Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis

Cognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive fatigability is a common and debilitating symptom in multiple sclerosis (MS), there is currently no standard for its quantification. The objective of this study was to validate the Paced Auditory Serial Addition Test (PASAT) discrete and regression-based normative data for quantifying performance and cognitive fatigability in an Ontario-based sample of individuals with MS. Healthy controls and individuals with MS completed the 3″ and 2″ versions of the PASAT. PASAT performance was measured with total correct, dyad, and percent dyad scores. Cognitive fatigability scores were calculated by comparing performance on the first half (or third) of the task to the last half (or third). The results revealed that the 3″ PASAT was sufficient to detect impaired performance and cognitive fatigability in individuals with MS given the increased difficulty of the 2″ version. In addition, using halves or thirds for calculating cognitive fatigability scores were equally effective methods for detecting impairment. Finally, both the discrete and regression-based norms classified a similar proportion of individuals with MS as having impaired performance and cognitive fatigability. These newly validated discrete and regression-based PASAT norms provide a new tool for clinicians to document statistically significant cognitive fatigability in their patients.

Continuous Versus Intermittent Running: Acute Performance Decrement and Training Load

Purpose: To examine the effect of continuous (CON) and intermittent (INT) running training sessions of different durations and intensities on subsequent performance and calculated training load (TL). Methods: Runners (N = 11) performed a 1500-m time trial as a baseline and after completing 4 different running training sessions. The training sessions were performed in a randomized order and were either maximal for 10 minutes (10CON and 10INT) or submaximal for 25 minutes (25CON and 25INT). An acute performance decrement (APD) was calculated as the percentage change in 1500-m time-trial speed measured after training compared with baseline. The pattern of APD response was compared with that for several TL metrics (bTRIMP, eTRIMP, iTRIMP, running training stress score, and session rating of perceived exertion) for the respective training sessions. Results: Average speed (P < .001, ) was different for each of the initial training sessions, which all resulted in a significant APD. This APD was similar when compared across the sessions except for a greater APD found after 10INT versus 25CON (P = .02). In contrast, most TL metrics were different and showed the opposite response to APD, being higher for CON versus INT and lower for 10- versus 25-minute sessions (P < .001, ). Conclusion: An APD was observed consistently after running training sessions, but it was not consistent with most of the calculated TL metrics. The lack of agreement found between APD and TL suggests that current methods for quantifying TL are flawed when used to compare CON and INT running training sessions of different durations and intensities.

Neural fatigue by passive induction

Theories of mental fatigue disagree on whether performance decrement is caused by motivational or functional alterations. We tested the assumption that keeping neural networks active for an extensive period of time entrains consequences at the subjective, objective and neurophysiological level – the defining characteristics of fatigue – when confounds such as motivation, boredom and level of skill are controlled. We reveal that passive visual stimulation affects visual gamma activity and the performance of a subsequent task when carried out in the same portion of visual space. This outcome was influenced by participants’ level of arousal, manipulated through variations in the difficulty of concurrent auditory tasks. Thus, repeated stimulation of neural networks leads to their altered functional performance and this mechanism seems to play a role in the development of mental fatigue.

The Running Performance Decrement in Elite Hurling

Since the COVID-19 restrictions, hurling games have been played in four quarters instead of two halves. This study described the decrement in running performance between quarters in elite hurling. GPS (10 Hz) were used to collect data from 48 players over 20 games during 2018–2020 season. Total distance (TD), high-speed running (HSR), high-metabolic-load distance (HMLD), sprint-distance, and number of sprints (N-sprints) between quarters were assessed. Greater TD was covered in Q1 than Q3 (Cohen’s d = 0.26). HSR and HMLD was greater in Q1 than Q2 (d = 0.45 and d = 0.55, respectively), Q3 (d = 0.34 and d = 44, respectively) and Q4 (d = 0.38 and d = 0.48, respectively). Sprint-distance and N-sprints were similar (p > 0.05) across quarters. All positions experienced a drop-off in at least one quarter (d = 0.43–1.46) in all metrics except midfielders’ TD and full-forwards’ HSR and HMLD. Sprint-distance and N-sprints were similar (p > 0.05) in each quarter for all positions. Following Q1, players were able to maintain their running performance. The current results can aid the timing of substitutions especially in positions where temporal decrements were observed.

