Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis

2019 ◽  
Vol 299 (5) ◽  
pp. 1295-1303 ◽  
Author(s):  
Qing Xu ◽  
Qinglian Xie
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Prenatal Exposure ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Long Term Effects ◽  
Randomized Controlled ◽  
Follow Up Studies

Safety and Effectiveness of Long-Term Exercise Interventions in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2020 ◽  
Vol 50 (6) ◽  
pp. 1095-1106 ◽  
Author(s):  
Antonio García-Hermoso ◽  
Robinson Ramirez-Vélez ◽  
Mikel L. Sáez de Asteasu ◽  
Nicolás Martínez-Velilla ◽  
Fabricio Zambom-Ferraresi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomized Controlled

scholarly journals Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs

2018 ◽  
Vol 9 (5) ◽  
pp. 1811-1829 ◽  
Author(s):  
Wenneke van Weelden ◽  
Vincent Wekker ◽  
Leon de Wit ◽  
Jacqueline Limpens ◽  
Hilkka Ijäs ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Antidiabetic Drugs ◽  
Long Term Effects ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic ◽  
Follow Up Studies

Long-Term Lithium Therapy for Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials

2004 ◽  
Vol 161 (2) ◽  
pp. 217-222 ◽  
Author(s):  
John R. Geddes ◽  
Sally Burgess ◽  
Keith Hawton ◽  
Kay Jamison ◽  
Guy M. Goodwin
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Lithium Therapy ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Long-term effects of cemented and cementless fixations of total knee arthroplasty: a meta-analysis and systematic review of randomized controlled trials

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Cheng Chen ◽  
Yanyan Shi ◽  
Zhanpo Wu ◽  
Zengxin Gao ◽  
Youmin Chen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Randomized Controlled Trials ◽  
Knee Arthroplasty ◽  
Radiolucent Line ◽  
Controlled Trials ◽  
Long Term Effects ◽  
Randomized Controlled ◽  
Total Knee

Abstract Background To determine the long-term effects (a minimum follow-up time 8.8 years) of cemented and cementless fixations used for total knee arthroplasty (TKA). Methods PubMed, EMBASE, Ovid, Cochrane Library, CINAHL, China National Knowledge Infrastructure and China Wangfang database were interrogated for appropriate randomized controlled trials (RCTs) through July 2020. Data were extracted and assessed for accuracy by 2 of the authors acting independently. Any controversial discrepancies were resolved after discussion with a third author. Result Eight RCTs were included with low to moderate bias risks. The cemented fixation of TKA was comparable to cementless fixation in terms of implant survival (relative risk, 1.016; 95% CI 0.978 to 1.056; P = 0.417), Knee Society (KS) knee score (standardized mean difference (SMD), − 0.107; 95% CI − 0.259 to 0.045; P = 0.168), KS function score (SMD − 0.065; 95% CI − 0.238 to 0.109; P = 0.463), KS pain score (SMD − 0.300; 95% CI − 0.641 to 0.042; P = 0.085), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (SMD − 0.117; 95% CI − 0.307 to 0.073; P = 0.227), HSS score (SMD − 0.027; 95% CI − 0.270 to 0.217; P = 0.829), range of motion (SMD 0.061; 95% CI − 0.205 to 0.327; P = 0.652) at ≥ 8.8 years of follow-up. In terms of radiographic outcomes at ≥ 8.8 years of follow-up, the incidence of a radiolucent line in the cementless group was lower than for the cemented group (SMD 3.828; 95% CI 2.228 to 6.576; P < 0.001). However, the maximum total point motion (MTPM) of the cementless group was greater than for the cemented group (SMD − 0.739; 95% CI − 1.474 to − 0.005; P = 0.048). Conclusions Long-term follow-up verified that cementless and cemented fixation have similar prosthesis survival rates, clinical scores and mobility. However, radiography suggested that each technique had an advantage with regard to the radiolucent line and MTPM.

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