scholarly journals 18 F-FDG-PET/MRI in patients with Graves’ orbitopathy.

2021 ◽  
Vol 259 (10) ◽  
pp. 3107-3117
Author(s):  
Manuel Weber ◽  
Cornelius Deuschl ◽  
Nikolaos Bechrakis ◽  
Lale Umutlu ◽  
Gerald Antoch ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Diagnostic Value ◽  
Target Volume ◽  
Total Lesion Glycolysis ◽  
Eye Muscle ◽  
Clinical Assessments ◽  
Graves Orbitopathy ◽  
Time Point ◽  
New Onset

Abstract Purpose Currently, therapeutic management of patients with Graves’ orbitopathy (GO) relies on clinical assessments and MRI. However, monitoring of inflammation remains difficult since external inflammatory signs do not necessarily represent the orbital disease activity. Therefore, we aimed to evaluate the diagnostic value of 18F-FDG-PET/MRI to assess the inflammation of GO patients. Methods Enrolled patients with new onset of GO underwent ophthalmological examinations to evaluate the activity (CAS) and severity of GO (NOSPECS), as well as an 18F-FDG-PET/MRI (Siemens Biograph mMR) with dual time point imaging (immediately post-injection and 60 min p.i.). A subset of PET parameters including maximum standardized uptake value (SUVmax), metabolic target volume (MTV), and total lesion glycolysis (TLG) were obtained separately per eye and per extraocular eye muscle (EOM). EOM thickness was measured on the co-registered MRI. Results Of 14 enrolled patients, three showed mild, seven moderate-to-severe, and four sight-threatening GO. Patients with severe GO showed statistically significant higher TLG than patients with mild GO (p = 0.02) and higher MTV than patients with mild (p = 0.03) and moderate (p = 0.04) GO. Correlation between NOSPECS on one hand and MTV and TLG on the other was significant (R2 = 0.49–0.61). Conclusion TLG and MTV derived from FDG-PET appear to be good discriminators for severe vs. mild-to-moderate GO and show a significant correlation with NOSPECS. As expected, PET parameters of individual eye muscles were not correlated with associated eye motility, since fibrosis, and not inflammation, is mainly responsible for restricted motility. In conclusion, 18F-FDG-PET/MRI can be used for assessment of GO inflammation.

scholarly journals Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hye Seong ◽  
Yong Hyu Jeong ◽  
Woon Ji Lee ◽  
Jun Hyoung Kim ◽  
Jung Ho Kim ◽  
...  
Keyword(s):  
Disease Severity ◽  
Fdg Pet ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Standardized Uptake Value ◽  
Total Lesion Glycolysis ◽  
Positron Emission ◽  
Pet Ct ◽  
Systemic Symptoms ◽  
Fdg Pet Ct

AbstractKikuchi-Fujimoto disease (KFD) is usually self-limiting, but prolonged systemic symptoms often result in frequent hospital visits, long admission durations, or missed workdays. We investigated the role of fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing KFD severity. We reviewed the records of 31 adult patients with pathologically confirmed KFD who underwent 18F-FDG PET/CT between November 2007 and April 2018 at a tertiary-care referral hospital. Disease severity was assessed using criteria based on clinical manifestations of advanced KFD. Systemic activated lymph nodes and severity of splenic activation were determined using semi-quantitative and volumetric PET/CT parameters. The median of the mean splenic standardized uptake value (SUVmean) was higher in patients with severe KFD than those with mild KFD (2.38 ± 1.18 vs. 1.79 ± 0.99, p = 0.058). Patients with severe KFD had more systemically activated volume and glycolytic activity than those with mild KFD (total lesion glycolysis: 473.5 ± 504.4 vs. 201.6 ± 363.5, p = 0.024). Multivariate logistic regression showed that myalgia (odds ratio [OR] 0.035; 95% confidence interval [CI] 0.001–0.792; p = 0.035), total lymph node SUVmax (cutoff 9.27; OR 24.734; 95% CI 1.323–462.407; p = 0.032), and spleen SUVmean (cutoff 1.79; OR 37.770; 95% CI 1.769–806.583; p = 0.020) were significantly associated with severe KFD. 18F-FDG PET/CT could be useful in assessing KFD severity.

Diagnostic value of F-18 FDG PET/CT in patients with spondylodiscitis: Is dual time point imaging time worthy?

