GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas

2017 ◽  
Vol 143 (8) ◽  
pp. 1381-1393 ◽  
Author(s):  
Yurie Mikami ◽  
Shinsuke Fujii ◽  
Kengo Nagata ◽  
Hiroko Wada ◽  
Kana Hasegawa ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Tumor Cell Growth ◽  
Oral Squamous Cell Carcinomas ◽  
Keratin 17

scholarly journals Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 541
Author(s):  
Nandhitha Madhusudhan ◽  
Manuela R. Pausan ◽  
Bettina Halwachs ◽  
Marija Durdević ◽  
Markus Windisch ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Squamous Cell Carcinoma ◽  
Microbial Community ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Microbial Community Composition ◽  
Skin Tumors ◽  
Tumor Cell Growth

The skin microbiota plays a prominent role in health and disease; however, its contribution to skin tumorigenesis is not well understood. We comparatively assessed the microbial community compositions from excision specimens of the main human non-melanoma skin cancers, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Keratinocyte skin tumors are characterized by significantly different microbial community compositions, wherein AK and SCC are more similar to each other than to BCC. Notably, in SCC, which represents the advanced tumor entity and frequently develops from AK, overabundance of Staphylococcus aureus, a known skin pathogen, was noted. Moreover, S. aureus overabundance was significantly associated with increased human β-defensin-2 (hBD-2) expression in SCC. By challenging human SCC cell lines with S. aureus, a specific induction of hBD-2 expression and increased tumor cell growth was seen. Increased proliferation was also induced by directly challenging SCC cells with hBD-2. Together, our data indicate that a changed microbial community composition in SCC, specified by S. aureus overabundance, might promote tumor cell growth via modulation of hBD-2 expression.

scholarly journals Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

1995 ◽  
Vol 36 (3) ◽  
pp. 611-621
Author(s):  
A Abe ◽  
N S Radin ◽  
J A Shayman ◽  
L L Wotring ◽  
R E Zipkin ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
Glucosylceramide Synthase

p53 alterations in betel quid- and tobacco-associated oral squamous cell carcinomas from Taiwan

2007 ◽  
Vol 27 (6) ◽  
pp. 243-248 ◽  
Author(s):  
Yong-Kie Wong ◽  
Tsung-Yun Liu ◽  
Kuo-Wei Chang ◽  
Shu-Chun Lin ◽  
Tsurn-Waan Chao ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Betel Quid ◽  
Oral Squamous Cell Carcinomas

scholarly journals PO-073 Outcomes and patterns of failure of oral squamous cell carcinomas treated post-operatively with IMRT

2019 ◽  
Vol 132 ◽  
pp. 38
Author(s):  
R. Waldram ◽  
A. Taylor ◽  
R. Prestwich ◽  
S. Whittam ◽  
L. Murray ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Patterns Of Failure ◽  
Oral Squamous Cell Carcinomas
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