Cardio-respiratory, oxidative stress and acute mountain sickness responses to normobaric and hypobaric hypoxia in prematurely born adults

2020 ◽  
Vol 120 (6) ◽  
pp. 1341-1355 ◽  
Author(s):  
Tadej Debevec ◽  
Vincent Pialoux ◽  
Mathias Poussel ◽  
Sarah J. Willis ◽  
Agnès Martin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hypobaric Hypoxia ◽  
Acute Mountain Sickness ◽  
Mountain Sickness

Elevated plasma S100B levels in high altitude hypobaric hypoxia do not correlate with acute mountain sickness

2014 ◽  
Vol 36 (9) ◽  
pp. 779-785 ◽  
Author(s):  
Craig D. Winter ◽  
Timothy R. Whyte ◽  
John Cardinal ◽  
Stephen E. Rose ◽  
Peter K. O’Rourke ◽  
...  
Keyword(s):  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Acute Mountain Sickness ◽  
Elevated Plasma ◽  
Mountain Sickness

Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude

2011 ◽  
Vol 300 (2) ◽  
pp. R428-R436 ◽  
Author(s):  
Charles S. Fulco ◽  
Stephen R. Muza ◽  
Beth A. Beidleman ◽  
Robby Demes ◽  
Janet E. Staab ◽  
...  
Keyword(s):  
Heart Rate ◽  
Exercise Performance ◽  
Hypobaric Hypoxia ◽  
Sham Group ◽  
Acute Mountain Sickness ◽  
Time Trial ◽  
Normobaric Hypoxia ◽  
Performance Decrement ◽  
Mountain Sickness ◽  
End Tidal

There is an expectation that repeated daily exposures to normobaric hypoxia (NH) will induce ventilatory acclimatization and lessen acute mountain sickness (AMS) and the exercise performance decrement during subsequent hypobaric hypoxia (HH) exposure. However, this notion has not been tested objectively. Healthy, unacclimatized sea-level (SL) residents slept for 7.5 h each night for 7 consecutive nights in hypoxia rooms under NH [ n = 14, 24 ± 5 (SD) yr] or “sham” ( n = 9, 25 ± 6 yr) conditions. The ambient percent O2 for the NH group was progressively reduced by 0.3% [150 m equivalent (equiv)] each night from 16.2% (2,200 m equiv) on night 1 to 14.4% (3,100 m equiv) on night 7, while that for the ventilatory- and exercise-matched sham group remained at 20.9%. Beginning at 25 h after sham or NH treatment, all subjects ascended and lived for 5 days at HH (4,300 m). End-tidal Pco2, O2 saturation (SaO2), AMS, and heart rate were measured repeatedly during daytime rest, sleep, or exercise (11.3-km treadmill time trial). From pre- to posttreatment at SL, resting end-tidal Pco2 decreased ( P < 0.01) for the NH (from 39 ± 3 to 35 ± 3 mmHg), but not for the sham (from 39 ± 2 to 38 ± 3 mmHg), group. Throughout HH, only sleep SaO2 was higher (80 ± 1 vs. 76 ± 1%, P < 0.05) and only AMS upon awakening was lower (0.34 ± 0.12 vs. 0.83 ± 0.14, P < 0.02) in the NH than the sham group; no other between-group rest, sleep, or exercise differences were observed at HH. These results indicate that the ventilatory acclimatization induced by NH sleep was primarily expressed during HH sleep. Under HH conditions, the higher sleep SaO2 may have contributed to a lessening of AMS upon awakening but had no impact on AMS or exercise performance for the remainder of each day.

scholarly journals Oxidative stress and erythropoietin response in altitude exposure

2008 ◽  
Vol 31 (6) ◽  
pp. 380 ◽  
Author(s):  
Hsien-Hao Huang ◽  
Chih-Ly Han ◽  
Horng-Chin Yan ◽  
Woei-Yau Kao ◽  
Chu-Dang Tsai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Altitude ◽  
Sea Level ◽  
Ferritin Level ◽  
Acute Mountain Sickness ◽  
Thiobarbituric Acid ◽  
Altitude Exposure ◽  
Delayed Recovery ◽  
Mountain Sickness ◽  
Stress Burden