2016 ◽  
Vol 85 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Burcak Yilmaz Gunes ◽  
Cetin Onsel ◽  
Kerim Sonmezoglu ◽  
Resat Ozaras ◽  
Metin Halac ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Diagnostic Value ◽  
Imaging Time ◽  
Pet Ct ◽  
Dual Time Point ◽  
Fdg Pet Ct ◽  
Time Point

scholarly journals Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models.

2019 ◽  
Vol 5 (suppl) ◽  
pp. 127-127
Author(s):  
QingLian Wen ◽  
ZhangQiang Xiang
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Fdg Pet ◽  
Rabbit Model ◽  
Standardized Uptake Value ◽  
Target Volume ◽  
Ct Images ◽  
Pathological Examination ◽  
Flt Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

127 Background: To determine the optimum conditions for diagnosis of nasopharyngeal carcinoma, we established VX2 rabbit model to delineate gross target volume (GTV) in different imaging methods. Methods:The orthotopic nasopharyngeal carcinoma (NPC) was established in sixteen New Zealand rabbits. After 7-days inoculation, the rabbits were examined by CT scanning and then sacrificed for pathological examination. To achieve the best delineation, different GTVs of CT, MRI, 18F-FDG PET/CT, and 18F-FLT PET/CT images were correlated with pathological GTV (GTVp). Results: We found 45% and 60% of the maximum standardized uptake value (SUVmax) as the optimal SUV threshold for the target volume of NPC in 18F-FDG PET/CT and 18F-FLT PET/CT images, respectively (GTVFDG45% and GTVFLT60%). Moreover, the GTVMRI and GTVCT were significantly higher than the GTVp ( P ≤ 0.05), while the GTVFDG45% and especially GTVFLT60% were similar to the GTVp ( R = 0.892 and R = 0.902, respectively; P ≤ 0.001). Conclusions: Notably, the results suggested that 18F-FLT PET/CT could reflect the tumor boundaries more accurately than 18F-FDG PET/CT, MRI and CT, which makes 18F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC. Keywords: Nasopharyngeal carcinoma; Gross tumor volume; Magnetic resonance imaging, Computed tomography; 18F-FLT PET/CT; 18F-FDG PET/CT

scholarly journals Prediction of Early Response to Immune Checkpoint Inhibition Using FDG-PET/CT in Melanoma Patients

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3830
Author(s):  
Ken Kudura ◽  
Florentia Dimitriou ◽  
Lucas Basler ◽  
Robert Förster ◽  
Daniela Mihic-Probst ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Tumor Volume ◽  
Predictive Biomarkers ◽  
Total Lesion Glycolysis ◽  
Checkpoint Inhibition ◽  
Patient Level ◽  
Pet Ct ◽  
Melanoma Patients ◽  
Fdg Pet Ct ◽  
Time Point

We aimed to investigate, whether 18F-2-fluoro-2-desoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) scans performed at baseline (time point 0; TP 0) and three months after initiation of immunotherapy (time point 1; TP 1) can be used on a metastasis- and patient-level to predict the response to immune-checkpoint inhibition using FDG-PET/CT six months after treatment start (time point 2; TP 2) in metastatic melanoma patients. This single-center retrospective study considered metastatic melanoma patients treated with immune checkpoint inhibition from TP 0 to TP 2. An analysis on a metastasis- and patient-level was carried out. Tumor volume, standardized uptake values SUV (mean, maximum, and peak), metabolic tumor volume MTV and total lesion glycolysis TLG of each included metastasis were recorded at each time point, respectively TP 0, TP 1 and TP 2. Total tumor volume, total metabolic tumor volume and total lesion glycolysis per patient were also calculated at TP 0, TP 1 and TP 2. Treatment response was assessed at metastasis- and patient-level based on FDG-PET/CT scans at TP 2. 612 melanoma metastases in 111 patients were included. The analysis on a metastasis-level showed that metastatic SUVpeak at TP 1 and volume variation between TP 0 and TP 1 were the strongest negative predictive biomarkers for response. However, at TP 0, metastatic SUVmean and SUVpeak indicated a low negative prediction power, whereas initial metastatic volume was not a predictive biomarker. Also, melanoma metastases located in bone structures had a negative influence on the outcome at TP 2, particularly in women. The analysis on a patient-level showed, that total tumor volume, total metastatic tumor volume and total lesion glycolysis of all metastases three months after treatment initiation were strong negative predictive biomarkers for response to immunotherapy six months after initiation. Age and female sex were also found to be negative predictive biomarkers with lower predictive power. Interestingly, total tumor volume at TP 0 and number of metastases at TP 0 as well as the occurrence of early immune-related adverse events between TP 0 and TP 2 did not have any predictive value for early treatment response. FDG-PET/CT performed for treatment response assessment three months after initiation of immune checkpoint inhibition in metastatic melanoma patients can also be used to predict early response to treatment. On a metastasis-level SUV peak and volume variation of metastases are strong outcome predictive biomarkers. On a patient-level total tumor volume and semiquantitative parameters such as total metabolic tumor volume MTV and total lesion glycolysis TLG of all metastases are promising outcome predictive biomarkers. Also, early complete response on a metastasis- and patient-level seems to be predictive for lasting complete response.

