No effect of a 30-h period of sleep deprivation on leukocyte trafficking, neutrophil degranulation and saliva IgA responses to exercise

J. S. Costa Ricardo; Louise Cartner; Samuel J. Oliver; Stewart J. Laing; Robert Walters; James L. J. Bilzon; Neil P. Walsh

doi:10.1007/s00421-008-0931-3

No effect of a 30-h period of sleep deprivation on leukocyte trafficking, neutrophil degranulation and saliva IgA responses to exercise

European Journal of Applied Physiology ◽

10.1007/s00421-008-0931-3 ◽

2008 ◽

Vol 105 (3) ◽

pp. 499-504 ◽

Cited By ~ 18

Author(s):

J. S. Costa Ricardo ◽

Louise Cartner ◽

Samuel J. Oliver ◽

Stewart J. Laing ◽

Robert Walters ◽

...

Keyword(s):

Sleep Deprivation ◽

Leukocyte Trafficking ◽

Neutrophil Degranulation

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Influence of Timing of Postexercise Carbohydrate-Protein Ingestion on Selected Immune Indices

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.19.4.366 ◽

2009 ◽

Vol 19 (4) ◽

pp. 366-384 ◽

Cited By ~ 25

Author(s):

Ricardo J.S Costa ◽

Samuel J. Oliver ◽

Stewart J. Laing ◽

Robert Walters ◽

James L.J Bilzon ◽

...

Keyword(s):

Venous Blood ◽

Stress Hormones ◽

Secretory Iga ◽

Strenuous Exercise ◽

Independent Effect ◽

Leukocyte Trafficking ◽

Norepinephrine Concentration ◽

Protein Ingestion ◽

Neutrophil Degranulation ◽

Unstimulated Saliva

The aim of the study was to determine the influence of immediate and 1-hr-delayed carbohydrate (CHO) and protein (PRO) feeding after prolonged exercise on leukocyte trafficking, bacterially stimulated neutrophil degranulation, saliva secretory IgA (S-IgA) responses, and circulating stress hormones. In randomized order, separated by 1 wk, 9 male runners completed 3 feeding interventions after 2 hr of running at 75% VO2max. During control (CON), participants received water (12 ml/kg body mass [BM]) immediately and 1 hr postexercise. During immediate feeding (IF), participants received a CHO-PRO solution equal to 1.2 g CHO/kg BM and 0.4 g PRO/kg BM immediately postexercise and water 1 hr postexercise. During delayed feeding (DF), participants received water immediately postexercise and CHO-PRO solution 1 hr postexercise. Unstimulated saliva and venous blood samples were collected preexercise, immediately postexercise, and every 20 min until 140 min postexercise. No significant interactions were observed for circulating leukocytes and T-lymphocyte subset counts, S-IgA secretion rate, or plasma cortisol, epinephrine, or norepinephrine concentration. Bacterially stimulated neutrophil degranulation decreased during recovery on CON and DF (24% and 31%, respectively, at 140 min; p < .01) but not on IF. Compared with CON, neutrophil degranulation was higher on IF at 100 min postexercise and higher on IF than DF at 80 min and 100 min onward postexercise (p < .05). Ingestion of a CHO-PRO solution immediately after, but not 1 hr after, prolonged strenuous exercise prevented the decrease in neutrophil degranulation but did not alter circulating stress hormone, leukocyte trafficking, or S-IgA responses. Further research should identify the independent effect of different quantities of CHO and PRO ingestion during recovery on neutrophil responses and other aspects of immune function.

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Matrix metalloproteinase-9 (MMP-9) enhances leukocyte trafficking and alveolar capillary leakage in pancreatitis-associated lung injury by basement membrane digestion

Gastroenterology ◽

10.1016/s0016-5085(01)80543-6 ◽

2001 ◽

Vol 120 (5) ◽

pp. A111-A111

Author(s):

T KECK ◽

J BALCOMIV ◽

B ANTONIU ◽

C FERNANDEZDELCASTILLO ◽

A WARSHAW

Keyword(s):

Basement Membrane ◽

Lung Injury ◽

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 9 ◽

Leukocyte Trafficking ◽

Capillary Leakage ◽

Metalloproteinase 9 ◽

Alveolar Capillary

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Caffeine and Placebo Expectation

Journal of Psychophysiology ◽

10.1027/0269-8803.21.2.91 ◽

2007 ◽

Vol 21 (2) ◽

pp. 91-99 ◽

Cited By ~ 8

Author(s):

Yunfeng Sun ◽

Yinling Zhang ◽

Ning He ◽

Xufeng Liu ◽

Danmin Miao

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Sleep Deprivation ◽

Cognitive Performance ◽

Cognitive Functions ◽

Cardiovascular Regulation ◽

Double Blind ◽

Positive Effects ◽

Pressure Tests ◽

Healthy Males

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.

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