103. Nerve ultrasound findings in neuropathy associated with anti-mag antibodies

2015 ◽  
Vol 126 (1) ◽  
pp. e24
Author(s):  
L. Padua ◽  
M. Lucchetta ◽  
G. Granata ◽  
M. Luigetti ◽  
M. Campagnolo ◽  
...  
2018 ◽  
Vol 129 (11) ◽  
pp. 2259-2267 ◽  
Author(s):  
Giampietro Zanette ◽  
Gian Maria Fabrizi ◽  
Federica Taioli ◽  
Matteo Francesco Lauriola ◽  
Andrea Badari ◽  
...  

2014 ◽  
Vol 22 (1) ◽  
pp. 193-202 ◽  
Author(s):  
M. Lucchetta ◽  
L. Padua ◽  
G. Granata ◽  
M. Luigetti ◽  
M. Campagnolo ◽  
...  

2018 ◽  
Vol 89 (6) ◽  
pp. A2.1-A2
Author(s):  
Luciana Pelosi ◽  
Dominic Ming Yin Tse ◽  
Eoin Mulroy ◽  
Andrew M Chancellor ◽  
Michael R Boland

IntroductionUlnar neuropathy with abnormal non-localising electrophysiology (NL-UN) is often associated with significant disability that is difficult to manage due to the absence of anatomically defining studies. We studied demographic, clinical and electrophysiological characteristics of NL-UN and used ultrasound in order to assist with classification and to examine the utility of ultrasound over and above the conventional electro-diagnostic approach.MethodNL-UNs were identified from 113 consecutive referrals to a single neurophysiologist with suspected ulnar neuropathy. All received systematic electro-diagnostic tests and ulnar nerve ultrasound. NL-UN severity was graded using clinical and electrophysiological scales.ResultsIn 64 of 113 referrals, an ulnar mononeuropathy was confirmed by electrophysiology. Sixteen of these 64 (25%) had NL-UN, predominantly males (14 out of 16 patients) with severe or moderately severe clinical and electrophysiological ratings in 81%. Ultrasound showed focal ulnar neuropathy at the elbow (UNE) in 13 out of 16, and diffuse ulnar nerve abnormality in three, and identified a likely or possible causative mechanism in 11 UNEs.ConclusionA quarter of ulnar neuropathies, as demonstrated by abnormal electrophysiology, were NL-UN, of heterogeneous aetiology; the majority were males with significant disability and axonal loss. Ultrasound had a significant role in localization and classification of NL-UN that facilitated management.


2018 ◽  
Vol 178 (1) ◽  
pp. 111-112
Author(s):  
Daniele Coraci ◽  
Silvia Giovannini ◽  
Claudia Loreti ◽  
Carmen Erra ◽  
Luca Padua

2017 ◽  
Vol 60 (2) ◽  
pp. 207-209 ◽  
Author(s):  
Eoin Mulroy ◽  
Andrew M Chancellor ◽  
Luciana Pelosi

Author(s):  
Vivien TY Yong ◽  
Dean Kilfoyle ◽  
David Hutchinson ◽  
Miriam Rodrigues ◽  
Richard Roxburgh ◽  
...  

2019 ◽  
Vol 90 (e7) ◽  
pp. A39.2-A39
Author(s):  
Luciana Pelosi ◽  
Lance Blumhardt ◽  
Vivien Yong

IntroductionThe classification and management of diabetic ulnar mono-neuropathy with non-localizing electrophysiology (NL-UN) is challenging, as this could be due to a focal axonal lesion at the elbow that may require surgery or, be part of the mono-neuritis multiplex spectrum of diabetic neuropathy. The distinction cannot be made by clinical examination and electrophysiology.We investigated the value of nerve ultrasound in this situation.MethodsWe analysed ulnar nerve ultrasound in 9 consecutive diabetic patients (5 males, mean age 65.4 years) with 12 NL-UN affected nerves. The ulnar neuropathy was clinically and electrophysiologically severe in 9 nerves and moderate in 3.ResultsUltrasound showed diffuse ulnar nerve abnormality in 9 nerves (75%) and focal nerve abnormalities at the elbow in 3 (25%)ConclusionsThe majority of NL-UNs in this small sample of patients with diabetes were not due to focal lesions at the elbow. This is in contrast with the nerve ultrasound findings in non-diabetic patients with NL-UN, which almost invariably show a focal lesion at the elbow (Pelosi et al, 2018), and confirms that the pathophysiology of ulnar mono-neuropathy is different and more complex in diabetes.Ultrasound appears to be a useful tool to classify NL-UN in the patient with diabetes and larger studies are indicated.ReferencesPelosi, et al. Ulnar neuropathy with abnormal non-localizing electrophysiology: Clinical, electrophysiological and ultrasound findings. Clin Neurophysiol 2018, 129:2155–2161.


2018 ◽  
Vol 89 (6) ◽  
pp. A32.3-A33
Author(s):  
Luciana Pelosi ◽  
Eoin Mulroy

IntroductionThis is a retrospective review of 135 consecutive patients (M:F=71:64, mean age 52.6 years; 141 arms) referred to our institution with ulnar neuropathy over a two year period. We analysed electrodiagnostic and ultrasound findings in relation to clinical severity.MethodsAll patients underwent electrodiagnostic (AAN) and ultrasound examination of the symptomatic ulnar nerve(s). Clinical severity was graded on a 4 point scale from ‘very mild’ (symptoms only) to ‘severe’ (sensory loss plus marked atrophy of ulnar-innervated hand muscles).ResultsIn ‘very mild’ neuropathies, the number of abnormal electrodiagnostic and ultrasound studies was 2 and 11 respectively, out of 54; in ‘mild’ neuropathies 19 and 25 out of 40; in ‘moderate’, 23 and 24 out of 24; and in ‘severe’, 23 and 23 out of 23. In 25 arms, (18 of which were clinically ‘severe’ or ‘moderate’), electrophysiology was abnormal but non-localising. Ultrasound showed abnormally large cross-sectional area at the elbow in 22 and diffuse nerve enlargement in three. Ultrasound identified nerve subluxation in 24 (17%) neuropathies, 58% of which were ‘very mild’, 25% ‘mild’ and 17% ‘moderate’ or ‘severe’.ConclusionIn patients with symptoms but no clinical signs, electrophysiological evidence of ulnar neuropathy was present in 3.7%, whereas abnormal nerve ultrasound, often associated with subluxation, was demonstrated in 20%. Ultrasound increased the diagnostic yield of electrophysiology in the ‘very mild’ and, to a lesser extent, the ‘mild’ neuropathies by a combined 11%, and localised the lesion in all ulnar neuropathies with abnormal but non-localising electrophysiology. Nerve subluxation was disproportionately represented amongst the clinically ‘very mild’ neuropathies with abnormal ultrasound.


2016 ◽  
Vol 127 (3) ◽  
pp. e130
Author(s):  
L. Padua ◽  
C. Pazzaglia ◽  
D. Coraci ◽  
M. Lucchetta ◽  
I. Paolasso ◽  
...  

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