scholarly journals Initial and Delayed Metabolic Activity of Palatine Tonsils Measured with the PET/CT-Dedicated Parameters

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 836
Author(s):  
Agata Pietrzak ◽  
Andrzej Marszalek ◽  
Malgorzata Paterska ◽  
Pawel Golusinski ◽  
Julitta Narozna ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Ct Scanning ◽  
Chronic Tonsillitis ◽  
Palatine Tonsils ◽  
Specificity And Sensitivity ◽  
Positron Emission ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Time Point

One of the most critical elements in the palatine tonsils (PT) patients’ management is to distinguish chronic tonsillitis and malignant tumor. The single-time-point (STP) 2-deoxy-2-[18 F]fluoro-D-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) examination offers the most significant sensitivity and specificity in the head and neck (H&N) region evaluation among commonly used methods of imaging. However, introducing dual-time-point (DTP) scanning might improve the specificity and sensitivity of the technique, limited by the 18 F-FDG non-tumor-specific patterns, especially when comparing different metabolic parameters. The study aims to compare several surrogates of the maximal standardized uptake value (SUVmax), obtained in 36 subjects, divided into confirmed by pathologic study PT cancer and tonsillitis in patients who underwent DTP 18 F-FDG PET/CT scanning. In this study, we observed the increased sensitivity and the specificity of the DTP 18 F-FDG PET/CT when compared with the standard PET/CT protocol. It could be concluded that DTP 18 F-FDG PET/CT improves the PT cancer and chronic tonsillitis differential diagnosis.

scholarly journals The role of functional imaging; DWI, ADC and 18F-FDG PET/CT in the evaluation of HCC treatment response after transarterial chemoembolization

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Ahmed S. Abdelrahman ◽  
Amgad S. Abdel-Rahman ◽  
Noha M. Taha
Keyword(s):  
Functional Imaging ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Diagnostic Value ◽  
Liver Imaging ◽  
Positron Emission ◽  
Pet Ct ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct

Abstract Background The transcatheter arterial chemoembolization (TACE) is one of the treatment lines for patients with hepatocellular carcinoma (HCC), this study was conducted to assess the role of functional imaging including the DWI, ADC and 18F-2-fluoro-2-deoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) for detection of residual HCC after TACE as compared to the structural liver imaging reporting and data system (LI-RADS). Results The optimal cut off value of standardized uptake value ratio (SUVmax/liver SUVmean ratio) for detection of residual viable HCC after TACE was 1.09 with 88.9%, 87.5% and 88.6% sensitivity, specificity, and accuracy respectively, a lower diagnostic value was noted in the qualitative visual FDG PET/CT assessment with sensitivity, specificity, and accuracy of 81.5%, 75% and 80% respectively. The sensitivity, specificity, and accuracy of DWI for identification of post-TACE viable HCC were 77.8%, 75%, and 77.1% respectively. The optimal cut off value of ADC for the diagnosis of variable HCC was 1.32 × 10−3 mm2/s with sensitivity, specificity, and accuracy of 81.5%, 75%, and 80% respectively. Conclusions DWI, ADC and FDG PET/CT are effective functional imaging modalities for the evaluation of viable residual HCC post-TACE with comparable findings for the dynamic cross-section imaging.

