Reducing negative affect with anodal transcranial direct current stimulation increases memory performance in young—but not in elderly—individuals

2019 ◽  
Vol 224 (8) ◽  
pp. 2973-2982 ◽  
Author(s):  
Jessica Peter ◽  
Elisabeth Neumann-Dunayevska ◽  
Franziska Geugelin ◽  
Nadia Ninosu ◽  
Christian Plewnia ◽  
...  
Keyword(s):  
Negative Affect ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Memory Performance ◽  
Elderly Individuals ◽  
Direct Current Stimulation

scholarly journals Bi-Temporal Anodal Transcranial Direct Current Stimulation during Slow-Wave Sleep Boosts Slow-Wave Density but Not Memory Consolidation

2021 ◽  
Vol 11 (4) ◽  
pp. 410
Author(s):  
Simon Ruch ◽  
Kristoffer Fehér ◽  
Stephanie Homan ◽  
Yosuke Morishima ◽  
Sarah Maria Mueller ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Slow Wave ◽  
Direct Current ◽  
Memory Consolidation ◽  
Transcranial Direct Current Stimulation ◽  
Slow Wave Sleep ◽  
Memory Performance ◽  
Direct Current Stimulation ◽  
Sleep Parameters ◽  
Episodic Memories

Slow-wave sleep (SWS) has been shown to promote long-term consolidation of episodic memories in hippocampo–neocortical networks. Previous research has aimed to modulate cortical sleep slow-waves and spindles to facilitate episodic memory consolidation. Here, we instead aimed to modulate hippocampal activity during slow-wave sleep using transcranial direct current stimulation in 18 healthy humans. A pair-associate episodic memory task was used to evaluate sleep-dependent memory consolidation with face–occupation stimuli. Pre- and post-nap retrieval was assessed as a measure of memory performance. Anodal stimulation with 2 mA was applied bilaterally over the lateral temporal cortex, motivated by its particularly extensive connections to the hippocampus. The participants slept in a magnetic resonance (MR)-simulator during the recordings to test the feasibility for a future MR-study. We used a sham-controlled, double-blind, counterbalanced randomized, within-subject crossover design. We show that stimulation vs. sham significantly increased slow-wave density and the temporal coupling of fast spindles and slow-waves. While retention of episodic memories across sleep was not affected across the entire sample of participants, it was impaired in participants with below-average pre-sleep memory performance. Hence, bi-temporal anodal direct current stimulation applied during sleep enhanced sleep parameters that are typically involved in memory consolidation, but it failed to improve memory consolidation and even tended to impair consolidation in poor learners. These findings suggest that artificially enhancing memory-related sleep parameters to improve memory consolidation can actually backfire in those participants who are in most need of memory improvement.

scholarly journals USING TRANSCRANIAL DIRECT CURRENT STIMULATION TO REDUCE CHRONIC PAIN IN ELDERLY INDIVIDUALS

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 240-240
Author(s):  
M. Harvey ◽  
M. Martel ◽  
F. Houde ◽  
I. Daguet ◽  
M. Séguin ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Elderly Individuals ◽  
Direct Current Stimulation

scholarly journals Differential Age Effects of Transcranial Direct Current Stimulation on Associative Memory

2018 ◽  
Vol 74 (7) ◽  
pp. 1163-1173 ◽  
Author(s):  
Ryan C Leach ◽  
Matthew P McCurdy ◽  
Michael C Trumbo ◽  
Laura E Matzen ◽  
Eric D Leshikar
Keyword(s):  
Older Adults ◽  
Associative Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Recognition Performance ◽  
Memory Performance ◽  
Cued Recall ◽  
Younger Adults ◽  
Delayed Effects ◽  
Direct Current Stimulation

Abstract Objectives Older adults experience associative memory deficits relative to younger adults (Old & Naveh-Benjamin, 2008). The aim of this study was to test the effect of transcranial direct current stimulation (tDCS) on face-name associative memory in older and younger adults. Method Experimenters applied active (1.5 mA) or sham (0.1 mA) stimulation with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) during a face-name encoding task, and measured both cued recall and recognition performance. Participants completed memory tests immediately after stimulation and after a 24-h delay to examine both immediate and delayed stimulation effects on memory. Results Results showed improved face-name associative memory performance for both recall and recognition measures, but only for younger adults, whereas there was no difference between active and sham stimulation for older adults. For younger adults, stimulation-induced memory improvements persisted after a 24-h delay, suggesting delayed effects of tDCS after a consolidation period. Discussion Although effective in younger adults, these results suggest that older adults may be resistant to this intervention, at least under the stimulation parameters used in the current study. This finding is inconsistent with a commonly seen trend, where tDCS effects on cognition are larger in older than younger adults.

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