Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer’s dementia

2011 ◽  
Vol 259 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Mohamed A. Ahmed ◽  
Esam S. Darwish ◽  
Eman M. Khedr ◽  
Yasser M. El serogy ◽  
Anwer M. Ali
Keyword(s):  
Cognitive Function ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Cortical Excitability ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
High Frequencies

Neurochemical profiles of the anterior temporal lobe predict response of repetitive transcranial magnetic stimulation on semantic processing

2021 ◽  
Author(s):  
JeYoung Jung ◽  
Stephen Williams ◽  
Faezeh Sanae Nezhad ◽  
Matthew Lambon Ralph
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Temporal Lobe ◽  
Magnetic Stimulation ◽  
Semantic Processing ◽  
Cortical Excitability ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Semantic Representation ◽  
Cortical Region ◽  
Anterior Temporal Lobe ◽  
Neurochemical Profiles

Abstract The effect of repetitive transcranial magnetic stimulation can vary considerably across individuals, but the reasons for this still remain unclear. Here, we investigated whether the response to continuous theta-burst stimulation (cTBS) – an effective protocol for decreasing cortical excitability – related to individual differences in glutamate and GABA neurotransmission. We applied cTBS over the anterior temporal lobe (ATL), a hub for semantic representation, to explore the relationship between the baseline neurochemical profiles in this region and the response to this stimulation. Our experiments revealed that non-responders (subjects who did not show an inhibitory effect of cTBS on subsequent semantic performance) had higher excitatory-inhibitory balance (glutamate + glutamine/GABA ratio) in the ATL, which led to up-regulated task-induced regional activity as well as increased ATL-connectivity with other semantic regions compared to responders. These results disclose that the baseline neurochemical state of a cortical region can be a significant factor in predicting responses to cTBS.

Cortical excitability changes after high-frequency repetitive transcranial magnetic stimulation for central poststroke pain

Pain ◽  
2013 ◽  
Vol 154 (8) ◽  
pp. 1352-1357 ◽  
Author(s):  
Koichi Hosomi ◽  
Haruhiko Kishima ◽  
Satoru Oshino ◽  
Masayuki Hirata ◽  
Naoki Tani ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Cortical Excitability ◽  
Repetitive Transcranial Magnetic Stimulation
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