Markers of drug resistance in relapsing colon cancer

2002 ◽  
Vol 128 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Lazaris A. ◽  
Kavantzas N. ◽  
Zorzos H. ◽  
Tsavaris N. ◽  
Davaris P.
Keyword(s):  
Colon Cancer ◽  
Drug Resistance

scholarly journals Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation

2013 ◽  
Vol 43 (4) ◽  
pp. 1111-1116 ◽  
Author(s):  
WARAPORN MALILAS ◽  
SANG SEOK KOH ◽  
SEOKHO KIM ◽  
RATAKORN SRISUTTEE ◽  
IL-RAE CHO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer

2016 ◽  
Vol 291 (33) ◽  
pp. 17405-17416 ◽  
Author(s):  
Yang Zhang ◽  
Yi Zhang ◽  
Liying Geng ◽  
Haowei Yi ◽  
Wei Huo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Kinase ◽  
Dependent Manner ◽  
Colon Cancer Cells ◽  
Pyruvate Dehydrogenase Kinase 4 ◽  
Mouse Xenograft Model

Drug resistance is one of the main causes of colon cancer recurrence. However, our understanding of the underlying mechanisms and availability of therapeutic options remains limited. Here we show that expression of pyruvate dehydrogenase kinase 4 (PDK4) is positively correlated with drug resistance of colon cancer cells and induced by 5-fluorouracil (5-FU) treatment in drug-resistant but not drug-sensitive cells. Knockdown of PDK4 expression sensitizes colon cancer cells to 5-FU or oxaliplatin-induced apoptosis in vitro and increases the effectiveness of 5-FU in the inhibition of tumor growth in a mouse xenograft model in vivo. In addition, we demonstrate for the first time that TGFβ mediates drug resistance by regulating PDK4 expression and that 5-FU induces PDK4 expression in a TGFβ signaling-dependent manner. Mechanistically, knockdown or inhibition of PDK4 significantly increases the inhibitory effect of 5-FU on expression of the anti-apoptotic factors Bcl-2 and survivin. Importantly, studies of patient samples indicate that expression of PDK4 and phosphorylation of Smad2, an indicator of TGFβ pathway activation, show a strong correlation and that both positively associate with chemoresistance in colorectal cancer. These findings indicate that the TGFβ/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy. A major implication of our studies is that inhibition of PDK4 may have considerable therapeutic potential to overcome drug resistance in colorectal cancer patients, which warrants the development of PDK4-specific inhibitors.

scholarly journals Forkhead box O3 promotes colon cancer proliferation and drug resistance by activating MDR1 expression

2019 ◽  
Vol 7 (3) ◽  
pp. e554 ◽  
Author(s):  
Zhuanglei Gao ◽  
Zhaoxia Li ◽  
Yuelin Liu ◽  
Zhonghao Liu
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Proliferation ◽  
Forkhead Box ◽  
Mdr1 Expression

Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring

Talanta ◽  
2021 ◽  
Vol 222 ◽  
pp. 121441
Author(s):  
Fuentes-Vélez Susana ◽  
Fagoonee Sharmila ◽  
Sanginario Alessandro ◽  
Gallo Valentina ◽  
Riganti Chiara ◽  
...  
Keyword(s):  
Cell Culture ◽  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Real Time ◽  
Colon Cancer Cells ◽  
Culture Monitoring

Colon cancer: Cancer stem cells markers, drug resistance and treatment

2014 ◽  
Vol 68 (8) ◽  
pp. 911-916 ◽  
Author(s):  
Zuzana Kozovska ◽  
Veronika Gabrisova ◽  
Lucia Kucerova
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Stem Cells

Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle

2018 ◽  
Vol 121 ◽  
pp. 10-14 ◽  
Author(s):  
Lubna Siddiqui ◽  
Harshita Mishra ◽  
Pawan Kumar Mishra ◽  
Zeenat Iqbal ◽  
Sushama Talegaonkar
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Relapse ◽  
Cancer Drug Resistance

miRNA-29a reverses P-glycoprotein-mediated drug resistance and inhibits proliferation via up-regulation of PTEN in colon cancer cells

2020 ◽  
Vol 880 ◽  
pp. 173138 ◽  
Author(s):  
Xiaoxin Shi ◽  
Amir Valizadeh ◽  
Seyed Mostafa Mir ◽  
Zatollah Asemi ◽  
Ansar Karimian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein
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