucia I. Sue ◽  
Amanda Newell ◽  
Marissa Poston ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Circle Of Willis ◽  
Neuritic Plaques

scholarly journals Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease

2004 ◽  
Vol 165 (2) ◽  
pp. 523-531 ◽  
Author(s):  
Huishan Guo ◽  
Steffen Albrecht ◽  
Martine Bourdeau ◽  
Tracy Petzke ◽  
Catherine Bergeron ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Neuritic Plaques ◽  
Neuropil Threads ◽  
Caspase 6 ◽  
Active Caspase

scholarly journals Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ralph Michael ◽  
Aufried Lenferink ◽  
Gijs F. J. M. Vrensen ◽  
Ellen Gelpi ◽  
Rafael I. Barraquer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Tissue ◽  
Neurofibrillary Tangles ◽  
Raman Imaging ◽  
Neuritic Plaques

scholarly journals Hypertension and Alzheimer’s disease: indirect effects through circle of Willis atherosclerosis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Graham M L Eglit ◽  
Alexandra J Weigand ◽  
Daniel A Nation ◽  
Mark W Bondi ◽  
Katherine J Bangen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Indirect Effects ◽  
Arterial Wall ◽  
Circle Of Willis ◽  
Cerebral Hypoperfusion ◽  
Vascular Risk ◽  
Neuritic Plaques ◽  
Continuous Measures

Abstract Hypertension is common among older adults and is believed to increase susceptibility to Alzheimer’s disease, but mechanisms underlying this relationship are unclear. Hypertension also promotes circle of Willis atherosclerosis, which contributes to cerebral hypoperfusion and arterial wall stiffening, two potential mechanisms linking hypertension to Alzheimer’s disease. To examine the role of circle of Willis atherosclerosis in the association between hypertension and Alzheimer’s disease neuropathology, we analysed post-mortem neuropathological data on 2198 decedents from the National Alzheimer’s Coordinating Center database [mean (standard deviation) age at last visit 80.51 (1.95) and 47.1% female] using joint simultaneous (i.e. mediation) modelling. Within the overall sample and among Alzheimer’s dementia decedents, hypertension was indirectly associated with increased neuritic plaques and neurofibrillary tangles through its association with circle of Willis atherosclerosis. Similar indirect effects were observed for continuous measures of systolic and diastolic blood pressure. These results suggest that hypertension may promote Alzheimer’s disease pathology indirectly through intracranial atherosclerosis by limiting cerebral blood flow and/or dampening perivascular clearance. Circle of Willis atherosclerosis may be an important point of convergence between vascular risk factors, cerebrovascular changes and Alzheimer’s disease neuropathology.

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