Structure–function relationship between Bruch’s membrane opening-minimum rim width and perimetry in open-angle glaucoma subtypes

2019 ◽  
Vol 258 (3) ◽  
pp. 595-605
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Structure Function ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Structure Function Relationship ◽  
Bruch’S Membrane Opening ◽  
Function Relationship

scholarly journals Structure–function Relationship and Vision-related Quality of Life in Glaucoma Secondary to Anterior Uveitis: Comparison with Open Angle Glaucoma

2021 ◽  
Author(s):  
Jin A Choi ◽  
Ji-Young Lee ◽  
Tae Yoon La ◽  
Jin-Ho Kim
Keyword(s):  
Quality Of Life ◽  
Structure Function ◽  
Visual Function ◽  
Open Angle Glaucoma ◽  
Composite Score ◽  
Open Angle ◽  
Structure Function Relationship ◽  
Related Quality ◽  
Function Relationship

Abstract Uveitis is the most common inflammatory ocular disorder and frequently complicated by glaucoma, which is an important cause of irreversible sight loss. Inflammatory nature of the disease and widely fluctuating of intraocular pressure may affect visual function in patients with uveitis complicated by glaucoma. Therefore, we investigated the structure − function relationship and vision-related quality of life (VR-QoL) in 69 patients with uveitic glaucoma (UG), compared with 138 patients with primary open-angle glaucoma (OAG) using 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). In a generalized linear model including age and corresponding structural metrics, the UG eyes had significantly lower mean deviation (MD) of the whole visual field (VF) and superior VF than the OAG eyes (p = 0.012 and 0.040). Patients with UG showed significantly lower composite score and 5 subscales of the VFQ-25, compared with those with OAG (p < 0.05, for all). In the OAG group, the composite score showed strongest associations with the whole binocular integrated VF (β = 1.156, p < 0.001), whereas in the UG group, a significant association was seen only with the inferior VF of the affected eye (β = 0.747, p = 0.005). In conclusion, eyes with UG exhibited a distinctive structure–function relationship and worse VR-QoL that differentiated them from OAG eyes.

Comparison of the structure–function relationship between compass microperimetry and Humphrey field analyser in myopic open-angle glaucoma eyes

2020 ◽  
pp. bjophthalmol-2020-317850
Author(s):  
Joong Won Shin ◽  
Min Kyung Song ◽  
Hun Jae Won ◽  
Younhye Jo ◽  
Michael S Kook
Keyword(s):  
Structure Function ◽  
Open Angle Glaucoma ◽  
General Structure ◽  
Random Order ◽  
Retinal Nerve Fibre Layer ◽  
Open Angle ◽  
Field Analyser ◽  
Structure Function Relationship ◽  
Nerve Fibre Layer ◽  
Function Relationship

Background/aimsTo compare the structure–function relationship between compass microperimetry (CMP; CenterVue, Padova, Italy) and Humphrey field analyser (HFA; Carl Zeiss Meditec, Dublin, California, USA) in open-angle glaucoma (OAG) eyes with myopia.MethodsCircumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field (VF) mean sensitivity (MS) were obtained in 90 OAG subjects using the optical coherence tomography, CMP and HFA in a random order. The global and sectoral structure–function relationships between the cpRNFLT and VFMS were assessed with different VF devices (CMP vs HHA) in OAG eyes with and without myopia.ResultsOverall, the global and regional structure–function relationships between the two devices did not show significant differences except for the superotemporal sector. In the myopic subgroup, the global association between the average cpRNFLT and VFMSCMP was significantly stronger than that between the average cpRNFLT and VFMSHFA (r=0.806 vs. 0.720, p=0.035). The presence of myopia and higher global cpRNFLT were significantly associated with the greater global VFMS differences between the two devices (p<0.05).ConclusionIn general, structure–function relationship is similar between CMP and HFA in OAG eyes. However, the global structure–function relationship is significantly stronger with CMP than with HFA in OAG eyes with myopia.

