Circadian heart rate variability in Parkinson's disease

2002 ◽  
Vol 249 (11) ◽  
pp. 1535-1540 ◽  
Author(s):  
Ville Pursiainen ◽  
Tarja H. Haapaniemi ◽  
Juha T. Korpelainen ◽  
Heikki V. Huikuri ◽  
Kyösti A. Sotaniemi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability

scholarly journals Heart Rate Variability Analyses in Parkinson’s Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 (8) ◽  
pp. 959
Author(s):  
Konstantin G. Heimrich ◽  
Thomas Lehmann ◽  
Peter Schlattmann ◽  
Tino Prell
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Meta Analysis ◽  
Cardiac Activity ◽  
Heart Rate Variability Analysis ◽  
Short Term ◽  
Variability Analysis ◽  
Parasympathetic Regulation

Recent evidence suggests that the vagus nerve and autonomic dysfunction play an important role in the pathogenesis of Parkinson’s disease. Using heart rate variability analysis, the autonomic modulation of cardiac activity can be investigated. This meta-analysis aims to assess if analysis of heart rate variability may indicate decreased parasympathetic tone in patients with Parkinson’s disease. The MEDLINE, EMBASE and Cochrane Central databases were searched on 31 December 2020. Studies were included if they: (1) were published in English, (2) analyzed idiopathic Parkinson’s disease and healthy adult controls, and (3) reported at least one frequency- or time-domain heart rate variability analysis parameter, which represents parasympathetic regulation. We included 47 studies with 2772 subjects. Random-effects meta-analyses revealed significantly decreased effect sizes in Parkinson patients for the high-frequency spectral component (HFms2) and the short-term measurement of the root mean square of successive normal-to-normal interval differences (RMSSD). However, heterogeneity was high, and there was evidence for publication bias regarding HFms2. There is some evidence that a more advanced disease leads to an impaired parasympathetic regulation. In conclusion, short-term measurement of RMSSD is a reliable parameter to assess parasympathetically impaired cardiac modulation in Parkinson patients. The measurement should be performed with a predefined respiratory rate.

Subthalamic nucleus deep brain stimulation does not alter long-term heart rate variability in Parkinson’s disease

2006 ◽  
Vol 16 (4) ◽  
pp. 286-288 ◽  
Author(s):  
Tuomo Erola ◽  
Tarja Haapaniemi ◽  
Esa Heikkinen ◽  
Heikki Huikuri ◽  
Vilho Myllyä
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Deep Brain

Circadian rhythm of heart-rate variability and autonomic cardiovascular regulation in Parkinson's disease

2010 ◽  
Vol 158 (1-2) ◽  
pp. 133 ◽  
Author(s):  
Toshihide Harada ◽  
Fumiko Ishizaki ◽  
Maki Hamada ◽  
Nobuko Horie ◽  
Yumiko Nitta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Circadian Rhythm ◽  
Cardiovascular Regulation

Circadian rhythm of heart rate variability and cardiovascular autonomic nervous function in Parkinson's disease

2007 ◽  
Vol 135 (1-2) ◽  
pp. 81
Author(s):  
Toshihide Harada ◽  
Fumiko Ishizaki ◽  
Maki Hamada ◽  
Nobuko Horie ◽  
Tohru Yamada ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Circadian Rhythm ◽  
Autonomic Nervous Function ◽  
Autonomic Nervous ◽  
Nervous Function

Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease

2017 ◽  
Vol 32 (4) ◽  
pp. 610-614 ◽  
Author(s):  
Naomi P. Visanji ◽  
Grace S. Bhudhikanok ◽  
Tiago A. Mestre ◽  
Taneera Ghate ◽  
Kaviraj Udupa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Leucine Rich Repeat

scholarly journals Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2019 ◽  
Author(s):  
Valentina Arnao ◽  
Antonio Cinturino ◽  
Sergio Mastrilli ◽  
Carmelo Buttà ◽  
Carlo Maida ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Ambulatory Setting ◽  
Yahr Stage

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia.Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals.Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed.Results 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN significantly correlated with age, LED, levodopa and SCOPA-AUT scores.Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect a circadian overall sympathetic and parasympathetic disarrangement.

scholarly journals Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020 ◽  
Author(s):  
Valentina Arnao ◽  
Antonio Cinturino ◽  
Sergio Mastrilli ◽  
Carmelo Buttà ◽  
Carlo Maida ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Ambulatory Setting ◽  
Healthy Individuals

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls.Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.

scholarly journals Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020 ◽  
Author(s):  
Valentina Arnao ◽  
Antonio Cinturino ◽  
Sergio Mastrilli ◽  
Carmelo Buttà ◽  
Carlo Maida ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Ambulatory Setting ◽  
Healthy Individuals

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls. Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.

Sign in / Sign up

Export Citation Format

Share Document