Purpose: Oxidative stress and erythropoietin (EPO) levels are increased following high altitude exposure. We hypothesized that the altitude-oxidative stress and EPO response would be associated with the presence or absence of acute mountain sickness (AMS) in subjects exposed at high altitude. Methods: The study enrolled 29 healthy volunteers exposed at altitudes without strenuous physical exercise. Oxidative stress was determined by the spectrophotometric measurement of the colour occurring during the reaction of malondialdehyde (MDA) with thiobarbituric acid (TBA) on blood samples. Ferritin and EPO were also measured simultaneously. Results: During a rise in altitude at 2000 and 3000 m, there were no changes in plasma ferritin level in either of the 2 groups with or without AMS. In contrast, EPO increased at an altitude of 3000 m and after returning to sea level (28.2±2.7, 26.9±3.3 vs 12.2±1.4 and 17.1±1.6, P < 0.05, in group without AMS; 29.3±4.5, 22.8±2.7 vs 10.6±1.0 and 16.1±1.5, # P < 0.05, in group with AMS; compared with the baseline level and at the height of 2000 meters). At a height of 3000 m, plasma MDA level was elevated compared with that at the altitude of baseline and 2000 m in both groups of subjects with and without AMS (3.77±0.29 vs 1.14±0.17, and 1.64±0.22, P < 0.001, in subjects with AMS; 3.65±0.39 vs 1.71±0.21, and 1.73±0.21, P < 0.001, in subjects without AMS) . After returning to sea level, subjects without AMS had lower MDA oxidative stress compared with those with AMS (2.58±0.26 vs 3.51±0.24, P = 0.0223). Along with a rise in altitude, the oxidative stress in these both groups was not correlated with the changes in EPO (r2 = 0.0728, P = 0.1096). Conclusion: High altitude-induced oxidative stress, detected by MDA assay, is not different between the two groups of subjects with and without AMS. Upon return to sea level, subjects without AMS had lower MDA oxidative stress burden and higher EPO level than those with AMS. Whether the subjects with altitude illness had delayed recovery from oxidative stress merits further investigation.

Acute Mountain Sickness Symptomology in Normobaric vs Hypobaric Hypoxia

2015 ◽  
Vol 47 ◽  
pp. 604
Author(s):  
Dana M. DiPasquale ◽  
Gary E. Strangman ◽  
N. Stuart Harris ◽  
Stephen R. Muza
Keyword(s):  
Hypobaric Hypoxia ◽  
Acute Mountain Sickness ◽  
Mountain Sickness

scholarly journals Effect Of Heat Acclimation On Incidence Of Acute Mountain Sickness During Exposure To Hypobaric Hypoxia (3,500 M)

2020 ◽  
Vol 52 (7S) ◽  
pp. 192-192
Author(s):  
Roy M. Salgado ◽  
Adam L. Luippold ◽  
Kirsten E. Coffman ◽  
Karleigh E. Bradbury ◽  
Beau R. Yurkevicius ◽  
...  
Keyword(s):  
Hypobaric Hypoxia ◽  
Acute Mountain Sickness ◽  
Heat Acclimation ◽  
Mountain Sickness

scholarly journals Acute Mountain Sickness Symptoms Depend on Normobaric versus Hypobaric Hypoxia

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Dana M. DiPasquale ◽  
Gary E. Strangman ◽  
N. Stuart Harris ◽  
Stephen R. Muza
Keyword(s):  
Hypobaric Hypoxia ◽  
Assessment Tool ◽  
Classification Tree ◽  
Acute Mountain Sickness ◽  
Self Report ◽  
Shortness Of Breath ◽  
Classification Tree Analysis ◽  
Appetite Loss ◽  
Mountain Sickness ◽  
Normobaric Normoxia

Acute mountain sickness (AMS), characterized by headache, nausea, fatigue, and dizziness when unacclimatized individuals rapidly ascend to high altitude, is exacerbated by exercise and can be disabling. Although AMS is observed in both normobaric (NH) and hypobaric hypoxia (HH), recent evidence suggests that NH and HH produce different physiological responses. We evaluated whether AMS symptoms were different in NH and HH during the initial stages of exposure and if the assessment tool mattered. Seventy-two 8 h exposures to normobaric normoxia (NN), NH, or HH were experienced by 36 subjects. The Environmental Symptoms Questionnaire (ESQ) and Lake Louise Self-report (LLS) were administered, resulting in a total of 360 assessments, with each subject answering the questionnaire 5 times during each of their 2 exposure days. Classification tree analysis indicated that symptoms contributing most to AMS were different in NH (namely, feeling sick and shortness of breath) compared to HH (characterized most by feeling faint, appetite loss, light headedness, and dim vision). However, the differences were not detected using the LLS. These results suggest that during the initial hours of exposure (1) AMS in HH may be a qualitatively different experience than in NH and (2) NH and HH may not be interchangeable environments.

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