Lamina cribrosa position and Bruch’s membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma

2018 ◽  
Vol 29 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Gema Rebolleda ◽  
Ane Pérez-Sarriegui ◽  
Laura Díez-Álvarez ◽  
Victoria De Juan ◽  
Francisco J Muñoz-Negrete
Keyword(s):  
Optic Neuropathy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Lamina Cribrosa ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Open Angle ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Bruch’S Membrane Opening

Purpose: To compare the optic nerve head morphology among primary open-angle glaucoma, non-arteritic anterior ischemic optic neuropathy eyes, their fellow healthy eyes and control eyes, using spectral-domain optical coherence tomography with enhanced depth imaging. Methods: Observational cross-sectional study including 88 eyes of 68 patients. In this study, 23 non-arteritic anterior ischemic optic neuropathy eyes, 17 fellow unaffected eyes, 25 primary open-angle glaucoma eyes, and 23 age-matched control eyes were included. Peripapillary retinal nerve fiber layer thickness and optic disk area were evaluated. Bruch’s membrane opening diameter, optic cup depth, anterior lamina cribrosa depth, and prelaminar tissue thickness were assessed. Results: Non-arteritic anterior ischemic optic neuropathy and primary open-angle glaucoma eyes had similar visual field mean deviation and peripapillary retinal nerve fiber layer thickness (P = 0.6 and P = 0.56, respectively). Bruch’s membrane opening diameter was significantly larger in primary open-angle glaucoma eyes than in control eyes (P = 0.02). Lamina cribrosa and disk cup were deeper in eyes with primary open-angle glaucoma than both control and non-arteritic anterior ischemic optic neuropathy eyes (P < 0.001). Prelaminar tissue thickness was significantly thinner in primary open-angle glaucoma eyes than in non-arteritic anterior ischemic optic neuropathy eyes (P < 0.001). Lamina cribrosa was shallower in both non-arteritic anterior ischemic optic neuropathy and unaffected fellow eyes compared to healthy eyes (P < 0.001 and P = 0.04, respectively). No differences were found in the optic disk area. Conclusion: A forward lamina cribrosa placement and not a smaller disk could be involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy. A significantly larger Bruch’s membrane opening diameter was found in primary open-angle glaucoma eyes compared with control eyes. This issue has clinical implications because Bruch’s membrane opening has been considered a stable reference for disk-related measures.

scholarly journals Factors Associated with Increased Neuroretinal Rim Thickness Measured Based on Bruch’s Membrane Opening-Minimum Rim Width after Trabeculectomy

2021 ◽  
Vol 10 (16) ◽  
pp. 3646
Author(s):  
Do-Young Park ◽  
Soon-Cheol Cha
Keyword(s):  
Open Angle Glaucoma ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fiber Layer ◽  
Factors Associated ◽  
Nerve Fiber Layer Thickness ◽  
Neuroretinal Rim ◽  
Before And After ◽  
Bruch’S Membrane Opening ◽  
Sd Oct

Purpose: To investigate the factors associated with an increase in the neuroretinal rim (NRR) thickness measured based on Bruch’s membrane opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary open-angle glaucoma (POAG). Methods: We analyzed the BMO-MRW using spectral-domain optical coherence tomography (SD-OCT) of patients with POAG who underwent a trabeculectomy for uncontrolled intraocular pressure (IOP) despite maximal IOP reduction treatment. The BMO-MRW was measured before and after trabeculectomy in patients with POAG. Demographic and systemic factors, ocular factors, pre- and post-operative IOP, and visual field parameters were collected, together with SD-OCT measurements. A regression analysis was performed to investigate the factors that affected the change in the BMO-MRW after the trabeculectomy. Results: Forty-four eyes of 44 patients were included in the analysis. The IOP significantly decreased from a preoperative 27.0 mmHg to a postoperative 10.5 mmHg. The mean interval between the trabeculectomy and the date of post-operative SD-OCT measurement was 3.3 months. The global and sectoral BMO-MRW significantly increased after trabeculectomy, whereas the peripapillary retinal nerve fiber layer thickness did not show a difference between before and after the trabeculectomy. Younger age and a greater reduction in the IOP after the trabeculectomy were significantly associated with the increase in the BMO-MRW after trabeculectomy. Conclusions: The NRR thickness measured based on the BMO-MRW increased with decreasing IOP after trabeculectomy, and the increase in the BMO-MRW was associated with the young age of the patients and greater reduction in the IOP after trabeculectomy. Biomechanically, these suggest that the NRR comprises cells and substances that sensitively respond to changes in the IOP and age.

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