Metabolic and Cardiorespiratory Responses of Semiprofessional Football Players in Repeated Ajax Shuttle Tests and Curved Sprint Tests, and Their Relationship with Football Match Play

In this study, the Ajax Shuttle Test (AST) and the Curved Sprint Test (CST) were conducted on semiprofessional football players to evaluate (1) their test performance, (2) the extent of anaerobic glycolysis by measuring blood lactate, (3) performance decrement and onset of fatigue, and (4) the correlation between selected physiological variables and test performance. Thirty-two semiprofessional Polish football players participated in this study. Both AST and CST were conducted on an outdoor football ground and were conducted in two sets; each set had six repetitions. In the case of AST, the total duration for 6 repetitions of the exercise in Sets 1 and 2 were 90.63 ± 3.71 and 91.65 ± 4.24 s, respectively, whereas, in the case of CST, the respective values were 46.8 ± 0.56 and 47.2 ± 0.66 s. Peak blood lactate concentration [La] after Sets 1 and 2 of AST were 14.47 ± 3.77 and 15.00 ± 1.85 mmol/L, and in the case of CST, the values were 8.17 ± 1.32 and 9.78 ± 1.35 mmol/L, respectively. Performance decrement in AST was more than in CST, both after Set 1 (4.32 ± 1.43 and 3.31 ± 0.96 in AST and CST, respectively) and Set 2 (7.95 ± 3.24 and 3.71 ± 1.02 in AST and CST, respectively). Only in a few of the repetitions, pulmonary ventilation (VE) and oxygen uptake (VO2) were found to be significantly correlated with the performance of the volunteers in both AST and CST. Respiratory exchange ratio (RER) was significantly correlated with most of the repetitions of AST, but not with CST. The study concludes that (1) AST shows more dependence on the anaerobic glycolytic system than shorter repetitive sprints (as in CST), (2) there is more performance decrement and fatigue in AST than in CST, and (3) early decrease in performance and fatigue in the semiprofessional football players in AST and CST may be due to the insufficiency of their aerobic energy system.

The Backward Crosstalk Effect Does Not Depend on the Degree of a Preceding Response Conflict

A common observation in dual tasking is a performance decrement in one or both tasks compared with single tasking. Besides, more specific interference occurs depending on certain characteristics of the two tasks. In particular, even Task 1 performance is often improved when responses in both tasks are compatible (e.g., both require left responses) compared to when they are incompatible: the compatibility-based backward crosstalk effect (BCE). Similar to what is observed for conflict tasks, the BCE is sequentially modulated: It is larger following compatible than following incompatible trials. Previous work has attributed this observation to adaptation effects triggered by response conflict arising during incompatible trials. In two experiments, we assessed sequential modulations following trials with different degrees of such a response conflict. In contrast to our expectations, a clear and sizeable sequential modulation was observed even under conditions where no BCE, and thus no empirical sign of an objective response conflict, was present in the previous trial. Therefore, our results show sequential modulations even without prior response conflict, which is not the (sole) trigger of sequential modulations accordingly. We discuss these results with regard to other potential triggers such as the subjective experience of conflict or difficulty, episodic retrieval, and repetitions of response combinations.

Neurophysiological Vigilance Characterisation and Assessment: Laboratory and Realistic Validations Involving Professional Air Traffic Controllers

Vigilance degradation usually causes significant performance decrement. It is also considered the major factor causing the out-of-the-loop phenomenon (OOTL) occurrence. OOTL is strongly related to a high level of automation in operative contexts such as the Air Traffic Management (ATM), and it could lead to a negative impact on the Air Traffic Controllers’ (ATCOs) engagement. As a consequence, being able to monitor the ATCOs’ vigilance would be very important to prevent risky situations. In this context, the present study aimed to characterise and assess the vigilance level by using electroencephalographic (EEG) measures. The first study, involving 13 participants in laboratory settings allowed to find out the neurophysiological features mostly related to vigilance decrements. Those results were also confirmed under realistic ATM settings recruiting 10 professional ATCOs. The results demonstrated that (i) there was a significant performance decrement related to vigilance reduction; (ii) there were no substantial differences between the identified neurophysiological features in controlled and ecological settings, and the EEG-channel configuration defined in laboratory was able to discriminate and classify vigilance changes in ATCOs’ vigilance with high accuracy (up to 84%); (iii) the derived two EEG-channel configuration was able to assess vigilance variations reporting only slight accuracy reduction.