scholarly journals High-Pass Visual Acuity Loss and Macular Structure-Function Relationship in Patients With Primary Open-Angle Glaucoma

2021 ◽  
Vol 10 (4) ◽  
pp. 26
Author(s):  
Yun Wen ◽  
Zidong Chen ◽  
Chengguo Zuo ◽  
Yangfan Yang ◽  
Jiangang Xu ◽  
...  
2021 ◽  
Author(s):  
Jin A Choi ◽  
Ji-Young Lee ◽  
Tae Yoon La ◽  
Jin-Ho Kim

Abstract Uveitis is the most common inflammatory ocular disorder and frequently complicated by glaucoma, which is an important cause of irreversible sight loss. Inflammatory nature of the disease and widely fluctuating of intraocular pressure may affect visual function in patients with uveitis complicated by glaucoma. Therefore, we investigated the structure − function relationship and vision-related quality of life (VR-QoL) in 69 patients with uveitic glaucoma (UG), compared with 138 patients with primary open-angle glaucoma (OAG) using 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). In a generalized linear model including age and corresponding structural metrics, the UG eyes had significantly lower mean deviation (MD) of the whole visual field (VF) and superior VF than the OAG eyes (p = 0.012 and 0.040). Patients with UG showed significantly lower composite score and 5 subscales of the VFQ-25, compared with those with OAG (p < 0.05, for all). In the OAG group, the composite score showed strongest associations with the whole binocular integrated VF (β = 1.156, p < 0.001), whereas in the UG group, a significant association was seen only with the inferior VF of the affected eye (β = 0.747, p = 0.005). In conclusion, eyes with UG exhibited a distinctive structure–function relationship and worse VR-QoL that differentiated them from OAG eyes.


2020 ◽  
pp. bjophthalmol-2020-317850
Author(s):  
Joong Won Shin ◽  
Min Kyung Song ◽  
Hun Jae Won ◽  
Younhye Jo ◽  
Michael S Kook

Background/aimsTo compare the structure–function relationship between compass microperimetry (CMP; CenterVue, Padova, Italy) and Humphrey field analyser (HFA; Carl Zeiss Meditec, Dublin, California, USA) in open-angle glaucoma (OAG) eyes with myopia.MethodsCircumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field (VF) mean sensitivity (MS) were obtained in 90 OAG subjects using the optical coherence tomography, CMP and HFA in a random order. The global and sectoral structure–function relationships between the cpRNFLT and VFMS were assessed with different VF devices (CMP vs HHA) in OAG eyes with and without myopia.ResultsOverall, the global and regional structure–function relationships between the two devices did not show significant differences except for the superotemporal sector. In the myopic subgroup, the global association between the average cpRNFLT and VFMSCMP was significantly stronger than that between the average cpRNFLT and VFMSHFA (r=0.806 vs. 0.720, p=0.035). The presence of myopia and higher global cpRNFLT were significantly associated with the greater global VFMS differences between the two devices (p<0.05).ConclusionIn general, structure–function relationship is similar between CMP and HFA in OAG eyes. However, the global structure–function relationship is significantly stronger with CMP than with HFA in OAG eyes with myopia.


2020 ◽  
Vol 61 (14) ◽  
pp. 33
Author(s):  
Damon Wong ◽  
Jacqueline Chua ◽  
Emily Lin ◽  
Bingyao Tan ◽  
Xinwen Yao ◽  
...  

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Asma Shams ◽  
Narain Das ◽  
Noman Rashid ◽  
M. Nasir Bhatti ◽  
Beenish Khan ◽  
...  

Purpose:  To compare the efficacy of the microwave pulse diode laser and argon laser trabeculoplasty in primary open angle glaucoma. Study Design:  Quasi experimental study. Place and Duration of Study:  Shaheed Mohtarma Benazir Bhutto Medical College Lyari and Sindh Government Lyari General Hospital, Karachi, from October, 2017 to March, 2018. Material and Methods:  One hundred and sixty patients, between 42 to 61 years with visual acuity of perception of light to 6/36 were enrolled. Patients diagnosed with POAG were included and patients with intraocular pressure of more than 40 mm Hg, previous glaucoma surgery or laser treatment and narrow angle on gonioscopy were excluded. Ophthalmic examination included visual acuity, slit lamp examination, fundus examination and visual field status using Humphrey perimeter. Patients were divided into two groups. Group A received microwave pulse diode laser (810) and Group B received argon laser trabeculoplasty. Average follow up period was 6 months. Success was assessed objectively by measuring intra ocular pressure and subjectively by visual acuity. Results:  The average time-period for each procedure was 15 ± 5 minutes. In Group A, mean IOP at first week, first month, third month and sixth month was 20.79, 16.34, 16.21and 16.09 mm Hg respectively. While in Group B, IOP at first week, first, third and sixth month was 16.52, 15.76, 13.62, and 12.54 mm Hg at (P < 0.001 in both groups). Conclusion:  Both microwave pulse diode laser and argon laser trabeculoplasty are effective in lowering intra ocular pressures in patients with primary open angle glaucoma.


