Recombinant human interferon-gamma in patients with chronic granulomatous disease ? European follow up study

1995 ◽  
Vol 154 (4) ◽  
pp. 295-298 ◽  
Author(s):  
R. S. Weening ◽  
G. J. Leitz ◽  
R. A. Seger
Keyword(s):  
Chronic Granulomatous Disease ◽  
Interferon Gamma ◽  
Human Interferon ◽  
Granulomatous Disease ◽  
Follow Up Study ◽  
Recombinant Human Interferon Gamma

Prostatic Abscess in a Patient with Chronic Granulomatous Disease: A Multi-Disciplinary Intervention

2017 ◽  
Vol 84 (4) ◽  
pp. 267-269 ◽  
Author(s):  
Alberto Martini ◽  
Ioannis Katafigiotis ◽  
Sofia Kalantzi ◽  
Ioannis Anastasiou ◽  
Ioannis Adamakis ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Chronic Granulomatous Disease ◽  
Urine Culture ◽  
Underlying Disease ◽  
Multidrug Resistant ◽  
Granulomatous Disease ◽  
Prostatic Abscess ◽  
The Past ◽  
First Case

Introduction Chronic granulomatous disease (CGD) is a rare pathology that increases patients’ susceptibility to infections, given the inability to generate oxygen radicals to fight microorganisms. In the context of CGD, primary prostatic involvement has been described only once in the past, in a pediatric patient. Case Report We report the case of a 35-year old patient with CGD presenting with persistent fever. After hospital admission, blood and urine were sent for culture and antibiotic therapy was initiated. Patient's conditions continued to deteriorate and an aggressive antibiotic therapy was administered to treat the septic scenario. Urine culture grew a multidrug-resistant Escherichia Coli. After patient's condition improved, a CT scan was performed. The depiction showed multiple abscesses within the prostate. A rectal approach was excluded given patient's underlying disease. A TURP was performed and prostatic pathology resolved. Patient was discharged on postoperative day 14. At 6-month follow-up he hasn't experienced major infections. To the best of our knowledge, this is the first case of septic shock originating from a prostatic abscess in an adult patient with CGD. Conclusions Aggressive medical therapy along with TURP resulted curative in our case. A multi-disciplinary approach was mandatory.

LIVER SCANS IN CHRONIC GRANULOMATOUS DISEASE OF CHILDHOOD

PEDIATRICS ◽  
1971 ◽  
Vol 48 (1) ◽  
pp. 41-50
Author(s):  
L. D. Samuels
Keyword(s):  
Chronic Granulomatous Disease ◽  
Granulomatous Disease ◽  
Recurrent Infections ◽  
Oxidase Deficiency ◽  
Liver Morphology

The biochemical defect of oxidase deficiency present in chronic granulomnatous disease of childhood is manifest clinically by recurrent infections, especially focal abscesses. In the liver these may be bacterial abscesses or characteriastic miliary, sterile granulomas. Either of these can be well-visualized and usefully followed with radioisotope liver scans. Follow-up scans of the liver have shown that chronic changes of the disease may severely distort the gross liver morphology. Cases are presented of two surviving teen-age cousins and two young sisters, subsequently deceased, whose third sibling has just presented with the disease.

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