Childhood cancer and residential radon exposure - results of a population-based case-control study in Lower Saxony (Germany)

1999 ◽  
Vol 38 (3) ◽  
pp. 211-215 ◽  
Author(s):  
U. Kaletsch ◽  
P. Kaatsch ◽  
R. Meinert ◽  
J. Schüz ◽  
R. Czarwinski ◽  
...  
1996 ◽  
Vol 40 (3) ◽  
pp. 538-538
Author(s):  
R von Kries ◽  
U Göbel ◽  
A Hachmeister ◽  
U Kaletsch ◽  
J Michaelis

BMJ ◽  
1996 ◽  
Vol 313 (7051) ◽  
pp. 199-203 ◽  
Author(s):  
R. von Kries ◽  
U. Gobel ◽  
A. Hachmeister ◽  
U. Kaletsch ◽  
J. Michaelis

2008 ◽  
Vol 94 (3) ◽  
pp. 228-241 ◽  
Author(s):  
Richard E. Thompson ◽  
Donald F. Nelson ◽  
Joel H. Popkin ◽  
Zenaida Popkin

2012 ◽  
Vol 97 (Suppl 1) ◽  
pp. A5.1-A5
Author(s):  
RM Dommett ◽  
TR Redaniel ◽  
MCG Stevens ◽  
W Hamilton ◽  
RM Martin

Author(s):  
Eung Joo Park ◽  
Hokyou Lee ◽  
Hyeon Chang Kim ◽  
Seung Soo Sheen ◽  
Sang Baek Koh ◽  
...  

Residential radon exposure and cigarette smoking are the two most important risk factors for lung cancer. The combined effects thereof were evaluated in a multi-center matched case-control study in South Korea. A total of 1038 participants were included, comprising 519 non-small cell lung cancer cases and 519 age- and sex- matched community-based controls. Residential radon levels were measured for all participants. Multivariate logistic regression was used to calculate odds ratios (OR) for lung cancer according to radon exposure (high ≥ 100 Bq/m3 vs. low < 100 Bq/m3), smoking status, and combinations of the two after adjusting for age, sex, indoor hours, and other housing information. The median age of the participants was 64 years, and 51.3% were women. The adjusted ORs (95% confidence intervals [CIs]) for high radon and cigarette smoking were 1.56 (1.03–2.37) and 2.53 (1.60–3.99), respectively. When stratified according to combinations of radon exposure and smoking status, the adjusted ORs (95% CIs) for lung cancer in high-radon non-smokers, low-radon smokers, and high-radon smokers were 1.40 (0.81–2.43), 2.42 (1.49–3.92), and 4.27 (2.14–8.52), respectively, with reference to low-radon non-smokers. Both residential radon and cigarette smoking were associated with increased odds for lung cancer, and the difference in ORs according to radon exposure was much greater in smokers than in non-smokers.


Epidemiology ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. S108 ◽  
Author(s):  
S Darby ◽  
E Whitley ◽  
P Silcocks ◽  
B Thakrar ◽  
M Green ◽  
...  

2021 ◽  
Vol 30 (159) ◽  
pp. 200230
Author(s):  
Elvin S. Cheng ◽  
Sam Egger ◽  
Suzanne Hughes ◽  
Marianne Weber ◽  
Julia Steinberg ◽  
...  

BackgroundGlobally, radon is the leading risk factor for lung cancer in never-smokers (LCINS). In this study, we systematically reviewed and meta-analysed the evidence of the risk of LCINS associated with residential radon exposure.MethodsMedline and Embase databases were searched using predefined inclusion and exclusion criteria to identify relevant studies published from 1 January 1990 to 5 March 2020 focused on never-smokers. We identified four pooled collaborative studies (incorporating data from 24 case–control studies), one case–control study and one cohort study for systematic review. Meta-analysis was performed on the results of the four pooled studies due to different measures of effect and outcome reported in the cohort study and insufficient information reported for the case–control study. In a post hoc analysis, the corresponding risk for ever-smokers was also examined.ResultsRisk estimates of lung cancer from residential radon exposure were pooled in the meta-analysis for 2341 never-smoker cases, 8967 never-smoker controls, 9937 ever-smoker cases and 12 463 ever-smoker controls. Adjusted excess relative risks (aERRs) per 100 Bq·m−3 of radon level were 0.15 (95% CI 0.06–0.25) for never-smokers and 0.09 (95% CI 0.03–0.16) for ever-smokers, and the difference between them was statistically insignificant (p=0.32). The aERR per 100 Bq·m−3was higher for men (0.46; 95% CI 0.15–0.76) than for women (0.09; 95% CI −0.02–0.20) among never-smokers (p=0.027).ConclusionThis study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers. Among never-smokers in radon-prone areas, men were at higher risk of lung cancer than women.


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