Limb hypotrophy in a child with history of umbilical cord knots. Nerve ultrasound findings

2018 ◽  
Vol 178 (1) ◽  
pp. 111-112
Author(s):  
Daniele Coraci ◽  
Silvia Giovannini ◽  
Claudia Loreti ◽  
Carmen Erra ◽  
Luca Padua
Author(s):  
Elia Shazniza Shaaya ◽  
Siti Atiqah Abdul Halim ◽  
Ka Wen Leong ◽  
Kevin Boon Ping Ku ◽  
Pei Shan Lim ◽  
...  

Background:Candida chorioamnionitis is rarely encountered, even though vulvovaginal candidiasis incidence is about 15%. Interestingly, it has characteristic gross and histological findings on the umbilical cord that are not to be missed. Case Report: We report two cases of Candida chorioamnionitis with presence of multiple yellowish and red spots of the surface of the umbilical cord. Microscopically, these consist of microabscesses with evidence of fungal yeasts and pseudohyphae. The yeasts and pseudohyphae were highlighted by periodic acid– Schiff and Grocott methenamine silver histochemical stains. Both cases were associated with a history of gestational diabetes mellitus. Discussion: Peripheral funisitis is a characteristic feature of Candida chorioamnionitis. It is associated with high risk of adverse perinatal and neonatal outcomes, such as preterm delivery, stillbirth and neonatal death. We recommend careful examination of the umbilical cord of mothers with gestational diabetes mellitus.


2015 ◽  
Vol 126 (1) ◽  
pp. e24
Author(s):  
L. Padua ◽  
M. Lucchetta ◽  
G. Granata ◽  
M. Luigetti ◽  
M. Campagnolo ◽  
...  

2018 ◽  
Vol 129 (11) ◽  
pp. 2259-2267 ◽  
Author(s):  
Giampietro Zanette ◽  
Gian Maria Fabrizi ◽  
Federica Taioli ◽  
Matteo Francesco Lauriola ◽  
Andrea Badari ◽  
...  

2014 ◽  
Vol 22 (1) ◽  
pp. 193-202 ◽  
Author(s):  
M. Lucchetta ◽  
L. Padua ◽  
G. Granata ◽  
M. Luigetti ◽  
M. Campagnolo ◽  
...  

2020 ◽  
Vol 4 (2) ◽  
pp. 01-03
Author(s):  
Philippe PA

Nuchal cord is the umbilical cord accident least associated with stillbirths. It is a common occurrence; however, the expertise to diagnose multiple and tight loops on ultrasound is minimal, especially in limited-resource settings. We report a 30 year-old gravida 1, who presented at a gestation of 39/40+6/7 with a 2 day history of inability to appreciate foetal movements. An urgent obstetric ultrasound revealed absent foetal cardiac activity, reduced amniotic fluid and normal placenta but the report had no comments on the umbilical cord. She delivered a macerated male infant with a tight cord around the neck thrice. This case report highlights the importance of third trimester sonography screening of umbilical cord abnormalities and the mechanism of intrauterine foetal death associated with umbilical cord accidents.


2020 ◽  
Vol 8 (2) ◽  
pp. 78-82
Author(s):  
Katarzyna Stefańska ◽  
Rut Bryl ◽  
Greg Hutchings ◽  
Jamil A. Shibli ◽  
Marta Dyszkiewicz-Konwińska

AbstractStem cells are now one of the most extensively studied fields in experimental medicine. Although embryonic stem cells (ESCs) have the capability to differentiate into lineages derived from all three primary germ layers, their use remains ethically controversial. Mesenchymal stromal cells’ (MSCs) utilization is not burdened with such concerns. MSCs were primarily characterized as fibroblastic cells from bone marrow stroma, with the ability to adhere to plastic and form clonogenic colonies (CFU-Fs – colony-forming unit-fibroblasts). Subsequent studies led to their isolation from various other adult or perinatal tissues, including the umbilical cord. Although in most cases MSCs are obtained from umbilical cords’ stroma (Wharton’s jelly), it has been demonstrated that both cord’s lining and endothelial layer of umbilical vein possess the cells that fulfill the minimal criteria for MSCs published in 2006 by the International Society for Cellular Therapy. Since the initial discovery, a number of pre-clinical and clinical studies were conducted with the use of MSCs derived from umbilical cords, targeting diseases such as cancer or autoimmune diseases. Moreover, their secretome may be even more beneficial, providing an opportunity to create cell-free therapies.Running title: The history of human umbilical cord stem cells


Author(s):  
Merve Akdeniz Leblebicier ◽  
Fatıma Yaman ◽  
İsmail Saraçoğlu ◽  
Vural Kavuncu ◽  
Meltem İmal Kızılkaya

Objectives: The aim of this study was to investigate whether shoulder ultrasound (US) findings were associated with disease activity and pain level in rheumatoid arthritis (RA) patients. Patients and methods: Between April 2019 and November 2019, a total of 60 shoulders of 30 female patients with RA (mean age: 53.8±12.0 years; range, 30 to 65 years) were included. The patients were questioned about shoulder pain and their Disease Activity Score-28 (DAS28) was estimated. After clinical examination with shoulder impingement tests, both shoulders were evaluated by US. Results: Of 60 shoulders examined by shoulder US, the most common shoulder pathology was supraspinatus tendinopathy (n=33, 55%). The prevalence of subdeltoid bursitis on US was significantly higher in the group with moderate disease activity, compared to the group with low disease activity (p<0.05). There were no significant differences in the physical examination findings of patients with low and moderate disease activity. In terms of US findings, subscapularis tendinopathy, glenohumeral joint and acromioclavicular joint degeneration, and subacromial bursitis were more common in shoulders with a history of pain, compared to non-painful shoulders. Conclusion: Shoulder US may be useful for demonstrating shoulder involvement in patients with RA, independent of the presence of shoulder pain.


2020 ◽  
pp. 86-89
Author(s):  
A.A. Pereyaslov ◽  

Gastroschisis and omphalocele are the most common congenital malformations of the abdominal wall that required surgical correction. Despite of the long history of the gastroschisis’ study, there is no generally accepted theory of the pathogenesis of this malformation. There are numerous theories of the pathogenesis of gastroschisis discussed in the modern literature: disorders of differentiation of embrionic mesenchyme as the result of teratogenic influence on the early stages of the embryonic development; rupture of amniotic membrane at the base of the umbilical cord; vascular disorders during of the embryonic development; disorders of the yolk-sac escape. Each of existing theories has its supporters and opponents. It is no generally accepted theory of the pathogenesis of gastroschisis. Most likely is the rupture of physiological hernia along the umbilical cord in its pars flaccid, with the subsequent elongation of the midgut out of the abdominal cavity with the vascular compression, especially of venous and lymphatic vessels. Narrow mesenteric root and narrow-sized defect may contribute to various complications that jeopardize the ultimate prognosis. Further studies are needed to finalize the pathogenesis of gastroschisis. No conflict of interest was declared by the author. Key words: gastroschisis, pathogenesis, vascular disorders, embryonic disorders.


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