Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori–naïve patients

The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day. The assessment involved 1,636 individuals who visited the hospital for general medical checkups. Those negative for Hp antibodies and PG were grouped in group A, Hp-positive/PG-negative subjects were included in group B, and PG-positive subjects in group C. Group A comprised 660 subjects (40.3%), group B 514 (31.4%), and group C 462 (28.2%). Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A. All four patients with gastric adenoma were in group C. Hyperplastic polyps were detected most frequently in group C followed by group B, while there were no cases in group A. By contrast, most fundic gland polyps were found in group A. The detection rate of peptic ulcers was highest in group B, while that of reflux esophagitis was highest in group A. These findings suggest that the “degree of health” of the stomach can be assessed by measuring serum PG and Hp antibodies.

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Effect of Eradication of Helicobacter pylori on Recurrence After Endoscopic Mucosal Resection of Gastric Adenoma and Early Gastric Cancer

Gastroenterology ◽

10.1016/s0016-5085(11)63643-3 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-877

Author(s):

Bae Suheun ◽

Hwoon-Yong Jung ◽

Lee Gin Hyug ◽

Choi Kee Don ◽

Song Ho June ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Endoscopic Mucosal Resection ◽

Gastric Adenoma ◽

Mucosal Resection

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Effect of Helicobacter pylori (HP) infection on early gastric cancer and gastric adenoma

Gastroenterology ◽

10.1016/s0016-5085(00)81132-4 ◽

2000 ◽

Vol 118 (4) ◽

pp. A1318

Author(s):

Eiji Umegaki ◽

Masaya Tanaka ◽

Kaoru Nishimura ◽

Masashi Nanri ◽

Chikao Shimamoto ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Gastric Adenoma

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1044 Effect of Eradication of Helicobacter pylori on Recurrence After Endoscopic Resection of Gastric Adenoma and Early Gastric Cancer

Gastroenterology ◽

10.1016/s0016-5085(12)60686-6 ◽

2012 ◽

Vol 142 (5) ◽

pp. S-183 ◽

Cited By ~ 1

Author(s):

Suh Eun Bae ◽

Hwoon-Yong Jung ◽

Ji-Hoon Jung ◽

Do Hoon Kim ◽

Ji Yong Ahn ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Endoscopic Resection ◽

Gastric Adenoma

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Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori

Scientific Reports ◽

10.1038/s41598-021-04151-5 ◽

2022 ◽

Vol 12 (1) ◽

Author(s):

Bo-Rui Chen ◽

Wei-Ming Li ◽

Tsung-Lin Li ◽

Yi-Lin Chan ◽

Chang-Jer Wu

Keyword(s):

Drug Resistance ◽

Helicobacter Pylori ◽

Cell Model ◽

Host Cells ◽

Total Count ◽

Gastric Adenoma ◽

Antibiotic Failure ◽

H Pylori ◽

Sargassum Hemiphyllum

AbstractHaving infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. H. pylori, however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the H. pylori treatment. We report here that the fucoidan from Sargassum hemiphyllum can significantly reduce the infection of H. pylori without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit H. pylori adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of H. pylori significantly lowering the total count of H. pylori and the level of IL-6 and TNF-α in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the H. pylori infection by reducing both the total count and induced inflammation.

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Helicobacter pylori-negative intestinal-type gastric adenoma successfully treated by endoscopic submucosal dissection: a case report

Endoscopy International Open ◽

10.1055/s-0042-112583 ◽

2016 ◽

Vol 04 (09) ◽

pp. E986-E989 ◽

Cited By ~ 1

Author(s):

Yoshiya Kobayashi ◽

Yoshinori Komazawa ◽

Makoto Nagaoka ◽

Yoshiko Takahashi ◽

Mika Yuki ◽

...

Keyword(s):

Helicobacter Pylori ◽

Case Report ◽

Endoscopic Submucosal Dissection ◽

Intestinal Type ◽

Gastric Adenoma ◽

Submucosal Dissection

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Diagnosis and treatment of the gastric adenoma and Helicobacter pylori-negative atrophic gastritis: clinical case

Dokazatel naya gastroenterologiya ◽

10.17116/dokgastro2020904183 ◽

2020 ◽

Vol 9 (4) ◽

pp. 83

Author(s):

R.O. Kuvaev ◽

O.B. Tkachenko ◽

A.N. Sidorova ◽

E.A. Krainova ◽

S.V. Kashin ◽

...

Keyword(s):

Helicobacter Pylori ◽

Atrophic Gastritis ◽

Clinical Case ◽

Diagnosis And Treatment ◽

Gastric Adenoma

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Fucoidan from Sargassum Hemiphyllum Inhibits Infection and Inflammation of Helicobacter Pylori

10.21203/rs.3.rs-717424/v1 ◽

2021 ◽

Author(s):

Bo-Rui Chen ◽

Wei-Ming Li ◽

Tsung-Lin Li ◽

Yi-Lin Chan ◽

Chang-Jer Wu

Keyword(s):

Drug Resistance ◽

Helicobacter Pylori ◽

Infection Rate ◽

Cell Model ◽

Host Cells ◽

Total Count ◽

Gastric Adenoma ◽

H Pylori ◽

Proper Functions

Abstract When infected by Helicobacter pylori, it often causes gastritis, gastric ulcer, or gastric cancer. Antibiotics are used to treat H. pylori infection, as they inhibit or kill H. pylori often ex-tending to reduce the incidences of gastric adenoma and cancer. However, H. pylori has developed drug resistance to many clinically used antibiotics over the years, thereby providing no warranty of successful treatment whenever H. pylori infection befalls. We report here that fucoidan from Sargassumhemiphyllum can effectively reduce infection of H. pylori without development of drug resistance. Fucoidan demonstrated a strong anti-inflammation activity in RAW264.7 cell model. Using AGS cell model, fucoidan decreased H. pylori adhesion to host cells and thus reduced its infection rate, especially in post-treatment where the infection rate was reduced to 40%. Mechanistically, fucoidan intervenes the proper functions of adhesion molecules BabA and AlpA of H. pylori. Moreover, fucoidan is able to significantly lower the total count of H. pylori and the levels of IL-6 and TNF-α in vivo. Added together, these convergent results suggest that fucoidan is an effective agent in a position to protect stomach from H. pylori infection by reducing its total count and induced inflammation.

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