2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Chenming Zhang ◽  
Min Wu ◽  
Jianrong Wang ◽  
Miaomiao Zhang ◽  
Xu Wang ◽  
...  

The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Among them, 30 patients (41 eyes) were treated with trabeculectomy in combination with 5-FU-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with MMC. Preoperative and postoperative intraocular pressures (IOP), cup/disc ratio, visual acuity and postoperative macular OCT, complications, treatment, and number of corneal endothelial cells were measured, recorded, and analyzed. At the end of 2 years of follow-up, IOP of 36 (87.8%) eyes of patients in the 5-FU group and IOP of 28 (80%) eyes of patients in the MMC group were ≤21 mmHg and patients in the 5-FU group had more stable IOP than patients in the MMC group. During the two years of follow-up, the visual acuity of 22 (53.7%) eyes in the 5-FU group remained unchanged or even improved. Trabeculectomy in combination with 5-FU-soaked biological amniotic membranes can be a surgical option for POAG patients.


2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Daiva Paulaviciute-Baikstiene ◽  
Renata Vaiciuliene ◽  
Vytautas Jasinskas ◽  
Ingrida Januleviciene

Purpose. To evaluate thein vivochanges in Schlemm’s canal (SC) and the trabecular meshwork (TM) in patients with primary open-angle glaucoma (POAG) after phacocanaloplasty using anterior segment optical coherence tomography (AS-OCT).Methods. Ten eyes of nine patients with POAG (6 men and 3 women) who underwent phacocanaloplasty. Preoperative and postoperative visual acuity (VA), intraocular pressure (IOP), and use of glaucoma medications were evaluated. The main outcome measures were the area of SC and TM thickness assessed using AS-OCT before and 12 months after surgery.Results. We found statistically significant reduction in IOP (from 26.4 (8.6) mmHg to 12.9 (2.5) (p<0.05) mmHg), increase in VA from 0.7 (0.4) to 0.9 (0.2), and decrease in glaucoma medication from 2.6 (1.2) to 1.1 (1.3) at 12 months postoperatively. There was a significant increase in the SC area (3081.7 (842.8) μm2versus 5098.8 (1190.5) μm2,p<0.001) and a decrease in mean TM thickness (91.2 (18.6) μm versus 81.3 (15.1) μm,p=0.001) after surgery. We found negative correlations between SC area and IOP before surgery (r=-0.67,p=0.03) and also between SC area before and IOP reduction 12 months after the phacocanaloplasty (r=-0.80,p=0.005).Conclusions. Our results showed statistically significant dilation of SC area and reduction of TM thickness after phacocanaloplasty in POAG patients. The degree of SC expansion was related to the IOP decrease.


2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Karla Tratsk

PURPOSE: In ophthalmology many diseases lead to irreversible blindness, something that implies millions of dollars in care because people with these difficulties loose their autonomy, becoming dependent in all their everyday activities. This presentation will focus on clinical cases of the following pathologies treated with Ozone Therapy because all these were already being treated in a conventional way without signs of improvement. They are primary open-angle glaucoma, age-related macular degeneration, diabetic retinopathy, occlusion of the central retinal artery, facial paralysis and herpetic polyneuropathy associated with orbital apex syndrome. CASE PRESENTATION: As an example, a patient, 73 , female, insulin-dependent diabetes for 10 years, with primary open angle glaucoma, diabetic retinopathy with various laser photocoagulations, vitrectomies and intravitreal injections in both eyes (BE). Visual acuity (VA) of 20/200 in right eye (RE) and 20/100 in left eye (LE). Subjected to the facectomy in RE and with cataract in LE. The fundoscopy was stable in BE. The VA went to 20/200 on 1st day of postoperative period and remained stable until 21st day. After integrative treatment with Ozone Therapy the patient got a VA of 20/60-2 in RE and 20/40-2 in LE, restoring vision and improving her quality of life. Furthermore, she stopped to be insulin dependent, only having to take oral medication. CONCLUSION: The result shows that Ozone therapy should be a therapeutic tool to be associated with Ophthalmology because in many cases, including difficult treatment and evolution, it recovers visual acuity and re-establishes ocular physiology, promoting the maintenance of eye health and vision, contributing to the preservation of autonomy in the lives of patients.


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