The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training

2005 ◽  
Vol 94 (4) ◽  
pp. 371-375 ◽  
Author(s):  
Nathan K. LeBrasseur ◽  
Kelly C. Mizer ◽  
Jascha D. Parkington ◽  
Douglas B. Sawyer ◽  
Roger A. Fielding
2001 ◽  
Vol 90 (6) ◽  
pp. 2341-2350 ◽  
Author(s):  
Charles T. Pu ◽  
Meredith T. Johnson ◽  
Daniel E. Forman ◽  
Jeffrey M. Hausdorff ◽  
Ronenn Roubenoff ◽  
...  

Chronic heart failure (CHF) is characterized by a skeletal muscle myopathy not optimally addressed by current treatment paradigms or aerobic exercise. Sixteen older women with CHF were compared with 80 age-matched peers without CHF and randomized to progressive resistance training or control stretching exercises for 10 wk. Women with CHF had significantly lower muscle strength ( P < 0.0001) but comparable aerobic capacity to women without CHF. Exercise training was well tolerated and resulted in no changes in resting cardiac indexes in CHF patients. Strength improved by an average of 43.4 ± 8.8% in resistance trainers vs. −1.7 ± 2.8% in controls ( P = 0.001), muscle endurance by 299 ± 66% vs. 1 ± 3% ( P = 0.001), and 6-min walk distance by 49 ± 14 m (13%) vs. −3 ± 19 m (−3%) ( P = 0.03). Increases in type I fiber area (9.5 ± 16%) and citrate synthase activity (35 ± 21%) in skeletal muscle were independently predictive of improved 6-min walk distance ( r 2 = 0.78; P = 0.0024). High-intensity progressive resistance training improves impaired skeletal muscle characteristics and overall exercise performance in older women with CHF. These gains are largely explained by skeletal muscle and not resting cardiac adaptations.


2019 ◽  
Vol 31 (4) ◽  
pp. 416-424 ◽  
Author(s):  
Simona Bar-Haim ◽  
Ronit Aviram ◽  
Anat Shkedy Rabani ◽  
Akram Amro ◽  
Ibtisam Nammourah ◽  
...  

Purpose:Exercise interventions have been shown to increase motor capacities in adolescents with cerebral palsy; however, how they affect habitual physical activity (HPA) and sedentary behavior is unclear. The main objective was to correlate changes in HPA with changes in mobility capacity following exercise interventions.Methods:A total of 54 participants (aged 12–20 y) with bilateral spastic cerebral palsy at Gross Motor Function Classification System (GMFCS) levels II and III received 4 months of group progressive resistance training or treadmill training. Mobility measurements and HPA (averaged over 96 h) were made before and after interventions.Results:Averaged baseline mobility and HPA measures and improvements in each after both interventions were positively correlated in all participants. Percentage of sedentary/awake time decreased 2%, with significant increases in HPA measures of step count (16%), walk time (14%), and upright time (9%). Mobility measures and HPA changes were quite similar between Gross Motor Function Classification System levels, but improvement in HPA after group progressive resistance training was greater than after treadmill training (12% vs 4%) and correlated with mobility improvement.Conclusions:Mobility capacity improved after these interventions and was clearly associated with improved HPA. The group progressive resistance training intervention seems preferable to improve HPA, perhaps related to greater social interaction and motivation provided by group training.


1999 ◽  
Vol 9 (6) ◽  
pp. 379-384 ◽  
Author(s):  
Eline Lindeman ◽  
Frank Spaans ◽  
Jos Reulen ◽  
Pieter Leffers ◽  
Jan Drukker

2015 ◽  
Vol 23 (5) ◽  
pp. 644-654 ◽  
Author(s):  
Cristiana Libardi Miranda-Furtado ◽  
Fabiene K. Picchi Ramos ◽  
Gislaine Satyko Kogure ◽  
Barbara A. Santana-Lemos ◽  
Rui Alberto Ferriani ◽  
...  

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