Screening for non-alcoholic fatty liver disease in children and adolescents with type 1 diabetes mellitus: a cross-sectional analysis

Objectives: To determine the prevalence of diabetes mellitus and pre-diabetes among patients with NAFLD having BMI ≥ 25 kg/m2and compare it with the control group with non-fatty liver with same BMI. Study Design: Prospective, Analytical and Cross-sectional study. Setting: Department of Medicine, Civil Hospital Karachi. Period: January 2015 to October 2016. Material & Methods: The study was conducted among two groups of patients, one with non-alcoholic fatty liver disease (NAFLD), having BMI of ≥25kg/m2and they were compared with a control group having BMI≥25kg/m2 but without fatty liver on ultrasound. Result: Out of 201 NAFLD participants, 82.08% had pre-diabetes and diabetes mellitus, while 82.51% of participants from non-NAFLD (n=101) had pre-diabetes or diabetes mellitus. Insulin resistance was more common among non-NAFLD group than NAFLD group. Most of the metabolic parameter analysed in the study among two groups having slight difference, and they were statistically significant. Conclusion: Pre-diabetes and diabetes mellitus is a frequently reported problem among NAFLD and overweight/obese patients. Insulin resistance was found to be a significant predictor of diabetes mellitus.

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Associations of chronic diarrhoea with non-alcoholic fatty liver disease and obesity-related disorders among US adults

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2019-000322 ◽

2019 ◽

Vol 6 (1) ◽

pp. e000322

Author(s):

Andrea Shin ◽

Huiping Xu ◽

Thomas F Imperiale

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Multinomial Logistic Regression ◽

Chronic Diarrhoea ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Normal Bowel ◽

Sectional Analysis ◽

Alcoholic Fatty Liver Disease

Mechanisms explaining observed associations between diarrhoea and obesity or increased body mass index (BMI) are unclear.ObjectiveTo assess associations of bowel patterns with BMI, metabolic syndrome (MS), non-alcoholic fatty liver disease (NAFLD) and other obesity-related disorders.DesignWe performed a cross-sectional analysis of data from adults who completed bowel health questions for the 2005 to 2010 cycles of the National Health and Nutrition Examination Surveys. Relationships were examined using multinomial logistic regression. Confounding effects of demographics, smoking, alcohol and BMI were examined by sequential modelling.ResultsAmong 13 413 adults, weighted prevalence rates of constipation and diarrhoea were 8.9% and 6.6%, respectively. Mean BMI was associated with bowel patterns (p<0.001), and was higher with diarrhoea (30.3 kg/m2) versus normal bowel patterns (28.6 kg/m2) and with diarrhoea versus constipation (27.8 kg/m2). NAFLD was more prevalent (ORs, 95% CI) in diarrhoea versus normal bowel patterns (OR=1.34, 95% CI 1.01 to 1.78) or constipation (OR=1.45, 95% CI 1.03, 2.03) in adjusted analyses. The higher prevalence of MS in diarrhoea versus constipation (OR=1.27, 95% CI 0.97 to 1.67) was not independent of BMI.ConclusionsThese findings suggest an association between diarrhoea and NAFLD that is independent of BMI.

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