Predictive value of pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG on fetal growth restriction: results of a prospective study

2015 ◽  
Vol 293 (6) ◽  
pp. 1227-1233 ◽  
Author(s):  
Pietro Cignini ◽  
Laura Maggio Savasta ◽  
Ferdinando Antonio Gulino ◽  
Salvatore Giovanni Vitale ◽  
Lucia Mangiafico ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fetal Growth ◽  
Plasma Protein ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Protein A ◽  
Growth Restriction ◽  
Beta Hcg ◽  
A Prospective Study

scholarly journals Pregnancy associated plasma protein A: an early predictor of fetal growth restriction

2021 ◽  
Vol 10 (12) ◽  
pp. 4517
Author(s):  
Pavan Bhargava Chandramohan ◽  
Sarita Agrawal ◽  
Chandrashekhar Shrivastava ◽  
Sarita Rajbhar ◽  
Prasanta Nayak ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Plasma Protein ◽  
Predictive Value ◽  
Fetal Growth Restriction ◽  
Protein A ◽  
Outcome Data ◽  
Adverse Outcomes ◽  
Growth Restriction ◽  
Low Levels ◽  
Sensitivity Specificity

Background: The aim of our study was to determine the association of low levels of pregnancy associated plasma protein-A (PAPP-A) levels estimated at 11-13+6weeks of gestation with fetal growth restriction (FGR).Methods: A prospective observational study of a total of 203 pregnant women with PAPP-A levels were followed up and the outcome data were collected at childbirth.Results: The incidence of FGR was 7.3%. A significant association was found between low levels of PAPP-A MoM (≤0.49) with FGR (p=0.000) with unadjusted odds ratio of 11.6. At PAPP-A multiples of median (MoM) ≤0.49, FGR had a median (Q1, Q3) of 0.46 (0.42, 1.54) versus 1.87 (0.59, 3.11) which was statistically significant (p=0.05) with moderate strength of prediction [minus 0.58 (95% CI, minus 1.113, minus 0.055), p=0.03]. At the cut-off considered in our study i.e., ≤0.49 MoM, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 73%, 81%, 23%, and 97% respectively with a positive LR of 3.82 and negative LR of 0.32. Karl Pearson’s correlation showed positive correlation (r=0.308, p<0.001) between PAPP-A MoM and birthweight and showed that for every unit increase in PAPP-A MoM, birthweight increased by 0.082 times (approximately 90 gm). We also found an association of low PAPP-A with pre-eclampsia, preterm delivery and increased caesarean delivery births.Conclusions: We conclude that low PAPP-A MoM levels are good reflectors of placental function and adverse outcomes. PAPP-A, a part of the dual marker, may be extrapolated for suspecting FGR. This could guide in instituting appropriate feto-maternal surveillance.

Role of Color Doppler in Fetal Growth Restriction & Its Fetal Outcome: A Prospective Study

2019 ◽  
Vol 10 (8) ◽  
pp. 296
Author(s):  
Tanu Bhati ◽  
Rajni Agarwal ◽  
R.C Purohit ◽  
Subhash Chand Sylonia ◽  
Kalpana Verma ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Color Doppler ◽  
Fetal Outcome ◽  
Growth Restriction ◽  
A Prospective Study

Pregnancy-associated plasma protein A for prediction of fetal growth restriction

2015 ◽  
Vol 130 (2) ◽  
pp. 200-200 ◽  
Author(s):  
Tsz-kin Lo ◽  
Kelvin Yuen-kwong Chan ◽  
Sario Sau-yuk Chan ◽  
Anita Sik-yau Kan ◽  
Amelia Pui-wah Hui ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Plasma Protein ◽  
Fetal Growth Restriction ◽  
Protein A ◽  
Growth Restriction
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