Role of architecture in determining passive electrical properties in gap junction-connected cells

2000 ◽  
Vol 439 (6) ◽  
pp. 789
Author(s):  
E. Andreu ◽  
E. Fernández ◽  
E. Louis ◽  
G. Ortega ◽  
J.V. Sánchez-Andrés
Keyword(s):  
Electrical Properties ◽  
Gap Junction ◽  
Passive Electrical Properties

Role of architecture in determining passive electrical properties in gap junction-connected cells

2000 ◽  
Vol 439 (6) ◽  
pp. 789-797 ◽  
Author(s):  
E. Andreu ◽  
E. Fernández ◽  
E. Louis ◽  
G. Ortega ◽  
J.V. Sánchez-Andrés
Keyword(s):  
Electrical Properties ◽  
Gap Junction ◽  
Passive Electrical Properties

Role of passive electrical properties during action potential restitution in intact heart

1997 ◽  
Vol 273 (3) ◽  
pp. H1205-H1214 ◽  
Author(s):  
K. R. Laurita ◽  
S. D. Girouard ◽  
Y. Rudy ◽  
D. S. Rosenbaum
Keyword(s):  
Electrical Properties ◽  
Action Potential ◽  
Axial Current ◽  
Propagation Model ◽  
Cell Coupling ◽  
Spatial Gradients ◽  
Dispersion Of Repolarization ◽  
Current Loading ◽  
Passive Electrical Properties

Action potential duration (APD) restitution is classically attributed to membrane ionic currents; however, the role of cell-to-cell coupling in restitution is poorly understood. To test the hypothesis that passive electrical properties of multicellular preparations influence restitution, spatial gradients of transmembrane voltage were measured with high spatial (0.83 mm), voltage (1 mV), and temporal (0.5 ms) resolutions using voltage-sensitive dye in Langendorff-perfused guinea pig ventricle. At short premature coupling intervals, APD failed to shorten in cells located near (< 3 mm) the site of pacing corresponding to the site of earliest repolarization, deviating from classical restitution. In contrast, APD shortened exponentially with increasing stimulus prematurity when pacing was remote from the identical recording site. The mechanism responsible for nonexponential restitution was investigated in a one-dimensional propagation model using the dynamic Luo-Rudy formulation of the ventricular cell and was found to be attributable to depolarizing axial current present in regions of steep repolarization gradients. Moreover, axial current loading attenuated spatial gradients of repolarization that were prominent in the absence of cell-to-cell coupling. These data demonstrate that 1) in contrast to restitution in isolated cells, restitution in multicellular tissue is influenced by axial current from neighboring cells, and 2) in normal myocardium, axial current between cells attenuates dispersion of repolarization during premature stimulation of the heart.

On the validity of the two-cells model in the analysis of passive electrical properties of gap-junction connected cells

2001 ◽  
Vol 30 (5) ◽  
pp. 374-377 ◽  
Author(s):  
E. Andreu ◽  
E. Fernandez ◽  
E. Louis ◽  
G. Ortega ◽  
J.V. Sanchez-Andres
Keyword(s):  
Electrical Properties ◽  
Gap Junction ◽  
Passive Electrical Properties

On the physiological role of internodal potassium channels and the security of conduction in myelinated nerve fibres

1984 ◽  
Vol 220 (1221) ◽  
pp. 415-422 ◽  
Keyword(s):  
Electrical Properties ◽  
Potassium Channels ◽  
Theoretical Analysis ◽  
Physiological Role ◽  
Resting Potential ◽  
Nerve Fibres ◽  
Myelinated Nerve ◽  
Voltage Dependent ◽  
Passive Electrical Properties

A theoretical analysis of the passive electrical properties of normal myelinated nerve suggests that the function of the voltage-dependent potassium channels in the internodal axolemma under the myelin sheath is to permit the generation of an internodal resting potential. Calculation shows that if this internodal potential were not present, the nodal potential would be reduced (by electrotonic short-circuiting) thus impairing the security of conduction. This impairment is particularly pronounced with smaller diameter fibres.

The role of angiotensin in electrophysiological gap junction remodeling in human atrial fibrillation

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
S Dhein ◽  
A Boldt ◽  
J Garbade ◽  
L Polontchouk ◽  
U Wetzel ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gap Junction ◽  
Human Atrial Fibrillation

Electrical properties of planar AlGaN/GaN Schottky diodes: Role of 2DEG and analysis of non-idealities

2017 ◽  
Vol 121 (13) ◽  
pp. 135701 ◽  
Author(s):  
Anna Persano ◽  
Iolanda Pio ◽  
Vittorianna Tasco ◽  
Massimo Cuscunà ◽  
Adriana Passaseo ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Schottky Diodes

Role of Bi chemical pressure on electrical properties of BiFeO3–BaTiO3–based ceramics

2021 ◽  
Vol 114 ◽  
pp. 106562
Author(s):  
Tauseef Ahmed ◽  
Salman Ali Khan ◽  
JiHee Bae ◽  
Muhammad Habib ◽  
Fazli Akram ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Chemical Pressure

scholarly journals Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47311 ◽  
Author(s):  
Nicolas Theodoric ◽  
John F. Bechberger ◽  
Christian C. Naus ◽  
Wun-Chey Sin
Keyword(s):  
Brain Injury ◽  
Gap Junction ◽  
Junction Protein ◽  
Gap Junction Protein
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