FDG PET/MR for therapy response assessment in sarcoma.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e21518-e21518
Author(s):  
Stephan Richter ◽  
Bettina Beuthien-Baumann ◽  
Joerg Kotzerke ◽  
Michael Laniado ◽  
Joerg van den Hoff ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Prognostic Significance ◽  
Standardized Uptake Value ◽  
Therapy Response ◽  
Response Assessment ◽  
Diagnostic Value ◽  
Tracer Injection ◽  
Additional Information ◽  
Medicine Physician ◽  
Metabolic Volume

e21518 Background: Magnetic resonance imaging is the preferred modality for local staging of sarcoma. Positron emission tomography (PET) allows for the evaluation of tissue metabolism. Recently, PET and MR can be performed as a combined examination on a single scanner. The aim of this pilot study was to evaluate the agreement of PET and MR regarding therapy response in patients who received PET/MR for sarcoma staging and assess the diagnostic value of PET/MR in contrast to standalone MR. Methods: Thirteen patients with soft tissue sarcoma (7 m, 6 f, mean age 50 y, age range 18-80 y) received FDG PET MR on to occasions to assess therapy response. Average time between the two scans was 47 d (21-98 d). Average time between tracer injection and the beginning of the PET scan was 70 min (58-106 min). 4.5 MBq 18F-FDG /kg body weight were applied before the examination (252-331 MBq 18F-FDG /patient, 289 MBq on average). Image evaluation was performed separately by a radiologist and a nuclear medicine physician, respectively, who were blinded for other imaging procedures or clinical data. On MR images therapy response was determined according to the RECIST criteria. PET data evaluation included the calculation of mean an maximum SUV (=standardized uptake value) and metabolic volume. In this case, an increase or decrease of 30% or more of the base value was considered a progressive disease or positive response, respectively. Agreement of PET and MR regarding response was evaluated using Cohen's kappa. Results: The primary tumor showed increased FDG uptake in all patients. Response assessment based on RECIST and SUVmean differed in six of 13 cases (k=0,25). Assessment based on RECIST and metabolic volume showed slightly better agreement (k=0,35). Assessment based on RECIST and SUVmax differed in x cases (k=0,34). Conclusions: Sarcoma therapy response based on morphologic MR imaging and PET parameters yield differing results in many cases. FDG positive sarcoma may show a decrease of metabolic parameters on PET scans, while they appear largely unchanged on MR scans. Due to additional information about tumor metabolism provided by PET, PET/MR is a promising modality for sarcoma imaging. Further studies are necessary to evaluate the prognostic significance of PET findings in sarcoma patients.

scholarly journals Prognostic Value of Dual-Time-Point 18F-Fluorodeoxyglucose PET/CT in Metastatic Breast Cancer: An Exploratory Study of Quantitative Measures

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 398
Author(s):  
Mohammad Naghavi-Behzad ◽  
Charlotte Bjerg Petersen ◽  
Marianne Vogsen ◽  
Poul-Erik Braad ◽  
Malene Grubbe Hildebrandt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Survival Time ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Standardized Uptake Value ◽  
Metastatic Breast ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Time Point

This study aimed to compare the prognostic value of quantitative measures of [18F]-fluorodeoxyglucose positron emission tomography with integrated computed tomography (FDG-PET/CT) for the response monitoring of patients with metastatic breast cancer (MBC). In this prospective study, 22 patients with biopsy-verified MBC diagnosed between 2011 and 2014 at Odense University Hospital (Denmark) were followed up until 2019. A dual-time-point FDG-PET/CT scan protocol (1 and 3 h) was applied at baseline, when MBC was diagnosed. Baseline characteristics and quantitative measures of maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), corrected SUVmean (cSUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and corrected TLG (cTLG) were collected. Survival time was analyzed using the Kaplan–Meier method and was regressed on MTV, TLG, and cTLG while adjusting for clinicopathological characteristics. Among the 22 patients included (median age: 59.5 years), 21 patients (95%) died within the follow-up period. Median survival time was 29.13 months (95% Confidence interval: 20.4–40 months). Multivariable Cox proportional hazards regression analyses of survival time showed no influence from the SUVmean, cSUVmean, or SUVmax, while increased values of MTV, TLG, and cTLG were significantly associated with slightly higher risk, with hazard ratios ranging between 1.0003 and 1.004 (p = 0.007 to p = 0.026). Changes from 1 to 3 h were insignificant for all PET measures in the regression model. In conclusion, MTV and TLG are potential prognostic markers for overall survival in MBC patients.

Sign in / Sign up

Export Citation Format

Share Document